Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKINJO)

Drug Name
Gentamicin Drug Info
Synonyms
Alcomicin; Apogen; Bristagen; Cidomycin; GENTAMYCIN; Garamycin; Garasol; Gentacidin; Gentacycol; Gentafair; Gentak; Gentamar; Gentamicina; Gentamicine; Gentamicins; Gentamicinum; Gentamycinum; Gentavet; Gentocin; Jenamicin; Refobacin; Uromycine; Garamycin Otic Solution; Genoptic Liquifilm; Gentamcin Sulfate; Gentamicin sulphate sterile; Refobacin TM; Gentamicin C1; G-Mycin; G-Myticin; Garamycin (TN); Gentamicin (BAN); Gentamicin (TN); Gentamicina [INN-Spanish]; Gentamicine [INN-French]; Gentamicinum [INN-Latin];Gentamycin-creme; Gentamycin-creme [German]; Ocu-Mycin; Spectro-Genta; U-Gencin; Genoptic S.O.P.; O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine; (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-beta-L-lyxo-heptopyranoside; (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl (6x)-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-erythro-heptopyranoside; (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol; 4,6-diamino-3-{[3-deoxy-4-c-methyl-3-(methylamino)pentopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)heptopyranoside
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1] , [2]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
3467
CAS Number
CAS 1403-66-3
TTD Drug ID
DMKINJO
VARIDT Drug ID
DR01198
INTEDE Drug ID
DR2174
ACDINA Drug ID
D01123

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Aminoglycoside O-phosphotransferase (aphA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tobramycin DMUI0CH Bacterial infection 1A00-1C4Z Approved [5]
Framycetin DMF8DNE Acute liver failure DB91 Approved [5]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [5]
Amikacin DM5PDRB Bacterial infection 1A00-1C4Z Approved [5]
Kanamycin DMITFB8 Pulmonary tuberculosis 1B10.Z Approved [5]
Streptomycin DMSRXVM Endocarditis BB40-BA42 Approved [5]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Aminoglycoside phosphotransferase (aph-Ib)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tobramycin DMUI0CH Bacterial infection 1A00-1C4Z Approved [4]
Kanamycin DMITFB8 Pulmonary tuberculosis 1B10.Z Approved [4]
Sisomicin DM92P0F Cystitis GC00 Approved [8]
Dibekacin DMTX0PZ Respiratory infection CA07-CA4Z Phase 4 [8]
Drug(s) Metabolized By Kanamycin/gentamycin-resistance enzyme (aacA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tobramycin DMUI0CH Bacterial infection 1A00-1C4Z Approved [4]
Kanamycin DMITFB8 Pulmonary tuberculosis 1B10.Z Approved [4]
Drug(s) Metabolized By Endoglucanase Y (EGY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [7]
Kanamycin DMITFB8 Pulmonary tuberculosis 1B10.Z Approved [7]
Streptomycin DMSRXVM Endocarditis BB40-BA42 Approved [7]
Bacitracin DMD2871 N. A. N. A. Approved [7]
Amikacin DM5PDRB Bacterial infection 1A00-1C4Z Approved [7]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [7]
Kanamycin DMITFB8 Pulmonary tuberculosis 1B10.Z Approved [7]
Streptomycin DMSRXVM Endocarditis BB40-BA42 Approved [7]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [9]
Tobramycin DMUI0CH Bacterial infection 1A00-1C4Z Approved [10]
TP-434 DM5A31S Intra-abdominal infection 1A40 Approved [11]
Doxycycline DM7ICNU Advanced gum disease DA0D Approved [3]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [12]
Sarecycline DMLZNIQ Acne vulgaris ED80 Approved [13]
ME1100 DM39PSZ Bacterial pneumonia CA40.0 Phase 1 [14]
TP-6076 DM5RIT8 Enterobacteriaceae infection MG50.C Phase 1 [15]
TP-271 DM3PJSE Pneumonia CA40 Phase 1 [16]
TP 6076 DMD0NA1 Multidrug resistant infection MG51 Phase 1 [15]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA) TTOVFH2 NOUNIPROTAC Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aminoglycoside phosphotransferase (aph-Ib) DE5WGIM A0A075C7U3_CAMJU Substrate [4]
Aminoglycoside O-phosphotransferase (aphA6) DEWPAJD KKA6_ACIBA Substrate [5]
Kanamycin/gentamycin-resistance enzyme (aacA) DECXWN8 J3S7E2_CAMCO Substrate [4]
Aminoglycoside 6'-N-acetyltransferase (aacA) DE48UAX C5MQW3_KLEPO Substrate [6]
Endoglucanase Y (EGY) DE2M583 A0A256VAC0_LACRE Substrate [7]
Endoglucanase Y (EGY) DE2AZTG A0A256VAC0_LACRE Substrate [7]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2427).
2 How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
5 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.
6 Detection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil. Biomedica. 2019 May 1;39(s1):135-149.
7 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.
8 Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.
9 The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74.
10 Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81.
11 The antibiotic arms race: current and emerging therapy for Klebsiella pneumoniae carbapenemase (KPC) - producing bacteria.Expert Opin Pharmacother. 2018 Oct 22:1-13.
12 Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204.
13 Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18.
14 ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health.
15 Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
16 Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.