Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWALXQ)

Drug Name

bongkrek acid Drug Info

Synonyms

bongkrekic acid; flavotoxin A

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6433556
ChEBI ID: CHEBI:77742
CAS Number: CAS 11076-19-0
TTD Drug ID: DMWALXQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Adenine nucleotide translocator 1 (SLC25A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[6]
Di-Stearoyl-3-Sn-Phosphatidylcholine	DM0GQJ2	Discovery agent	N.A.	Investigative	[7]
Cardiolipin	DMCSMX4	Discovery agent	N.A.	Investigative	[8]
Carboxyatractyloside	DMEORTQ	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Affected By ADP/ATP translocase 2 (SLC25A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[13]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[14]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[18]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[24]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[28]
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Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[30]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[30]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[34]
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Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[35]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[35]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[35]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[41]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenine nucleotide translocator 1 (SLC25A4)	TTU5A6Q	ADT1_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[3]
ADP/ATP translocase 2 (SLC25A5)	OT1XIBMN	ADT2_HUMAN	Gene/Protein Processing	[4]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Gene/Protein Processing	[5]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Gene/Protein Processing	[3]

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References

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2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1062).
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37	Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
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41	(9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.