Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ1BE8)

• Drug Name: 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline Drug Info
• Synonyms: CHEMBL6310; 7-Methoxy-1,2,3,4-tetrahydro-beta-carboline; AC1LCCZT; 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline; 7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole; SCIRNASYBOGBOO-UHFFFAOYSA-N; BDBM50132097; ZINC13587968; AKOS004119616; 91566-22-2; 7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; Methyl 2,3,4,9-tetrahydro-1H-beta-carbolin-7-yl ether #

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 599482
  TTD Drug ID: DMQ1BE8

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2C (ADRA2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[3]
Dihydroergocristine	DM5SQ1G	Alcohol dependence	6C40.2	Approved	[4]
Brimonidine	DMQLT4N	Ocular hypertension	9C61.01	Approved	[5]
Amosulalol	DML8QSZ	Hypertension	BA00-BA04	Approved	[6]
Amezinium	DM6I2WQ	Hypotension	BA20-BA21	Approved	[7]
Propylhexedrine	DMTBW2O	Obesity	5B81	Approved	[8]
Tetrahydrozoline	DMT57WC	Ocular disease	1F00.1Z	Approved	[9]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[10]
Xylometazoline	DMKV32D	Allergic rhinitis	CA08.0	Phase 4	[11]
TNX-102	DMO1234	Fibromyalgia	MG30.01	Phase 3	[12]

Drug(s) Targeting Adrenergic receptor alpha-2A (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lofexidine	DM1WXA6	Heroin and opiate withdrawal	6C43	Approved	[13]
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[3]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[15]
DSP-1200	DM4WSHG	Depression	6A70-6A7Z	Phase 1	[16]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[17]
NMI-870	DMU596F	Sexual dysfunction	HA00-HA01	Discontinued in Phase 2	[18]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[19]
A-80426	DMBC3DG	N. A.	N. A.	Terminated	[20]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[21]

Drug(s) Targeting 5-HT 2A receptor (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[22]
Zotepine	DMF3VXA	Anxiety disorder	6B00-6B0Z	Approved	[23]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[24]
Flibanserin	DM70DTN	Mood disorder	6A60-6E23	Approved	[25]
Lurasidone hydrochloride	DMCVPXO	Schizophrenia	6A20	Approved	[26]
Aniracetam	DMOIFW0	Cerebrovascular ischaemia	8B1Z	Approved	[27]
lumateperone tosylate	DMQ8HOJ	Schizophrenia	6A20	Approved	[28]
Sarpogrelate	DMGLP6S	Diabetic complication	5A2Y	Approved	[29]
Pimavanserin	DMR7IVC	Parkinson disease	8A00.0	Approved	[30]
Zicronapine	DMP8ESD	Schizophrenia	6A20	Phase 3	[31]

Drug(s) Targeting Adrenergic receptor alpha-2B (ADRA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[3]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[15]
AGN-199981	DMP5Y1A	Neuropathic pain	8E43.0	Phase 2	[32]
Indoramin	DMNSJFD	Hypertension	BA00-BA04	Withdrawn from market	[33]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[17]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[19]
A-80426	DMBC3DG	N. A.	N. A.	Terminated	[20]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[21]
SK&F-104078	DMRADBU	N. A.	N. A.	Terminated	[33]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[34]

Drug(s) Targeting Monoamine oxidase type B (MAO-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selegiline hydrochloride	DM3VR1L	Parkinson disease	8A00.0	Approved	[35]
Phenelzine	DMHIDUE	Depression	6A70-6A7Z	Approved	[36]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[37]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[38]
Safinamide mesylate	DM0J2ZT	Parkinson disease	8A00.0	Approved	[39]
Rasagiline	DM3WKQ4	Parkinson disease	8A00.0	Approved	[40]
Sulphadoxine	DMZI2UF	Malaria	1F40-1F45	Approved	[41]
Pargyline	DMM0HR1	Hypertension	BA00-BA04	Approved	[42]
Indeloxazine	DMWO3N6	Dementia	6D80-6D86	Approved	[43]
Budipine	DMODHQI	Migraine	8A80	Approved	[44]

Drug(s) Targeting Monoamine oxidase type A (MAO-A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Moclobemide	DMNZWL7	Depression	6A70-6A7Z	Approved	[45]
Tranylcypromine	DMGB5RE	Major depressive disorder	6A70.3	Approved	[46]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[47]
Isocarboxazid	DMAF1NB	Depression	6A70-6A7Z	Approved	[48]
TRYPTAMINE	DMAFPHB	N. A.	N. A.	Phase 3	[49]
Psoralen	DMIZJ8M	N. A.	N. A.	Phase 3	[50]
CHF-3381	DMQ2O8V	Neuropathic pain	8E43.0	Phase 2	[32]
Ladostigil	DMJSY3Q	Alzheimer disease	8A20	Phase 2	[51]
CX157	DMS2WB5	Mood disorder	6A60-6E23	Phase 2	[52]
PIPERINE	DMYEAB1	Vitiligo	ED63.0	Phase 1/2	[53]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[2]
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

References

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