Details of the Drug Combination

General Information of Drug Combination (ID: DCR5BN8)

• Drug Combination Name: Epirubicin + Raloxifene
• Indication: Glioma; Status: Investigative [1]
• Component Drugs:
  Epirubicin (DMPDW6T): Small molecular drug
  Raloxifene (DMDKF3M): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: SF-539
  Zero Interaction Potency (ZIP) Score: 2.17
  Bliss Independence Score: 4.57
  Loewe Additivity Score: 4.93
  LHighest Single Agent (HSA) Score: 5.51

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Epirubicin

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[2]

Epirubicin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[4]

Epirubicin Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[5]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[6]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[6]

Epirubicin Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Metabolism	[7]

Epirubicin Interacts with 30 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[8]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Increases Expression	[8]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[8]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Response To Substance	[9]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Increases Expression	[10]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[11]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[12]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Increases Expression	[13]
Retinoic acid receptor alpha (RARA)	OT192V9V	RARA_HUMAN	Affects Mutagenesis	[14]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Expression	[8]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Increases Phosphorylation	[15]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[15]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[15]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Affects Mutagenesis	[14]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[16]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[11]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[11]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Increases Phosphorylation	[15]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Expression	[16]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases ADR	[17]
MARVEL domain-containing protein 1 (MARVELD1)	OT5CPOJE	MALD1_HUMAN	Increases Response To Substance	[18]
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)	OT9AGAIJ	LHPP_HUMAN	Increases ADR	[17]
Alpha-protein kinase 1 (ALPK1)	OTBW6SGD	ALPK1_HUMAN	Increases ADR	[19]
Baculoviral IAP repeat-containing protein 6 (BIRC6)	OTCQJAB0	BIRC6_HUMAN	Decreases Response To Substance	[20]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Response To Substance	[21]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Affects Response To Substance	[22]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Response To Substance	[23]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Response To Substance	[24]
Little elongation complex subunit 1 (ICE1)	OTOXTBUH	ICE1_HUMAN	Increases ADR	[17]
Microcephalin (MCPH1)	OTYT3TT5	MCPH1_HUMAN	Increases ADR	[19]

Indication(s) of Raloxifene

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Approved	[3]

Raloxifene Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[25]

Raloxifene Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[26]

Raloxifene Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[27]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[28]
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DEL5N6Y	UD110_HUMAN	Metabolism	[29]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult T acute lymphoblastic leukemia	DC5BLYB	MOLT-4	Investigative	[1]
Astrocytoma	DCPKQK2	U251	Investigative	[1]
Astrocytoma	DCNP7SE	SNB-19	Investigative	[1]
Childhood T acute lymphoblastic leukemia	DCFB4XA	CCRF-CEM	Investigative	[1]
Chronic myelogenous leukemia	DC765AH	K-562	Investigative	[1]
Clear cell renal cell carcinoma	DCXYC66	A498	Investigative	[1]
Clear cell renal cell carcinoma	DCFBPQ4	786-0	Investigative	[1]
Clear cell renal cell carcinoma	DCRA6JR	TK-10	Investigative	[1]
Clear cell renal cell carcinoma	DC5JB0J	CAKI-1	Investigative	[1]
Glioma	DCK3QFE	SF-268	Investigative	[1]
Plasma cell myeloma	DCA35T3	RPMI-8226	Investigative	[1]
Breast adenocarcinoma	DCZ3HIC	MDA-MB-468	Investigative	[30]
Carcinoma	DC9WT79	RXF 393	Investigative	[30]
Colon carcinoma	DCJYQ34	KM12	Investigative	[30]
Invasive ductal carcinoma	DCZAIG7	HS 578T	Investigative	[30]
Invasive ductal carcinoma	DC1KGEM	BT-549	Investigative	[30]
Invasive ductal carcinoma	DC3MYDU	T-47D	Investigative	[30]
Adenocarcinoma	DCT5MUT	DU-145	Investigative	[31]
Adenocarcinoma	DCOYBGJ	OVCAR3	Investigative	[31]
Adenocarcinoma	DCTRI17	NCIH23	Investigative	[31]
Adenocarcinoma	DCRN778	HT29	Investigative	[31]
Adenocarcinoma	DCKB5F4	HCT116	Investigative	[31]
Amelanotic melanoma	DC8MML8	MDA-MB-435	Investigative	[31]
Amelanotic melanoma	DCVLP0T	M14	Investigative	[31]
Cutaneous melanoma	DCR0NA6	SK-MEL-28	Investigative	[31]
High grade ovarian serous adenocarcinoma	DCQ2G7Q	OVCAR-5	Investigative	[31]
High grade ovarian serous adenocarcinoma	DC4U5YT	NCI\\/ADR-RES	Investigative	[31]
Lung adenocarcinoma	DCP6HMO	MDA-MB-231	Investigative	[31]
Lung adenocarcinoma	DCQY5WX	EKVX	Investigative	[31]
Lung adenocarcinoma	DCTTKHL	HOP-62	Investigative	[31]
Lung adenocarcinoma	DC9BX5L	NCI-H522	Investigative	[31]
Malignant melanoma	DC7C8D9	UACC62	Investigative	[31]
Melanoma	DCO2Y8M	SK-MEL-2	Investigative	[31]
Melanoma	DCBJJ7J	MALME-3M	Investigative	[31]
Melanoma	DCB7XBE	UACC-257	Investigative	[31]
Non-small cell lung carcinoma	DCX76WP	HOP-92	Investigative	[31]
Ovarian serous cystadenocarcinoma	DCOGO2L	SK-OV-3	Investigative	[31]
Pleural epithelioid mesothelioma	DCIGTYZ	NCI-H226	Investigative	[31]

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