Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE073H6)

• DME Name: Prostaglandin G/H synthase 1 (COX-1) DME Info
• Gene Name: PTGS1

Molecule-Related Drug & Molecule List

30 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[1]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[1]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[1]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[1]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[2]
Eletriptan	DMW649X	Migraine	8A80	Approved	[1]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[3]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[2]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[2]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[1]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[1]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[1]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[1]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[1]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[1]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[1]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[1]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[1]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[1]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[1]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[1]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[1]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[1]
Zaltoprofen	DM9RJH7	N. A.	N. A.	Phase 4	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Seratrodast	DMPNTDL	Allergic asthma	CA23.0	Discontinued in Phase 3	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[2]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[4]
BML3-C01	DMER2WS	N. A.	N. A.	Investigative	[2]
Eicosadienoic acid	DMVJK9W	N. A.	N. A.	Investigative	[2]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[2]

References

• [1] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [2] Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
• [3] Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
• [4] Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60.