Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMINM2D)

Drug Name
carvacrol Drug Info
Synonyms
CARVACROL; 5-Isopropyl-2-methylphenol; 499-75-2; Isopropyl-o-cresol; Karvakrol; o-Thymol; Antioxine; 5-Isopropyl-o-cresol; 2-p-Cymenol; 2-Hydroxy-p-cymene; Isothymol; Phenol, 2-methyl-5-(1-methylethyl)-; p-Cymen-2-ol; 2-Methyl-5-isopropylphenol; 3-Isopropyl-6-methylphenol; p-Cymene, 2-hydroxy-; 5-Isopropyl-2-methyl-phenol; 2-Methyl-5-(Propan-2-Yl)Phenol; 2-Methyl-5-(1-methylethyl)phenol; o-Cresol, 5-isopropyl-; 1-Hydroxy-2-methyl-5-isopropylbenzene; 6-Methyl-3-isopropylphenol; Phenol, 5-isopropyl-2-methyl-; Cymene-2-ol, p-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10364
ChEBI ID
CHEBI:3440
CAS Number
CAS 499-75-2
TTD Drug ID
DMINM2D

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Clinical Trial Drug(s)
Approved Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Long transient receptor potential channel 7 (TRPM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-APB DM9AKVR Discovery agent N.A. Investigative [9]
PIP2 DMOZV7N Discovery agent N.A. Investigative [10]
waixenicin A DMB6H35 Discovery agent N.A. Investigative [11]
Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SAR292833 DM63QY0 Pain MG30-MG3Z Phase 2 [12]
2-APB DM9AKVR Discovery agent N.A. Investigative [13]
diphenylboronic anhydride DMRQZTS Discovery agent N.A. Investigative [14]
citral DM53ZGY Discovery agent N.A. Investigative [15]
aspirin-triggered resolvin D1 DMOP941 Discovery agent N.A. Investigative [16]
cinnamaldehyde DMZDUXG Discovery agent N.A. Investigative [17]
diphenyltetrahydrofuran DMK8T61 Discovery agent N.A. Investigative [14]
carveol DMGIZ5U Discovery agent N.A. Investigative [18]
dihydrocarveol DMS4U68 Discovery agent N.A. Investigative [18]
tetrahydrocannabivarin DMDY1MZ Discovery agent N.A. Investigative [19]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [20]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [21]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [22]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Ethacrynic acid DM60QMR Edema MG29 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [27]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [28]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [29]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [38]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [39]
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Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Capsaicin DMGMF6V Back pain ME84.Z Approved [43]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [44]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [41]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [45]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [46]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [47]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [48]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [49]
Gefitinib DM15F0X Colon adenocarcinoma Approved [50]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [51]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [52]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [58]
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Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [62]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Leflunomide DMR8ONJ Arthritis FA20 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [66]
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Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [67]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [73]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [74]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [66]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [79]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [84]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [85]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [89]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [90]
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Drug(s) Affected By 5-hydroxytryptamine receptor 3A (HTR3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [92]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [93]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [94]
Metoclopramide DMFA5MY Nausea MD90 Approved [95]
Capsaicin DMGMF6V Back pain ME84.Z Approved [4]
Hydromorphone DMHP21E Back pain ME84.Z Approved [96]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [97]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [93]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [92]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [105]
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Drug(s) Affected By NADPH oxidase 1 (NOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [106]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [107]
Arsenic DMTL2Y1 N. A. N. A. Approved [108]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [109]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [109]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [110]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [109]
Acteoside DM0YHKB Nephritis GB40 Terminated [111]
U0126 DM31OGF Discovery agent N.A. Investigative [112]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Long transient receptor potential channel 7 (TRPM7) TTFPVZO TRPM7_HUMAN Blocker (channel blocker) [2]
Transient receptor potential cation channel V3 (TRPV3) TT946IA TRPV3_HUMAN Activator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-hydroxytryptamine receptor 3A (HTR3A) OTAIV1AK 5HT3A_HUMAN Gene/Protein Processing [4]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Post-Translational Modifications [7]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Protein Interaction/Cellular Processes [8]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Post-Translational Modifications [7]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) OTRAFFX2 GPX4_HUMAN Protein Interaction/Cellular Processes [8]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Protein Interaction/Cellular Processes [7]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Post-Translational Modifications [7]

References

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3 Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
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27 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
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30 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
31 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
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34 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
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41 Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol. 2011 Jun 20;24(6):950-9. doi: 10.1021/tx200123z. Epub 2011 May 25.
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49 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
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53 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
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55 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
56 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
57 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
58 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
59 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
60 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
61 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
62 The psychoactive substance of cannabis 9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1988-1994. doi: 10.1016/j.bbagen.2018.06.008. Epub 2018 Jun 19.
63 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
64 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
65 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
66 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
67 Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
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