Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZDF0B)

• Drug Name: Aceclofenac Drug Info
• Synonyms: Airtal; Barracan; Biofenac; Bristaflam; Falcol; Gerbin; Preservex; YT-919

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 71771
  ChEBI ID: CHEBI:31159
  CAS Number: CAS 89796-99-6
  TTD Drug ID: DMZDF0B
  INTEDE Drug ID: DR0033

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase (COX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[8]
Dexibuprofen	DMFYBD0	Ankylosing spondylitis	FA92.0	Approved	[9]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[10]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[11]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[12]
Lornoxicam	DMYZFXN	Migraine	8A80	Approved	[13]
Morniflumate	DM9UTDE	Otitis media	AA80-AB0Z	Approved	[14]
Nepafenac	DMYK490	Osteoarthritis	FA00-FA05	Approved	[15]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[22]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[5]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[5]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[28]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[5]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase (COX)	TTK0943	PGH1_HUMAN; PGH2_HUMAN	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Gene/Protein Processing	[4]
L-selectin (SELL)	OT6RAJZR	LYAM1_HUMAN	Gene/Protein Processing	[5]

References

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