Details of the Drug Combination

General Information of Drug Combination (ID: DCW5U5J)

• Drug Combination Name: Clavulanate + Amoxicillin
• Indication: Infectious disease; Status: Investigative [1]
• Component Drugs:
  Clavulanate (DM2FGRT): Small molecular drug
  Amoxicillin (DMUYNEI): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Clavulanate

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[2]
Bacterial infection	1A00-1C4Z	Approved	[3]
Staphylococcal pneumonia	N.A.	Approved	[2]
Staphylococcus aureus infection	N.A.	Approved	[2]
Streptococcal pneumonia	N.A.	Approved	[2]
Urinary tract infection	GC08	Approved	[2]
Pneumonia due to Klebsiella pneumoniae	CA40.03	Investigative	[2]
Sinusitis	CA0A.Z	Investigative	[2]

Clavulanate Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[6]

Clavulanate Interacts with 37 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
C-C chemokine receptor type 9 (CCR9)	OT5FSOD8	CCR9_HUMAN	Increases ADR	[7]
C-C chemokine receptor type 4 (CCR4)	OT68KZ9B	CCR4_HUMAN	Increases ADR	[7]
HLA class I histocompatibility antigen, A alpha chain (HLA-A)	OTAH14LU	HLAA_HUMAN	Increases ADR	[8]
C-X-C chemokine receptor type 3 (CXCR3)	OTIGS220	CXCR3_HUMAN	Increases ADR	[7]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[5]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Decreases Expression	[9]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[5]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Expression	[5]
Fibroblast growth factor 19 (FGF19)	OT2DVJWY	FGF19_HUMAN	Increases Expression	[5]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases Expression	[5]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases Expression	[9]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[9]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Increases Expression	[9]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Decreases Expression	[5]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Increases Expression	[9]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[9]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Increases Expression	[5]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Increases Expression	[5]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Decreases Expression	[5]
Cytochrome P450 7A1 (CYP7A1)	OT8Z5KLD	CP7A1_HUMAN	Decreases Expression	[5]
Transketolase (TKT)	OTT5KPUB	TKT_HUMAN	Increases Expression	[5]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Decreases Expression	[5]
NADP-dependent malic enzyme (ME1)	OTSVEUQE	MAOX_HUMAN	Increases Expression	[5]
Lanosterol synthase (LSS)	OT9W2SFH	LSS_HUMAN	Decreases Expression	[5]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Increases Expression	[5]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Increases Expression	[5]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Increases Expression	[9]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Decreases Expression	[5]
Mevalonate kinase (MVK)	OTHJCUKT	KIME_HUMAN	Decreases Expression	[5]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Decreases Expression	[9]
Hepatic sodium/bile acid cotransporter (SLC10A1)	OTUJVMCL	NTCP_HUMAN	Decreases Expression	[5]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Increases Expression	[5]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Decreases Expression	[5]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[5]
ATP-binding cassette sub-family G member 5 (ABCG5)	OT1OMY93	ABCG5_HUMAN	Decreases Expression	[5]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Decreases Expression	[5]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[9]

Indication(s) of Amoxicillin

Disease Entry	ICD 11	Status	REF
Acute otitis media	AB00	Approved	[4]
Bacterial infection	1A00-1C4Z	Approved	[1]
Staphylococcus aureus infection	N.A.	Approved	[4]
Streptococcal pneumonia	N.A.	Approved	[4]
Urinary tract infection	GC08	Approved	[4]
Pneumonia due to Klebsiella pneumoniae	CA40.03	Investigative	[4]
Sinusitis	CA0A.Z	Investigative	[4]

Amoxicillin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Bacterial Cell membrane (Bact CM)	TTXT4D5	NOUNIPROTAC	Modulator	[10]

Amoxicillin Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[11]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[12]
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[12]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[13]

Amoxicillin Interacts with 46 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[14]
Beta-lactamase (blaB)	DED0TBR	A0A414M273_9BACE	Metabolism	[15]
Beta-lactamase (blaB)	DEX8KJO	A6NX15_9FIRM	Metabolism	[16]
Beta-lactamase (blaB)	DEAYSTX	C0W968_9FIRM	Metabolism	[17]
Beta-lactamase (blaB)	DERGEVU	C3WC84_FUSMR	Metabolism	[18]
Beta-lactamase (blaB)	DEV0KWQ	Q8KT52_9BACT	Metabolism	[19]
Beta-lactamase (blaB)	DEQMISO	F9Z530_ODOSD	Metabolism	[18]
Beta-lactamase (blaB)	DEHFJ4G	Q8KT51_9BACT	Metabolism	[18]
Beta-lactamase (blaB)	DEHPJRC	Q8KT60_9BACT	Metabolism	[18]
Beta-lactamase (blaB)	DEITMS0	Q9XBM2_ACIFE	Metabolism	[20]
N-acylhomoserine lactone acylase (lacA)	DEIU0XN	A0A0A1VBK6_9BURK	Metabolism	[21]
Beta-lactamase (blaB)	DET9I1W	BLAC_BACUN	Metabolism	[22]
Beta-lactamase (blaB)	DE7IH52	AMPC_CITFR	Metabolism	[19]
Beta-lactamase (blaB)	DENJ2SQ	BLAB_BACFG	Metabolism	[22]
Beta-lactamase (blaB)	DE5HV8P	A0A4Q5I6I2_9BACE	Metabolism	[22]
Beta-lactamase (blaB)	DE47ARF	B5WXV2_9BACT	Metabolism	[23]
Beta-lactamase (blaB)	DEG2PK9	B5WXV3_BACOV	Metabolism	[22]
Beta-lactamase (blaB)	DEWHJ7A	B5WXV7_BACT4	Metabolism	[22]
Beta-lactamase (blaB)	DEU1RXB	BLAC_BACVU	Metabolism	[22]
Beta-lactamase (blaB)	DETDS7E	A0A2S0LB67_9FLAO	Metabolism	[19]
Beta-lactamase (blaB)	DE37FJH	C6JIU1_FUSVA	Metabolism	[18]
Beta-lactamase (blaB)	DEC7JEF	A0A1S1G219_9NEIS	Metabolism	[19]
Beta-lactamase (blaB)	DEP7MN1	Q9X4S7_PREIN	Metabolism	[24]
Beta-lactamase (blaB)	DEAILCM	A0A246EJV2_9BACT	Metabolism	[24]
Beta-lactamase (blaB)	DET4XFN	Q8KT59_9BACT	Metabolism	[19]
Metallo-beta-lactamase (blaM)	DEPCQ12	Q68K11_ALCXX	Metabolism	[25]
Beta-lactamase (blaB)	DEACNTL	Q2F4C6_SHISO	Metabolism	[26]
Beta-lactamase (blaB)	DEE8742	O32372_CAPOC	Metabolism	[27]
Beta-lactamase (blaB)	DEY09SU	C9MN73_9BACT	Metabolism	[19]
Beta-lactamase (blaB)	DEQLVCA	C9LD75_9BACT	Metabolism	[24]
Beta-lactamase (blaB)	DE2IL34	C2M7J0_CAPGI	Metabolism	[27]
Beta-lactamase (blaB)	DE1NJIW	B6VMJ3_PHOAA	Metabolism	[28]
Beta-lactamase (blaB)	DEDIMN9	A0A413GBG0_9BACE	Metabolism	[22]
Beta-lactamase (blaB)	DEJ8X2W	A0A412YFL9_9BACE	Metabolism	[22]
Beta-lactamase (blaB)	DEFEVNH	A0A381DV31_9FLAO	Metabolism	[27]
Beta-lactamase (blaB)	DEAPGXV	A0A347B2J2_9BACT	Metabolism	[19]
Beta-lactamase (blaB)	DE0PDVC	A0A2A3N1K0_CAPSP	Metabolism	[27]
Beta-lactamase (blaB)	DEQL32N	A0A250F962_9FLAO	Metabolism	[27]
Beta-lactamase (blaB)	DE9HF0I	A0A120A1C6_BACSE	Metabolism	[22]
Beta-lactamase (blaB)	DESHI6O	A0A108T9G3_9BACE	Metabolism	[22]
Beta-lactamase (blaB)	DEZS3N4	A0A069QS91_PRELO	Metabolism	[19]
Beta-lactamase (blaB)	DE5NSUX	A0A095XPV0_9FIRM	Metabolism	[19]
New delhi metallo-beta-lactamase NDM-1 (blaNDM)	DEBGCYQ	A0A345N7K5_SALET	Metabolism	[29]
Beta-lactamase (blaB)	DEW193R	BLA1_KLEPN	Metabolism	[25]
Metallo-beta-lactamase (blaM)	DEK9VG2	BLAN1_KLEPN	Metabolism	[25]
Beta-lactamase (blaB)	DEQ1CTE	A0A2T4TNV5_9BACT	Metabolism	[30]

Amoxicillin Interacts with 15 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)	OTVVI3UI	DQB1_HUMAN	Affects Expression	[31]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Affects Expression	[31]
C-C chemokine receptor type 9 (CCR9)	OT5FSOD8	CCR9_HUMAN	Increases ADR	[7]
C-C chemokine receptor type 4 (CCR4)	OT68KZ9B	CCR4_HUMAN	Increases ADR	[7]
HLA class I histocompatibility antigen, A alpha chain (HLA-A)	OTAH14LU	HLAA_HUMAN	Increases ADR	[8]
C-X-C chemokine receptor type 3 (CXCR3)	OTIGS220	CXCR3_HUMAN	Increases ADR	[7]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Increases Expression	[32]
Cytochrome P450 11B2, mitochondrial (CYP11B2)	OTIOLWYN	C11B2_HUMAN	Increases Expression	[32]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Decreases Activity	[33]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Increases Expression	[34]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[34]
Sulfiredoxin-1 (SRXN1)	OTYDBO4L	SRXN1_HUMAN	Increases Expression	[34]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Decreases Expression	[35]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[35]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Increases Expression	[5]

References

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• [35] Systemic drugs inducing non-immediate cutaneous adverse reactions and contact sensitizers evoke similar responses in THP-1 cells. J Appl Toxicol. 2015 Apr;35(4):398-406. doi: 10.1002/jat.3033. Epub 2014 Aug 4.