General Information of Drug Off-Target (DOT) (ID: OTYQA8A6)

DOT Name Ferritin light chain (FTL)
Synonyms Ferritin L subunit
Gene Name FTL
Related Disease
Hereditary hyperferritinemia with congenital cataracts ( )
Acute myelogenous leukaemia ( )
Benign prostatic hyperplasia ( )
Bone osteosarcoma ( )
Cataract ( )
Choreatic disease ( )
Colorectal carcinoma ( )
Depression ( )
Dystonia ( )
Gestational trophoblastic neoplasia ( )
Hemochromatosis ( )
Hepatitis B virus infection ( )
Hepatocellular carcinoma ( )
Hydatidiform mole ( )
Hypopigmentation of the skin ( )
Inflammatory bowel disease ( )
Iron metabolism disease ( )
Keloid ( )
L-ferritin deficiency ( )
Melanoma ( )
Mood disorder ( )
Movement disorder ( )
Neurodegeneration with brain iron accumulation ( )
Neuroferritinopathy ( )
Obesity ( )
Osteosarcoma ( )
Prostate cancer ( )
Prostate carcinoma ( )
Psychotic disorder ( )
Rheumatoid arthritis ( )
Trichohepatoenteric syndrome ( )
Adult glioblastoma ( )
Glioblastoma multiforme ( )
Head-neck squamous cell carcinoma ( )
Parkinsonian disorder ( )
Obsolete genetic hyperferritinemia without iron overload ( )
Amyotrophic lateral sclerosis ( )
Breast cancer ( )
Breast carcinoma ( )
Gastritis ( )
Hereditary hemochromatosis ( )
Osteoarthritis ( )
Venous thromboembolism ( )
UniProt ID
FRIL_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
2FFX; 2FG4; 2FG8; 3KXU; 4V6B; 5LG8; 6TR9; 6TS0; 6TS1; 6TSA; 6TSF; 6TSJ; 6WX6
Pfam ID
PF00210
Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
KEGG Pathway
Porphyrin metabolism (hsa00860 )
Ferroptosis (hsa04216 )
Necroptosis (hsa04217 )
Mineral absorption (hsa04978 )
Reactome Pathway
Golgi Associated Vesicle Biogenesis (R-HSA-432722 )
Neutrophil degranulation (R-HSA-6798695 )
Iron uptake and transport (R-HSA-917937 )
Scavenging by Class A Receptors (R-HSA-3000480 )

Molecular Interaction Atlas (MIA) of This DOT

43 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hereditary hyperferritinemia with congenital cataracts DISGL689 Definitive Autosomal dominant [1]
Acute myelogenous leukaemia DISCSPTN Strong Altered Expression [2]
Benign prostatic hyperplasia DISI3CW2 Strong Altered Expression [3]
Bone osteosarcoma DIST1004 Strong Biomarker [4]
Cataract DISUD7SL Strong Genetic Variation [5]
Choreatic disease DISH8K3M Strong Genetic Variation [6]
Colorectal carcinoma DIS5PYL0 Strong Altered Expression [7]
Depression DIS3XJ69 Strong Biomarker [8]
Dystonia DISJLFGW Strong Genetic Variation [9]
Gestational trophoblastic neoplasia DIS4EJNA Strong Biomarker [10]
Hemochromatosis DISAPY0H Strong Genetic Variation [11]
Hepatitis B virus infection DISLQ2XY Strong Biomarker [12]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [13]
Hydatidiform mole DISKNP7O Strong Altered Expression [10]
Hypopigmentation of the skin DIS39YKC Strong Altered Expression [14]
Inflammatory bowel disease DISGN23E Strong Altered Expression [15]
Iron metabolism disease DISWDM9J Strong Biomarker [16]
Keloid DISV09JY Strong Biomarker [17]
L-ferritin deficiency DISVZ41G Strong Autosomal dominant [18]
Melanoma DIS1RRCY Strong Biomarker [14]
Mood disorder DISLVMWO Strong Altered Expression [19]
Movement disorder DISOJJ2D Strong Biomarker [20]
Neurodegeneration with brain iron accumulation DISRK4DZ Strong Biomarker [21]
Neuroferritinopathy DIS0E4F3 Strong Autosomal dominant [18]
Obesity DIS47Y1K Strong Biomarker [22]
Osteosarcoma DISLQ7E2 Strong Biomarker [4]
Prostate cancer DISF190Y Strong Biomarker [23]
Prostate carcinoma DISMJPLE Strong Biomarker [23]
Psychotic disorder DIS4UQOT Strong Biomarker [24]
Rheumatoid arthritis DISTSB4J Strong Altered Expression [15]
Trichohepatoenteric syndrome DISL3ODF Strong Genetic Variation [25]
Adult glioblastoma DISVP4LU moderate Biomarker [26]
Glioblastoma multiforme DISK8246 moderate Biomarker [26]
Head-neck squamous cell carcinoma DISF7P24 moderate Altered Expression [27]
Parkinsonian disorder DISHGY45 moderate Genetic Variation [24]
Obsolete genetic hyperferritinemia without iron overload DIS165JG Supportive Autosomal dominant [1]
Amyotrophic lateral sclerosis DISF7HVM Limited Altered Expression [28]
Breast cancer DIS7DPX1 Limited Biomarker [29]
Breast carcinoma DIS2UE88 Limited Biomarker [29]
Gastritis DIS8G07K Limited Biomarker [30]
Hereditary hemochromatosis DISVG5MT Limited Biomarker [31]
Osteoarthritis DIS05URM Limited Biomarker [32]
Venous thromboembolism DISUR7CR Limited Biomarker [33]
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⏷ Show the Full List of 43 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Paclitaxel DMLB81S Approved Ferritin light chain (FTL) decreases the response to substance of Paclitaxel. [67]
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46 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Ferritin light chain (FTL). [34]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Ferritin light chain (FTL). [35]
Doxorubicin DMVP5YE Approved Doxorubicin increases the expression of Ferritin light chain (FTL). [36]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Ferritin light chain (FTL). [37]
Estradiol DMUNTE3 Approved Estradiol affects the expression of Ferritin light chain (FTL). [38]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Ferritin light chain (FTL). [39]
Temozolomide DMKECZD Approved Temozolomide decreases the expression of Ferritin light chain (FTL). [41]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of Ferritin light chain (FTL). [42]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide increases the expression of Ferritin light chain (FTL). [43]
Triclosan DMZUR4N Approved Triclosan increases the expression of Ferritin light chain (FTL). [44]
Selenium DM25CGV Approved Selenium increases the expression of Ferritin light chain (FTL). [45]
Menadione DMSJDTY Approved Menadione increases the expression of Ferritin light chain (FTL). [43]
Folic acid DMEMBJC Approved Folic acid affects the expression of Ferritin light chain (FTL). [46]
Cannabidiol DM0659E Approved Cannabidiol increases the expression of Ferritin light chain (FTL). [47]
Rosiglitazone DMILWZR Approved Rosiglitazone affects the expression of Ferritin light chain (FTL). [48]
Ethanol DMDRQZU Approved Ethanol increases the expression of Ferritin light chain (FTL). [49]
Etoposide DMNH3PG Approved Etoposide increases the expression of Ferritin light chain (FTL). [37]
Sodium lauryl sulfate DMLJ634 Approved Sodium lauryl sulfate increases the expression of Ferritin light chain (FTL). [50]
DTI-015 DMXZRW0 Approved DTI-015 decreases the expression of Ferritin light chain (FTL). [51]
Benzoic acid DMKB9FI Approved Benzoic acid increases the expression of Ferritin light chain (FTL). [50]
Gallium nitrate DMF9O6B Approved Gallium nitrate increases the expression of Ferritin light chain (FTL). [52]
Tecfidera DM2OVDT Approved Tecfidera increases the expression of Ferritin light chain (FTL). [53]
Amiodarone DMUTEX3 Phase 2/3 Trial Amiodarone increases the expression of Ferritin light chain (FTL). [54]
DNCB DMDTVYC Phase 2 DNCB increases the expression of Ferritin light chain (FTL). [50]
PEITC DMOMN31 Phase 2 PEITC increases the expression of Ferritin light chain (FTL). [55]
APR-246 DMNFADH Phase 2 APR-246 affects the expression of Ferritin light chain (FTL). [56]
Disulfiram DMCL2OK Phase 2 Trial Disulfiram increases the expression of Ferritin light chain (FTL). [50]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Ferritin light chain (FTL). [57]
Eugenol DM7US1H Patented Eugenol increases the expression of Ferritin light chain (FTL). [50]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Ferritin light chain (FTL). [58]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Ferritin light chain (FTL). [59]
Milchsaure DM462BT Investigative Milchsaure increases the expression of Ferritin light chain (FTL). [50]
Sulforaphane DMQY3L0 Investigative Sulforaphane increases the expression of Ferritin light chain (FTL). [60]
chloropicrin DMSGBQA Investigative chloropicrin increases the expression of Ferritin light chain (FTL). [61]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Ferritin light chain (FTL). [62]
methyl p-hydroxybenzoate DMO58UW Investigative methyl p-hydroxybenzoate increases the expression of Ferritin light chain (FTL). [63]
cinnamaldehyde DMZDUXG Investigative cinnamaldehyde increases the expression of Ferritin light chain (FTL). [61]
acrolein DMAMCSR Investigative acrolein increases the expression of Ferritin light chain (FTL). [61]
Lead acetate DML0GZ2 Investigative Lead acetate increases the expression of Ferritin light chain (FTL). [64]
1,6-hexamethylene diisocyanate DMLB3RT Investigative 1,6-hexamethylene diisocyanate increases the expression of Ferritin light chain (FTL). [61]
NSC-1771 DMNXDGQ Investigative NSC-1771 increases the expression of Ferritin light chain (FTL). [61]
Beta-D-Glucose DM5IHYP Investigative Beta-D-Glucose increases the expression of Ferritin light chain (FTL). [65]
CHLORANIL DMCHGF1 Investigative CHLORANIL increases the expression of Ferritin light chain (FTL). [66]
methyl salicylate DMKCG8H Investigative methyl salicylate increases the expression of Ferritin light chain (FTL). [50]
2-Propanol, Isopropanol DML5O0H Investigative 2-Propanol, Isopropanol increases the expression of Ferritin light chain (FTL). [50]
Citraconic acid DMCIM9A Investigative Citraconic acid increases the expression of Ferritin light chain (FTL). [53]
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⏷ Show the Full List of 46 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Arsenic DMTL2Y1 Approved Arsenic affects the methylation of Ferritin light chain (FTL). [40]
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References

1 A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload. Haematologica. 2009 Mar;94(3):335-9. doi: 10.3324/haematol.2008.000125. Epub 2009 Jan 27.
2 Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia.Eur J Haematol. 2019 Feb;102(2):131-142. doi: 10.1111/ejh.13183. Epub 2018 Nov 28.
3 Association of ferritin with prostate cancer.J BUON. 2017 May-Jun;22(3):766-770.
4 Decreased expression of ferritin light chain in osteosarcoma and its correlation with epithelial-mesenchymal transition.Eur Rev Med Pharmacol Sci. 2018 May;22(9):2580-2587. doi: 10.26355/eurrev_201805_14951.
5 A novel double nucleotide variant in the ferritin-L iron-responsive element in a Finnish patient with hereditary hyperferritinaemia-cataract syndrome.Acta Ophthalmol. 2018 Feb;96(1):95-99. doi: 10.1111/aos.13492. Epub 2017 Jun 21.
6 Neurodegeneration with brain iron accumulation.Handb Clin Neurol. 2011;100:161-72. doi: 10.1016/B978-0-444-52014-2.00009-4.
7 Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer.Carcinogenesis. 2020 Jun 17;41(4):467-477. doi: 10.1093/carcin/bgz181.
8 The relationship between depression and serum ferritin level.Eur J Clin Nutr. 2007 Apr;61(4):532-5. doi: 10.1038/sj.ejcn.1602542. Epub 2006 Oct 25.
9 Adult-onset generalized dystonia due to a mutation in the neuroferritinopathy gene.Mov Disord. 2005 Feb;20(2):243-5. doi: 10.1002/mds.20280.
10 Differential expression of insulin-like growth factor binding protein 1 and ferritin light polypeptide in gestational trophoblastic neoplasia: combined cDNA suppression subtractive hybridization and microarray study.Cancer. 2005 Dec 1;104(11):2409-16. doi: 10.1002/cncr.21483.
11 Raised serum ferritin concentration in hereditary hyperferritinemia cataract syndrome is not a marker for iron overload.Hepatology. 2014 Mar;59(3):1204-6. doi: 10.1002/hep.26681. Epub 2014 Jan 27.
12 Ferritin light chain and squamous cell carcinoma antigen 1 are coreceptors for cellular attachment and entry of hepatitis B virus.Int J Nanomedicine. 2012;7:827-34. doi: 10.2147/IJN.S27803. Epub 2012 Feb 16.
13 Genomewide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and proteincoding genes in hepatocellular carcinoma.Int J Oncol. 2019 Oct;55(4):860-878. doi: 10.3892/ijo.2019.4858. Epub 2019 Aug 14.
14 Ferritin light chain down-modulation generates depigmentation in human metastatic melanoma cells by influencing tyrosinase maturation.J Cell Physiol. 2006 Mar;206(3):843-8. doi: 10.1002/jcp.20543.
15 Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2150-5. doi: 10.1073/pnas.94.6.2150.
16 Characterization of the l-ferritin variant 460InsA responsible of a hereditary ferritinopathy disorder.Neurobiol Dis. 2006 Sep;23(3):644-52. doi: 10.1016/j.nbd.2006.05.004. Epub 2006 Jul 5.
17 Comparative proteomic analysis between normal skin and keloid scar.Br J Dermatol. 2010 Jun;162(6):1302-15. doi: 10.1111/j.1365-2133.2010.09660.x. Epub 2010 Feb 1.
18 The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
19 Aspirin increases ferroportin 1 expression by inhibiting hepcidin via the JAK/STAT3 pathway in interleukin 6-treated PC-12 cells.Neurosci Lett. 2018 Jan 1;662:1-5. doi: 10.1016/j.neulet.2017.10.001. Epub 2017 Oct 4.
20 Neuroferritinopathy.Int Rev Neurobiol. 2013;110:91-123. doi: 10.1016/B978-0-12-410502-7.00006-5.
21 Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.Neuropathol Appl Neurobiol. 2016 Apr;42(3):220-41. doi: 10.1111/nan.12242. Epub 2015 Jun 2.
22 The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.Mol Cell Endocrinol. 2014 Nov;397(1-2):34-41. doi: 10.1016/j.mce.2014.09.012. Epub 2014 Sep 16.
23 Screening, identification of prostate cancer urinary biomarkers and verification of important spots.Invest New Drugs. 2019 Oct;37(5):935-947. doi: 10.1007/s10637-018-0709-3. Epub 2019 Jan 4.
24 Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement. Neurology. 2005 Aug 23;65(4):603-5. doi: 10.1212/01.wnl.0000178224.81169.c2.
25 Variation in iron homeostasis genes between patients with ARDS and healthy control subjects.Chest. 2008 Jun;133(6):1302-1311. doi: 10.1378/chest.07-1117. Epub 2007 Nov 7.
26 Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway.PLoS One. 2016 Feb 12;11(2):e0149361. doi: 10.1371/journal.pone.0149361. eCollection 2016.
27 Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma.Oncol Lett. 2019 Jan;17(1):314-322. doi: 10.3892/ol.2018.9642. Epub 2018 Oct 30.
28 Elevated levels of ferritin in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.Acta Neurol Scand. 2017 Aug;136(2):145-150. doi: 10.1111/ane.12708. Epub 2016 Nov 1.
29 Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.Int J Oncol. 2013 Nov;43(5):1481-6. doi: 10.3892/ijo.2013.2063. Epub 2013 Aug 20.
30 The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.Microb Pathog. 2019 Jan;126:157-164. doi: 10.1016/j.micpath.2018.10.039. Epub 2018 Oct 31.
31 Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population.Blood Cells Mol Dis. 2016 Oct;61:10-5. doi: 10.1016/j.bcmd.2016.07.004. Epub 2016 Jul 22.
32 Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance.Mol Cell Proteomics. 2009 Jan;8(1):172-89. doi: 10.1074/mcp.M800292-MCP200. Epub 2008 Sep 9.
33 Plasma hepcidin is associated with future risk of venous thromboembolism.Blood Adv. 2018 Jun 12;2(11):1191-1197. doi: 10.1182/bloodadvances.2018018465.
34 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
35 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
36 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
37 Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells. Environ Toxicol. 2021 Aug;36(8):1654-1663. doi: 10.1002/tox.23161. Epub 2021 May 10.
38 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
39 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
40 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
41 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
42 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
43 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
44 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
45 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
46 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
47 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
48 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
49 Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
50 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
51 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
52 Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
53 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
54 Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023 Aug;39(4):1773-1793. doi: 10.1007/s10565-022-09783-5. Epub 2022 Dec 31.
55 Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
56 Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
57 Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
58 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
59 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
60 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
61 Gene expressions changes in bronchial epithelial cells: markers for respiratory sensitizers and exploration of the NRF2 pathway. Toxicol In Vitro. 2014 Mar;28(2):209-17.
62 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
63 Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
64 In vitro effects of lead on gene expression in neural stem cells and associations between up-regulated genes and cognitive scores in children. Environ Health Perspect. 2017 Apr;125(4):721-729.
65 Effects of Anaplasma phagocytophilum on host cell ferritin mRNA and protein levels. Infect Immun. 2005 Nov;73(11):7629-36. doi: 10.1128/IAI.73.11.7629-7636.2005.
66 Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res. 2014 Feb;42(3):1593-605. doi: 10.1093/nar/gkt1090. Epub 2013 Nov 8.
67 cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.