Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ7YDS)

• Drug Name: Dexfenfluramine Drug Info
• Synonyms: DEXFENFLURAN; Dexfenfluramine (INN); Redux (TN); (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine; (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Withdrawn from market	[1]

• Therapeutic Class: Appetite Depressants
• Cross-matching ID:
  PubChem CID: 66265
  ChEBI ID: CHEBI:439329
  CAS Number: CAS 3239-44-9
  TTD Drug ID: DMJ7YDS
  INTEDE Drug ID: DR0466

Molecule-Related Drug Atlas

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[6]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[7]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[8]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[9]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[10]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[11]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[7]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[7]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[7]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[12]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[13]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[21]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[27]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[28]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[29]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[30]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[3]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[4]

References

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