Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY1TLZ)

Drug Name
BAICALIN Drug Info
Synonyms
Baicalin; 21967-41-9; Baicalein 7-O-glucuronide; 7-D-Glucuronic acid-5,6-dihydroxyflavone; CHEBI:2981; CHEMBL485818; UNII-347Q89U4M5; 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; Baicalin hydrate; 347Q89U4M5; (2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide; BAICAILIN; beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; 31564-28-0
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Terminated [1]
Cross-matching ID
PubChem CID
64982
ChEBI ID
CHEBI:2981
CAS Number
CAS 21967-41-9
TTD Drug ID
DMY1TLZ
VARIDT Drug ID
DR00902

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prolyl endopeptidase (PREP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [7]
ALV-003 DMXSFA0 Coeliac disease DA95 Phase 2 [8]
ONO-1603 DMKIZAL Cognitive impairment 6D71 Phase 2 [9]
S-17092-1 DMYR1K8 Cognitive impairment 6D71 Phase 1 [10]
JTP-4819 DMI0UJS Cognitive impairment 6D71 Discontinued in Phase 2 [11]
Z-321 DMLO2QY Parkinson disease 8A00.0 Discontinued in Phase 1 [12]
Y-29794 DMLAVES N. A. N. A. Terminated [2]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [13]
Monothioglycerol DMENSOZ Discovery agent N.A. Investigative [13]
Z-Pro-Prolinal DM43O2U Discovery agent N.A. Investigative [14]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [15]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [16]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [17]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Ethacrynic acid DM60QMR Edema MG29 Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [23]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [24]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [25]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [25]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [25]
Capsaicin DMGMF6V Back pain ME84.Z Approved [26]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [27]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [28]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [29]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [31]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [32]
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Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [47]
Paclitaxel DMLB81S Breast carcinoma Approved [48]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [53]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
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Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Selenium DM25CGV N. A. N. A. Approved [63]
Epinephrine DM3KJBC Acute asthma CA23 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Panobinostat DM58WKG Chronic graft versus host disease Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [71]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
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Drug(s) Affected By Hepatocyte nuclear factor 1-alpha (HNF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Ethanol DMDRQZU Chronic pain MG30 Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [86]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [88]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [89]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [84]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Selenium DM25CGV N. A. N. A. Approved [63]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [96]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [97]
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Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [99]
Fructose DM43AN2 Vomiting MD90 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
SR141716A DMCO5JZ Obesity 5B81 Approved [104]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [105]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [106]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [107]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Propranolol DM79NTF Angina pectoris BA40 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [112]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [6]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [113]
Mebendazole DMO14SG Ascariasis 1F62 Approved [114]
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Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [116]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [119]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [121]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [122]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [123]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [53]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [124]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [125]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [126]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Meloxicam DM2AR7L Arthritis FA20 Approved [128]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [129]
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Drug(s) Affected By Transcription factor HES-1 (HES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Selenium DM25CGV N. A. N. A. Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [132]
Leflunomide DMR8ONJ Arthritis FA20 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
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Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Panobinostat DM58WKG Chronic graft versus host disease Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [136]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [6]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [137]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [140]
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Drug(s) Affected By Hepatocyte nuclear factor 3-beta (FOXA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [141]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [142]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [107]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [138]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [107]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [120]
Urethane DM7NSI0 N. A. N. A. Phase 4 [143]
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Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [145]
Leflunomide DMR8ONJ Arthritis FA20 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [113]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [141]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [146]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [147]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prolyl endopeptidase (PREP) TTNGKET PPCE_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [5]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [3]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [6]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) OTJQL0I3 HEY1_HUMAN Gene/Protein Processing [6]
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) OTU4J3ZI HEY2_HUMAN Gene/Protein Processing [6]

References

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