Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQF982)

Drug Name
AEW-541 Drug Info
Synonyms
AECDBHGVIIRMOI-UHFFFAOYSA-N; NVP-AEW541; 475489-16-8; 475488-34-7; AEW541; NVP-AEW 541; UNII-97QB5037VR; AEW 541; AVP-AEW541; 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; CHEMBL1614712; 97QB5037VR; 7-[TRANS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE; C27H29N5O; 7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, 7-[CIS-3-(1-AZETIDINYLMETHYL)CYCLOBUTYL]-5-[3-(PHENYLMETHOXY)PHENYL]-
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 1 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
11476171
CAS Number
CAS 475488-34-7
TTD Drug ID
DMQF982

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Insulin-like growth factor I receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Teprotumumab DM4L59B Graves disease 5A02.0 Approved [6]
Mecasermin DM1O3BY Growth failure LD2F.1Y Approved [7]
Somatomedin-1 DMZ9FAO Hormone deficiency 5A61.1 Approved [8]
OSI-906 DMHKZLF Solid tumour/cancer 2A00-2F9Z Phase 3 [9]
Rinfabate DML9FD4 Solid tumour/cancer 2A00-2F9Z Phase 2/3 [10]
MM-141 DM2RJ4D Pancreatic cancer 2C10 Phase 2 [11]
TT-100 DMZE6Y9 Non-small-cell lung cancer 2C25.Y Phase 2 [12]
AMG 479 DM0DRAZ Breast cancer 2C60-2C65 Phase 2 [13]
VPI-2690B DMUQZT4 Diabetic nephropathy GB61.Z Phase 2 [14]
AXL-1717 DMTQ1Y3 Solid tumour/cancer 2A00-2F9Z Phase 2 [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [16]
Human neutral insulin DMA5OBU Diabetic complication 5A2Y Approved [17]
Insulin Lyspro recombinant DM5XHVR Diabetic complication 5A2Y Approved [17]
Insulin, porcine DMO95XI Diabetic complication 5A2Y Approved [18]
Insulin recombinant DMYVP5G Diabetic complication 5A2Y Approved [17]
Metformin arginine-hemisuccinimide DMTPAM3 Type-2 diabetes 5A11 Approved [19]
Insulin-lispro DM4O90W Diabetic complication 5A2Y Approved [20]
Insulin-glulisine DMQI0FU Diabetic complication 5A2Y Approved [21]
Ryzodeq DMOFP18 Type-2 diabetes 5A11 Approved [22]
NN5401 DM0QV27 Diabetic complication 5A2Y Phase 3 [22]
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Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [29]
Testosterone DM7HUNW Hot flushes GA30 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [30]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [31]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [35]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [39]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
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Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Folic Acid DMEMBJC Colorectal carcinoma Approved [48]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [49]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [50]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [51]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [57]
Selenium DM25CGV N. A. N. A. Approved [58]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [25]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [59]
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Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Inhibitor [2]
Insulin-like growth factor I receptor (IGF1R) TTHRID2 IGF1R_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Protein Interaction/Cellular Processes [4]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Protein Interaction/Cellular Processes [4]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Post-Translational Modifications [4]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Post-Translational Modifications [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Gene/Protein Processing [5]

References

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