Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM62UHC)

• Drug Name: Meropenem Drug Info
• Synonyms: MEPM; MERONEM; Meropen; Merrem; Meropenem anhydrous; Mepem (TN); Meronem (TN); Meropen (TN); Meropenem (INN); Merrem (TN); Neopenem (TN); SM-7338; Meronem; Merrem I.V. (TN); (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate; (2S,3R,4R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid; (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5S,6S)-3-((3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-ylthio)-6-((S)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (6S)-2-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-1beta-methyl-2,3-didehydro-1-carbapenam-3-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Meningococcal meningitis		Approved	[2]
Peritonitis		Approved	[2]
Pneumococcal meningitis		Approved	[2]
Pseudomonas aeruginosa infectious disease		Approved	[2]

• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 441130
  ChEBI ID: CHEBI:43968
  CAS Number: CAS 96036-03-2
  TTD Drug ID: DM62UHC
  VARIDT Drug ID: DR01200
  INTEDE Drug ID: DR2491

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[13]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[14]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[3]
Ticarcillin	DM4ME02	Aspiration pneumonia		Approved	[15]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[16]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[17]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[19]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[20]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[21]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[25]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[25]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[26]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[27]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[28]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[29]

Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[6]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[6]
Doripenem	DM9UCJK	Cholecystitis		Approved	[6]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[7]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[7]
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[30]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[31]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[10]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[32]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[32]
Carbapenem	DMXZU73	N. A.	N. A.	Phase 4	[33]
Ceftazidine	DMPZTRC	N. A.	N. A.	Phase 4	[32]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[11]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[34]

Drug(s) Metabolized By Carbapenemase (cphA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[8]

Drug(s) Metabolized By New delhi metallo-beta-lactamase NDM-1 (blaNDM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[5]

Drug(s) Affected By HLA class II histocompatibility antigen, DO beta chain (HLA-DOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[35]
Trimethoprim	DMM7CHK	Acute otitis media	AB00	Approved	[12]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[37]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[38]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[12]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[12]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
New delhi metallo-beta-lactamase NDM-1 (blaNDM)	DEBGCYQ	A0A345N7K5_SALET	Substrate	[5]
Beta-lactamase (blaB)	DEC3G7M	A0A1S7IV31_ENTAS	Substrate	[6]
Beta-lactamase (blaB)	DENJ2SQ	BLAB_BACFG	Substrate	[7]
Carbapenemase (cphA)	DEB90AL	BLAB_AERHY	Substrate	[8] , [9]
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[10]
Beta-lactamase (blaB)	DECWSA9	AMPC_MORMO	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Gene/Protein Processing	[12]
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB)	OTKADDUB	DOB_HUMAN	Gene/Protein Processing	[12]

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