Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPUFDS)

• Drug Name: GLUTARATE Drug Info
• Synonyms: GLUTARIC ACID; Pentanedioic acid; 110-94-1; 1,5-Pentanedioic acid; 1,3-Propanedicarboxylic acid; Pentandioic acid; glutarate; n-Pyrotartaric acid; UNII-H849F7N00B; propane-1,3-dicarboxylic acid; Carboxylic acids, di-, C4-6; HSDB 5542; Glutaric acid, 99%; Carboxylic acids, C6-18 and C5-15-di-; NSC 9238; EINECS 203-817-2; (C4-C6) Dibasic acids; BRN 1209725; AI3-24247; CHEBI:17859; NSC9238; JFCQEDHGNNZCLN-UHFFFAOYSA-N; H849F7N00B; MFCD00004410; DSSTox_CID_1654; DSSTox_RID_76266; DSSTox_GSID_21654; CAS-110-94-1; Pentandioate; Glutarsaeure

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 743
  ChEBI ID: CHEBI:17859
  CAS Number: CAS 110-94-1
  TTD Drug ID: DMPUFDS
  VARIDT Drug ID: DR00083

Molecule-Related Drug Atlas

Drug(s) Targeting Solute carrier family 22 member 8 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[1]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[6]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[1]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1]
ADIPATE	DM2XI09	Discovery agent	N.A.	Investigative	[1]
HEPTANOATE	DMGEO8N	Discovery agent	N.A.	Investigative	[1]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[9]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[10]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[10]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[10]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[11]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[12]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[13]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[14]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[16]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[16]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[16]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[18]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[16]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[3]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[16]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[20]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[21]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[22]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[22]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[23]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[23]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[24]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[5]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[5]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[5]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[5]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[5]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[5]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[22]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 22 member 8 (SLC22A8)	TTTQR47	S22A8_HUMAN	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Gene/Protein Processing	[3]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Regulation of Drug Effects	[4]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Regulation of Drug Effects	[5]

References

• [1] Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53.
• [2] Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55.
• [3] Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. Toxicol In Vitro. 2017 Oct;44:27-35.
• [4] The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. J Biol Chem. 2007 May 4;282(18):13402-9. doi: 10.1074/jbc.M609849200. Epub 2007 Mar 12.
• [5] Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8.
• [6] Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158.
• [7] The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9.
• [8] Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9.
• [9] Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8.
• [10] Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
• [11] Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7.
• [12] Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76.
• [13] Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.
• [14] Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem. 2004;14(3):177-86.
• [15] P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
• [16] Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
• [17] Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291. doi: 10.1093/toxsci/kfaa033.
• [18] Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicol Lett. 2023 Apr 15;379:48-55. doi: 10.1016/j.toxlet.2023.03.007. Epub 2023 Mar 22.
• [19] Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
• [20] Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol In Vitro. 2015 Feb;29(1):251-8. doi: 10.1016/j.tiv.2014.10.019.
• [21] Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
• [22] A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
• [23] Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13.
• [24] Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30.
• [25] Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
• [26] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [27] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.