Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTDRPM)

• Drug Name: impromidine Drug Info
• Synonyms: SK&F-92676-A3

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 41376
  CAS Number: CAS 55273-05-7
  TTD Drug ID: DMTDRPM

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[5]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[6]
UR-63325	DME6X27	Allergic rhinitis	CA08.0	Phase 2	[7]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[8]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[9]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[10]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[11]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[12]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[3]
N-[3H]alpha-methylhistamine	DMWDCV1	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Histamine H2 receptor (H2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[14]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[15]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[15]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[16]
Betazole	DMUFGAY	Gastric secretory disorder	DD90	Approved	[17]
Ebrotidine	DMV5KR3	Duodenal ulcer	DA63	Withdrawn from market	[18]
Pibutidine	DMXSTRM	Ulcerative colitis	DD71	Discontinued in Phase 3	[19]
Osutidine	DMN7TL8	Duodenal ulcer	DA63	Discontinued in Phase 3	[20]
KU-1257	DMZMFX6	Duodenal ulcer	DA63	Discontinued in Phase 3	[21]
Lavoltidine	DMTY5VE	Gastroesophageal reflux disease	DA22.Z	Discontinued in Phase 2	[22]

Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[23]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[24]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[25]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[26]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[27]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[28]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[29]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[30]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[28]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[31]

Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[3]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[32]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[33]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[34]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[35]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[33]
Doxepin	DMPI98T	Anxiety		Approved	[36]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[33]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[37]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[2]
Histamine H2 receptor (H2R)	TTQHJ1K	HRH2_HUMAN	Agonist	[2]
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Agonist	[3]
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Agonist	[4]

References

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• [20] Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50.
• [21] Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33.
• [22] New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16.
• [23] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [24] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [25] Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
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• [28] SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
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• [34] Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
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