Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1P6FR)

Drug Name
Arry-162 Drug Info
Synonyms
606143-89-9; Binimetinib; MEK162; MEK-162; ARRY-438162; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; ARRY 162; UNII-181R97MR71; Binimetinib (MEK162, ARRY-162, ARRY-438162); 181R97MR71; MEK162 (ARRY-162, ARRY-438162); 6-(4-bromo-2-fluorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide; Binimetinib [USAN:INN]; MEK 162; ARRY 438162; MEK162(Binimetinib); Binimetinib (JAN/USAN); D0C4LF; NVP-ME
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Cross-matching ID
PubChem CID
10288191
ChEBI ID
CHEBI:145371
CAS Number
CAS 606143-89-9
TTD Drug ID
DM1P6FR
VARIDT Drug ID
DR01336
INTEDE Drug ID
DR0214
ACDINA Drug ID
D00883

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [6]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [7]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [8]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [9]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [10]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [11]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [12]
Oxaliplatin DMQNWRD Colorectal cancer 2B91.Z Approved [13]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [14]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [17]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [18]
Etoposide DMNH3PG Solid tumour/cancer 2A00-2F9Z Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Mycophenolate mofetil DMPQAGE Organ transplant rejection NE84 Approved [22]
Metronidazole DMTIVEN Amoebiasis 1A36 Approved [23]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [24]
Ethanol DMDRQZU Chronic pain MG30 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Bacterial infection 1A00-1C4Z Approved [26]
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [27]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [28]
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [29]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [28]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [28]
Progesterone DMUY35B Premature labour JB00 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [33]
Methotrexate DM2TEOL leukaemia 2A60-2B33 Approved [34]
Folic acid DMEMBJC Folate-deficiency anemia 3A02.Y Approved [35]
Fluorouracil DMUM7HZ Solid tumour/cancer 2A00-2F9Z Approved [36]
Cisplatin DMRHGI9 Solid tumour/cancer 2A00-2F9Z Approved [37]
Progesterone DMUY35B Premature labour JB00 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [38]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting MAPK/ERK kinase kinase (MAP3K)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trametinib DM2JGQ3 Melanoma 2C30 Approved [42]
Bay 86-9766 DMPW5SB Solid tumour/cancer 2A00-2F9Z Phase 3 [43]
Selumetinib DMC7W6R Melanoma 2C30 Phase 3 [44]
MSC1936369B DMH1DYU Colorectal cancer 2B91.Z Phase 2 [45]
RO-5126766 DM3U9BY Non-small cell lung cancer 2C25 Phase 2 [46]
E6201 DMOSL9P Psoriasis vulgaris EA90 Phase 2 [47]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [2]
WX-554 DMRABOS Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
RG7304 DMGFAVQ Solid tumour/cancer 2A00-2F9Z Phase 1 [48]
BI-847325 DMY4B6J Solid tumour/cancer 2A00-2F9Z Phase 1 [49]
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Drug(s) Targeting ERK activator kinase (MEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
HL-085 DMJDVCW Melanoma 2C30 Phase 1/2 [50]
RG7304 DMGFAVQ Solid tumour/cancer 2A00-2F9Z Phase 1 [48]
GDC-0623 DMDY08K Solid tumour/cancer 2A00-2F9Z Phase 1 [51]
BI 3011441 DMFJGUL Solid tumour/cancer 2A00-2F9Z Phase 1 [52]
Pyridinone compound 1 DM2GR5Q N. A. N. A. Patented [53]
Quinazolines and azaquinazoline derivative 1 DME24BI N. A. N. A. Patented [53]
PMID28594589-Compound-TABLE3C2 DMVYG0U N. A. N. A. Patented [53]
Benzoheterocyclic compound 1 DM3K25J N. A. N. A. Patented [53]
Benzoimidazole derivative 1 DMUJFCK N. A. N. A. Patented [53]
PMID28594589-Compound-TABLE3C12 DMPK7IU N. A. N. A. Patented [53]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ERK activator kinase (MEK) TTZCRP3 NOUNIPROTAC Inhibitor [1]
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) Main DME DEYGVN4 UD11_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [5]

References

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35 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
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