Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML9W2V)

Drug Name

Amarylline Drug Info

Synonyms

Lycorine; BSPBio_0; CHEBI:6601; CHEMBL400092; EINECS 207-503-6; GNF-PF-4974; Galanthidine; (-)-Lycorine; 2188-68-3; 3,2.beta.-diol; I9Q105R5BU; KBioGR_000022; KBioSS_000022; Licorine; Likorin; Lycorine hydrochloride; NSC 401360; NSC401360; NSC683873; Narcissine; UNII-I9Q105R5BU

Indication

Disease Entry	ICD 11	Status	REF
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID: 72378
ChEBI ID: CHEBI:6601
CAS Number: CAS 476-28-8
TTD Drug ID: DML9W2V

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting MERS-CoV RNA-directed RNA polymerase (RdRp)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[4]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[5]
Galidesivir	DMG9C4I	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1 Trial	[4]
PMID31244113-compound-2c	DMZJWON	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[6]
PMID26048809-compound2	DMFNS7U	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[4]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[7]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[9]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[10]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[11]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
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Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[22]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[25]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[26]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[30]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[33]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[34]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[35]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[36]
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Drug(s) Affected By Semaphorin-4D (SEMA4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[45]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MERS-CoV RNA-directed RNA polymerase (RdRp)	TTOA6YT	R1AB_CVEMC (4378-5310)	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cadherin-5 (CDH5)	OTVX0E1Q	CADH5_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[3]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Gene/Protein Processing	[3]
Semaphorin-4D (SEMA4D)	OTJ5WDV9	SEM4D_HUMAN	Gene/Protein Processing	[3]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Gene/Protein Processing	[3]

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