Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEPWYA)

• Drug Name: THIOCOLCHICOSIDE Drug Info
• Synonyms: Thiocolchicoside; 602-41-5; Coltramyl; UNII-T1X8S697GT; Thiocolchicine 2-glucoside analog; NSC 147755; Musco-ril; T1X8S697GT; 10-Thiocolchicoside; Tiocolchicoside [DCIT]; Colchicoside, 10-thio-; Thiocolchicoside [INN:DCF]; Q-201823; Thiocolchicosidum [INN-Latin]; Tiocolchicosido [INN-Spanish]; C27H33NO10S; Tiocolchicosido; Tiocolchicoside; Muscoril; Thiocolchicosidum; EINECS 210-017-7; BRN 0072205; R. 271; 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine; Miotens; Coltrax; NSC147755; Coltramyl (TN); NCGC00016519-01

Indication

Disease Entry	ICD 11	Status	REF
Muscle spasm	MB47.3	Approved	[1]

• Cross-matching ID:
  PubChem CID: 9915886
  ChEBI ID: CHEBI:94557
  CAS Number: CAS 602-41-5
  TTD Drug ID: DMEPWYA

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[3]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[4]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[2]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[3]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[5]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[6]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[7]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[8]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[9]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Strychnine-binding glycine receptor (GLRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[11]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[12]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	DME8VPC	Discovery agent	N.A.	Investigative	[2]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine	DMXFVD1	Discovery agent	N.A.	Investigative	[2]
3-demethoxy-3-L-fucopyranosylaminothiocolchicine	DM4ERYF	Discovery agent	N.A.	Investigative	[2]
3-demethoxy-3D-glucopyranosylaminothiocolchicine	DMID7TC	Discovery agent	N.A.	Investigative	[2]
3-demethoxy-3-D-mannopyranosylaminothiocolchicine	DMALMGH	Discovery agent	N.A.	Investigative	[2]
GINKGOLIDE A	DMKZJ7T	Discovery agent	N.A.	Investigative	[12]
Ginkgolide J	DMUOMP1	Discovery agent	N.A.	Investigative	[12]
Ginkgolide C	DMVN374	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[13]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[14]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[13]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[13]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[3]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[13]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[13]
Meprobamate	DMHM93Y	Anxiety		Approved	[13]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[15]
Ethchlorvynol	DM53IP1	Insomnia	7A00-7A0Z	Approved	[13]

Drug(s) Targeting Glycine receptor (GlyR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9379	DM3KYO4	Cerebrovascular ischaemia	8B1Z	Phase 1	[16]
UK-240455	DMSCXB7	Nerve injury	ND56.4	Phase 1	[17]
MDL-27531	DMC60S8	Epilepsy	8A60-8A68	Phase 1	[18]
Gavestinel	DM8IL1U	Nerve injury	ND56.4	Discontinued in Phase 2	[19]
GV-196771	DMFN21T	Migraine	8A80	Discontinued in Phase 2	[20]
GW 468816	DMQ92WF	Tobacco dependence	6C4A.2	Discontinued in Phase 2	[21]
M-241247	DMIY51U	Cerebrovascular ischaemia	8B1Z	Terminated	[22]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[12]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	DME8VPC	Discovery agent	N.A.	Investigative	[2]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine	DMXFVD1	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[13]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[23]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[24]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[25]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[26]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[27]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[28]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[23]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[4]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[2]

Drug(s) Targeting GABA(A) receptor beta-2 (GABRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[3]
Ethchlorvynol	DM53IP1	Insomnia	7A00-7A0Z	Approved	[13]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[4]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[2]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[3]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[29]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[6]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[30]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[9]
Ro-15-3505	DM4NW3U	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Inhibitor	[2]
GABA(A) receptor beta-2 (GABRB2)	TTZA1NY	GBRB2_HUMAN	Inhibitor	[2]
GABA(A) receptor gamma-2 (GABRG2)	TT06RH5	GBRG2_HUMAN	Inhibitor	[2]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[2]
Glycine receptor (GlyR)	TTZ8EM9	GLRA1_HUMAN; GLRA2_HUMAN; GLRA3_HUMAN; GLRA4_HUMAN; GLRB_HUMAN	Inhibitor	[2]
Strychnine-binding glycine receptor (GLRA1)	TTF45NW	GLRA1_HUMAN	Inhibitor	[2]

References

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