Details of the Drug Combination

General Information of Drug Combination (ID: DC39K6V)

Drug Combination Name
Dasatinib Cyclophosphamide
Indication
Disease Entry Status REF
High grade ovarian serous adenocarcinoma Investigative [1]
Component Drugs Dasatinib   DMJV2EK Cyclophosphamide   DM4O2Z7
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: NCI\\/ADR-RES
Zero Interaction Potency (ZIP) Score: 4.05
Bliss Independence Score: 8.37
Loewe Additivity Score: 3.98
LHighest Single Agent (HSA) Score: 2.78

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Dasatinib
Disease Entry ICD 11 Status REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive N.A. Approved [2]
Brain disease 8C70-8E61 Approved [2]
Central nervous system disease 8A04-8D87 Approved [2]
Chronic myelogenous leukaemia 2A20.0 Approved [3]
Chronic myeloid leukaemia 2A20 Approved [4]
Glioblastoma 2A00 Approved [2]
Leukemia N.A. Approved [2]
Lung cancer 2C25.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [2]
Plasma cell myeloma 2A83.1 Approved [2]
Multiple myeloma 2A83 Phase 2 [3]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [5]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [5]
Dasatinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
LCK tyrosine protein kinase (LCK) TT860QF LCK_HUMAN Inhibitor [11]
Fyn tyrosine protein kinase (FYN) TT2B9KF FYN_HUMAN Inhibitor [11]
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Inhibitor [11]
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [11]
HUMAN fusion protein Bcr-Abl (Bcr-Abl) TTE63HY BCR_HUMAN/ABL1_HUMAN Inhibitor [5]
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Dasatinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [13]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [14]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [14]
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Dasatinib Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [15]
Dimethylaniline oxidase 3 (FMO3) DEP76YL FMO3_HUMAN Metabolism [16]
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Dasatinib Interacts with 453 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Affects Binding [8]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) OTB6YLFT ENPP3_HUMAN Decreases Expression [8]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Phosphorylation [8]
CD63 antigen (CD63) OT2UGZA9 CD63_HUMAN Decreases Expression [8]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Affects Binding [8]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Binding [8]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Decreases Expression [8]
Tyrosine-protein kinase CSK (CSK) OTP03OD0 CSK_HUMAN Affects Binding [8]
Tyrosine-protein kinase Tec (TEC) OTU6QJAJ TEC_HUMAN Affects Binding [8]
Tyrosine-protein kinase FRK (FRK) OTEKV1SC FRK_HUMAN Affects Binding [8]
Ephrin type-A receptor 5 (EPHA5) OTAM0CVX EPHA5_HUMAN Affects Binding [8]
Ephrin type-B receptor 4 (EPHB4) OTKLPVXJ EPHB4_HUMAN Affects Binding [8]
Sialomucin core protein 24 (CD164) OTZ7FIU8 MUC24_HUMAN Decreases Expression [8]
Amidophosphoribosyltransferase (PPAT) OTXK12ZB PUR1_HUMAN Affects Binding [8]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Affects Binding [8]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) OT0ALMEG M3K20_HUMAN Affects Binding [8]
ATP-dependent RNA helicase DDX39A (DDX39A) OT0Z6E1K DX39A_HUMAN Decreases Expression [9]
Cell division cycle 7-related protein kinase (CDC7) OT5133XY CDC7_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [9]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [9]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [9]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [9]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) OTU3TGQ9 RPC7_HUMAN Decreases Expression [9]
Fanconi anemia group A protein (FANCA) OTPEFJD4 FANCA_HUMAN Decreases Expression [9]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [9]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [9]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [9]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Decreases Expression [9]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [9]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Increases Expression [9]
NUAK family SNF1-like kinase 1 (NUAK1) OTLLHJJQ NUAK1_HUMAN Increases Expression [9]
Neuropilin-2 (NRP2) OTZL256E NRP2_HUMAN Increases Expression [9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [9]
Tetraspanin-2 (TSPAN2) OTTDPQF1 TSN2_HUMAN Increases Expression [9]
Leupaxin (LPXN) OTUNV3CK LPXN_HUMAN Decreases Expression [9]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [9]
DNA polymerase theta (POLQ) OTBHK0E6 DPOLQ_HUMAN Decreases Expression [9]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [9]
Glypican-4 (GPC4) OTUJ14DW GPC4_HUMAN Increases Expression [9]
Serpin B7 (SERPINB7) OTZ95LR2 SPB7_HUMAN Decreases Expression [9]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Decreases Expression [9]
Ribonuclease H2 subunit A (RNASEH2A) OT8G3G7K RNH2A_HUMAN Decreases Expression [9]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [9]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Decreases Expression [9]
Centrosomal protein of 152 kDa (CEP152) OTOKZR9B CE152_HUMAN Decreases Expression [9]
Potassium channel subfamily K member 2 (KCNK2) OTWBT8MG KCNK2_HUMAN Decreases Expression [9]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [9]
Structural maintenance of chromosomes protein 2 (SMC2) OT5S0DV4 SMC2_HUMAN Decreases Expression [9]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [9]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Increases Expression [9]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Expression [9]
Histone-lysine N-methyltransferase NSD2 (NSD2) OTQ6SW4R NSD2_HUMAN Decreases Expression [9]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Increases Expression [9]
Dihydrofolate reductase (DHFR) OT3DVIGM DYR_HUMAN Decreases Expression [9]
Complement C1r subcomponent (C1R) OTA0ZNIU C1R_HUMAN Increases Expression [9]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [9]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [9]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [9]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Increases Expression [9]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [9]
Alpha-crystallin B chain (CRYAB) OTY4JGYU CRYAB_HUMAN Increases Expression [9]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Decreases Expression [9]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Decreases Expression [9]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [9]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [9]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [9]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [9]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [9]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Expression [9]
Neurofilament medium polypeptide (NEFM) OT8VCBNF NFM_HUMAN Decreases Expression [9]
Laminin subunit beta-1 (LAMB1) OT6J9LJR LAMB1_HUMAN Increases Expression [9]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [9]
Matrix Gla protein (MGP) OTZWU3FU MGP_HUMAN Increases Expression [9]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [9]
Platelet-derived growth factor receptor beta (PDGFRB) OTYSNK9Q PGFRB_HUMAN Increases Expression [9]
Complement C1s subcomponent (C1S) OTCIZU2A C1S_HUMAN Increases Expression [9]
DNA polymerase alpha catalytic subunit (POLA1) OT1WXFVY DPOLA_HUMAN Decreases Expression [9]
Histone H2A.Z (H2AZ1) OT3KJJNQ H2AZ_HUMAN Decreases Expression [9]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Decreases Expression [9]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [9]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [9]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [9]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Decreases Expression [9]
Collagen alpha-1(XI) chain (COL11A1) OTB0DRMS COBA1_HUMAN Increases Expression [9]
Elastin (ELN) OTFSO7PG ELN_HUMAN Increases Expression [9]
Aggrecan core protein (ACAN) OTUOCW8K PGCA_HUMAN Increases Expression [9]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [9]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [9]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Decreases Expression [9]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [9]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) OT3MPPYX ENPP1_HUMAN Decreases Expression [9]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [9]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [9]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Decreases Expression [9]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [9]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [9]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [9]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [9]
Cardiac phospholamban (PLN) OTT3RRJN PPLA_HUMAN Increases Expression [9]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Decreases Expression [9]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Increases Expression [9]
Leiomodin-1 (LMOD1) OTZ2MEMG LMOD1_HUMAN Increases Expression [9]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [9]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [9]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [9]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [9]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Increases Expression [9]
Cyclin-dependent kinases regulatory subunit 2 (CKS2) OTPTMHIV CKS2_HUMAN Decreases Expression [9]
Histone H2B type 1-B (H2BC3) OT1BLFJO H2B1B_HUMAN Decreases Expression [9]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [9]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [9]
Syndecan-2 (SDC2) OTEEHY1D SDC2_HUMAN Increases Expression [9]
Replication factor C subunit 4 (RFC4) OTWALD2R RFC4_HUMAN Decreases Expression [9]
Replication factor C subunit 2 (RFC2) OTJ9N6BD RFC2_HUMAN Decreases Expression [9]
Thrombospondin-2 (THBS2) OTXET551 TSP2_HUMAN Increases Expression [9]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Increases Expression [9]
Myosin-11 (MYH11) OTVNVWY3 MYH11_HUMAN Increases Expression [9]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Increases Expression [9]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [9]
Flap endonuclease 1 (FEN1) OT6QGG7O FEN1_HUMAN Decreases Expression [9]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [9]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Increases Expression [9]
Replication factor C subunit 5 (RFC5) OTAD79RT RFC5_HUMAN Decreases Expression [9]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Decreases Expression [9]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [9]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [9]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [9]
Condensin-2 complex subunit D3 (NCAPD3) OTOZY2UL CNDD3_HUMAN Decreases Expression [9]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Increases Expression [9]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [9]
DNA mismatch repair protein Msh2 (MSH2) OT10H1AB MSH2_HUMAN Decreases Expression [9]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [9]
Glutathione S-transferase Mu 5 (GSTM5) OTMMBFY8 GSTM5_HUMAN Increases Expression [9]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [9]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [9]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [9]
DNA primase large subunit (PRIM2) OTGT0KTF PRI2_HUMAN Decreases Expression [9]
Thrombospondin-3 (THBS3) OTDKMUBD TSP3_HUMAN Increases Expression [9]
Regulator of G-protein signaling 4 (RGS4) OTG94HHL RGS4_HUMAN Decreases Expression [9]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Increases Expression [9]
Kinetochore-associated protein 1 (KNTC1) OTI2OOFN KNTC1_HUMAN Decreases Expression [9]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [9]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [9]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [9]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [9]
Calponin-1 (CNN1) OTVPG39Z CNN1_HUMAN Increases Expression [9]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [9]
Stanniocalcin-1 (STC1) OTGVVXYF STC1_HUMAN Decreases Expression [9]
High mobility group protein HMGI-C (HMGA2) OTBMBHHL HMGA2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [9]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Increases Expression [9]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [9]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [9]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [9]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [9]
Actin, gamma-enteric smooth muscle (ACTG2) OTRDWUO0 ACTH_HUMAN Increases Expression [9]
Actin, alpha cardiac muscle 1 (ACTC1) OTJU04B1 ACTC_HUMAN Increases Expression [9]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Increases Expression [9]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [9]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [9]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [9]
Histone H1.1 (H1-1) OTSS815G H11_HUMAN Decreases Expression [9]
Aldehyde oxidase (AOX1) OT2FZP6H AOXA_HUMAN Decreases Expression [9]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [9]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Increases Expression [9]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [9]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [9]
Lactadherin (MFGE8) OTQKE41R MFGM_HUMAN Increases Expression [9]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Increases Expression [9]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [9]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Increases Expression [9]
MAL-like protein (MALL) OTKGZ89D MALL_HUMAN Decreases Expression [9]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [9]
Centromere protein R (ITGB3BP) OT6Q7GR3 CENPR_HUMAN Decreases Expression [9]
Origin recognition complex subunit 1 (ORC1) OTHWU8IJ ORC1_HUMAN Decreases Expression [9]
Limbic system-associated membrane protein (LSAMP) OTYXVQX2 LSAMP_HUMAN Increases Expression [9]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [9]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Expression [9]
DNA polymerase alpha subunit B (POLA2) OTTWQ73N DPOA2_HUMAN Decreases Expression [9]
Fibroleukin (FGL2) OT8M3H72 FGL2_HUMAN Increases Expression [9]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Increases Expression [9]
Semaphorin-3A (SEMA3A) OTQJSV7W SEM3A_HUMAN Decreases Expression [9]
DNA replication licensing factor MCM6 (MCM6) OTKLIAWT MCM6_HUMAN Decreases Expression [9]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) OTX7MWW1 ITPR1_HUMAN Increases Expression [9]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [9]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [9]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Increases Expression [9]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [9]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [9]
Condensin complex subunit 1 (NCAPD2) OT8VGE2O CND1_HUMAN Decreases Expression [9]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [9]
SCL-interrupting locus protein (STIL) OT9799VN STIL_HUMAN Decreases Expression [9]
Pachytene checkpoint protein 2 homolog (TRIP13) OTFM3TI9 PCH2_HUMAN Decreases Expression [9]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [9]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [9]
Insulin-like growth factor-binding protein 7 (IGFBP7) OT1D416P IBP7_HUMAN Increases Expression [9]
Neuronal regeneration-related protein (NREP) OT2AZPKK NREP_HUMAN Increases Expression [9]
Prostacyclin synthase (PTGIS) OTT3RW6N PTGIS_HUMAN Increases Expression [9]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [9]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [9]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [9]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Increases Expression [9]
Flap endonuclease GEN homolog 1 (GEN1) OT1XFQXF GEN_HUMAN Decreases Expression [9]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [9]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) OTOBICRD SVEP1_HUMAN Increases Expression [9]
Borealin (CDCA8) OT17D55D BOREA_HUMAN Decreases Expression [9]
Protein LBH (LBH) OT87AT1X LBH_HUMAN Increases Expression [9]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [9]
Centromere protein W (CENPW) OTZL05QN CENPW_HUMAN Decreases Expression [9]
Shugoshin 1 (SGO1) OTIP6IRN SGO1_HUMAN Decreases Expression [9]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [9]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Decreases Expression [9]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [9]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [9]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [9]
Protein FAM72D (FAM72D) OTCQVOXB FA72D_HUMAN Decreases Expression [9]
Repulsive guidance molecule B (RGMB) OT2DROYU RGMB_HUMAN Decreases Expression [9]
STEAP family member 1B (STEAP1B) OTZJDFWK STEAL_HUMAN Decreases Expression [9]
Mis18-binding protein 1 (MIS18BP1) OT41T0FB M18BP_HUMAN Decreases Expression [9]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RFWD3 (RFWD3) OTDUULBQ RFWD3_HUMAN Decreases Expression [9]
Podocan-like protein 1 (PODNL1) OTL72ES9 PONL1_HUMAN Increases Expression [9]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [9]
Neutral cholesterol ester hydrolase 1 (NCEH1) OTZ66CKX NCEH1_HUMAN Decreases Expression [9]
Fidgetin-like protein 1 (FIGNL1) OTKII63K FIGL1_HUMAN Decreases Expression [9]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [9]
Serine protease FAM111B (FAM111B) OT9IQ9NV F111B_HUMAN Decreases Expression [9]
Protein FAM180A (FAM180A) OTKQ7XUG F180A_HUMAN Decreases Expression [9]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Increases Expression [9]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [9]
ALK and LTK ligand 1 (ALKAL1) OTZGAZ79 ALKL1_HUMAN Increases Expression [9]
Protein MMS22-like (MMS22L) OTJI0HM9 MMS22_HUMAN Decreases Expression [9]
Centrosomal protein of 128 kDa (CEP128) OT922YCJ CE128_HUMAN Decreases Expression [9]
DNA-binding protein RFX8 (RFX8) OT27SFGQ RFX8_HUMAN Decreases Expression [9]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [9]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [9]
Treslin (TICRR) OT2HKWOC TICRR_HUMAN Decreases Expression [9]
MAM domain-containing protein 2 (MAMDC2) OT4GICNY MAMC2_HUMAN Increases Expression [9]
LisH domain-containing protein ARMC9 (ARMC9) OT0MZER2 ARMC9_HUMAN Increases Expression [9]
Rho GTPase-activating protein 22 (ARHGAP22) OTXUQEFL RHG22_HUMAN Decreases Expression [9]
Podocan (PODN) OTV3P7P5 PODN_HUMAN Increases Expression [9]
Schlafen family member 11 (SLFN11) OTJWFPMY SLN11_HUMAN Decreases Expression [9]
Amphoterin-induced protein 2 (AMIGO2) OTPAIT1O AMGO2_HUMAN Increases Expression [9]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [9]
Myopalladin (MYPN) OTHTOFDU MYPN_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Decreases Expression [9]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) OT4RZV2M IQGA3_HUMAN Decreases Expression [9]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [9]
GAS2-like protein 3 (GAS2L3) OTWPVI29 GA2L3_HUMAN Decreases Expression [9]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [9]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [9]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Increases Expression [9]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [9]
CD302 antigen (CD302) OTX580VU CD302_HUMAN Increases Expression [9]
Spindle and kinetochore-associated protein 3 (SKA3) OTLHEVJD SKA3_HUMAN Decreases Expression [9]
DNA damage-induced apoptosis suppressor protein (DDIAS) OTTGG2PM DDIAS_HUMAN Decreases Expression [9]
Cytoskeleton-associated protein 2-like (CKAP2L) OT4T73GG CKP2L_HUMAN Decreases Expression [9]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Decreases Expression [9]
Lung adenoma susceptibility protein 2 (C18ORF54) OT4WJKTF LAS2_HUMAN Decreases Expression [9]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [9]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [9]
Centromere protein L (CENPL) OT7P006B CENPL_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 18 (ARHGAP18) OTYMJP6H RHG18_HUMAN Decreases Expression [9]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [9]
Aminopeptidase O (AOPEP) OT0MMANL AMPO_HUMAN Increases Expression [9]
Junction-mediating and -regulatory protein (JMY) OTH5FFVK JMY_HUMAN Increases Expression [9]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [9]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [9]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1) OTVXEF85 MDGA1_HUMAN Increases Expression [9]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) OTQK3M9X ABHD4_HUMAN Increases Expression [9]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [9]
Protein CIP2A (CIP2A) OTVS2GXA CIP2A_HUMAN Decreases Expression [9]
Sodium-dependent phosphate transporter 1 (SLC20A1) OTC3D894 S20A1_HUMAN Decreases Expression [9]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [9]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2) OTIBDGQC BMAL2_HUMAN Decreases Expression [9]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [9]
Serine protease HTRA1 (HTRA1) OTR8ACBF HTRA1_HUMAN Increases Expression [9]
Hyaluronan synthase 2 (HAS2) OTTD3PAL HYAS2_HUMAN Decreases Expression [9]
Neogenin (NEO1) OTGJ1997 NEO1_HUMAN Increases Expression [9]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [9]
F-box only protein 32 (FBXO32) OTUE978R FBX32_HUMAN Increases Expression [9]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [9]
Transcription factor E2F7 (E2F7) OTWW358N E2F7_HUMAN Decreases Expression [9]
Spindle and kinetochore-associated protein 1 (SKA1) OTDYJ12A SKA1_HUMAN Decreases Expression [9]
Mdm2-binding protein (MTBP) OTWLCW9C MTBP_HUMAN Decreases Expression [9]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Decreases Expression [9]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase greatwall (MASTL) OTQ7YKK5 GWL_HUMAN Decreases Expression [9]
Centromere protein N (CENPN) OTRO7XPD CENPN_HUMAN Decreases Expression [9]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [9]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [9]
Leucine-rich repeat protein 1 (LRR1) OTSWDXVY LLR1_HUMAN Decreases Expression [9]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1) OT5TS6P7 PCMD1_HUMAN Increases Expression [9]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2) OTB71I02 DCBD2_HUMAN Decreases Expression [9]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [9]
ATPase family AAA domain-containing protein 5 (ATAD5) OTI8ABKF ATAD5_HUMAN Decreases Expression [9]
Hemicentin-1 (HMCN1) OTLZAS0P HMCN1_HUMAN Increases Expression [9]
Hyaluronan and proteoglycan link protein 3 (HAPLN3) OTB853Z1 HPLN3_HUMAN Increases Expression [9]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Decreases Expression [9]
Cell division cycle-associated protein 3 (CDCA3) OTUI8QK3 CDCA3_HUMAN Decreases Expression [9]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [9]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [9]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Increases Expression [9]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [9]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [9]
Mitochondrial genome maintenance exonuclease 1 (MGME1) OTC5LPXX MGME1_HUMAN Decreases Expression [9]
Synaptotagmin-15 (SYT15) OT7Q088G SYT15_HUMAN Increases Expression [9]
Hephaestin (HEPH) OTZ2F15Z HEPH_HUMAN Increases Expression [9]
DNA replication complex GINS protein SLD5 (GINS4) OTCVOO3S SLD5_HUMAN Decreases Expression [9]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [9]
Protein PIMREG (PIMREG) OTKC8T3E PIMRE_HUMAN Decreases Expression [9]
Nucleoporin NDC1 (NDC1) OTF2GQC1 NDC1_HUMAN Decreases Expression [9]
Centromere protein O (CENPO) OTXAH83Y CENPO_HUMAN Decreases Expression [9]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [9]
TIMELESS-interacting protein (TIPIN) OT9PZHXV TIPIN_HUMAN Decreases Expression [9]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [9]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [9]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [9]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [9]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Increases Expression [9]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [9]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [9]
Centromere protein H (CENPH) OTPOO9LK CENPH_HUMAN Decreases Expression [9]
Kinetochore-associated protein DSN1 homolog (DSN1) OTHROI0H DSN1_HUMAN Decreases Expression [9]
Uncharacterized protein C1orf198 (C1ORF198) OTK3L4G7 CA198_HUMAN Increases Expression [9]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2) OTFTH6ZY GAPR1_HUMAN Increases Expression [9]
Very long chain fatty acid elongase 6 (ELOVL6) OTB26UJJ ELOV6_HUMAN Decreases Expression [9]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Increases Expression [9]
Gremlin-2 (GREM2) OTE91EWT GREM2_HUMAN Increases Expression [9]
Metal transporter CNNM2 (CNNM2) OTZHO8WU CNNM2_HUMAN Increases Expression [9]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [9]
Claspin (CLSPN) OTZZXNDK CLSPN_HUMAN Decreases Expression [9]
Mineralization regulator ANKH (ANKH) OTCN25R5 ANKH_HUMAN Increases Expression [9]
Ribonucleoprotein PTB-binding 2 (RAVER2) OT0MDL7K RAVR2_HUMAN Increases Expression [9]
Neurexin-3-beta (NRXN3) OTJ0I7HJ NRX3B_HUMAN Increases Expression [9]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Increases Expression [9]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [9]
Phospholipid scramblase 4 (PLSCR4) OT2AMYLY PLS4_HUMAN Increases Expression [9]
Lymphoid-specific helicase (HELLS) OTVVV668 HELLS_HUMAN Decreases Expression [9]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) OTALLHT1 FIRRM_HUMAN Decreases Expression [9]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [9]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [9]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [9]
Tyrosyl-DNA phosphodiesterase 1 (TDP1) OTYINMBR TYDP1_HUMAN Decreases Expression [9]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [9]
Histone chaperone ASF1B (ASF1B) OTKXX12I ASF1B_HUMAN Decreases Expression [9]
PCNA-interacting partner (PARPBP) OTPZDGW7 PARI_HUMAN Decreases Expression [9]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [9]
Dapper homolog 1 (DACT1) OT19Z704 DACT1_HUMAN Increases Expression [9]
Protein Mis18-alpha (MIS18A) OTD80K5X MS18A_HUMAN Decreases Expression [9]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [9]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Decreases Expression [9]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Increases Expression [9]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) OT1PAIN0 CACO1_HUMAN Increases Expression [9]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [9]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Increases Expression [9]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B) OTHLNI51 ABC3B_HUMAN Decreases Expression [9]
STEAP1 protein (STEAP1) OTJMW5R9 STEA1_HUMAN Decreases Expression [9]
Carboxypeptidase A4 (CPA4) OT66MP0F CBPA4_HUMAN Decreases Expression [9]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [9]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [9]
Angiopoietin-related protein 2 (ANGPTL2) OTB6JG41 ANGL2_HUMAN Increases Expression [9]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Increases Expression [9]
Protein HEG homolog 1 (HEG1) OT3CUXA7 HEG1_HUMAN Increases Expression [9]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [9]
Synaptopodin-2 (SYNPO2) OTC3U0YH SYNP2_HUMAN Increases Expression [9]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) OT953SV2 ATS5_HUMAN Increases Expression [9]
Protein timeless homolog (TIMELESS) OTD8DCBJ TIM_HUMAN Decreases Expression [9]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [9]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [9]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) OTEU05TX PPR3C_HUMAN Increases Expression [9]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [9]
DNA replication complex GINS protein PSF2 (GINS2) OT974IYI PSF2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase 38-like (STK38L) OTI00JVW ST38L_HUMAN Increases Expression [9]
Small kinetochore-associated protein (KNSTRN) OTYA7UXS SKAP_HUMAN Decreases Expression [9]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [9]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [9]
Carboxypeptidase Q (CPQ) OTTNZNLD CBPQ_HUMAN Increases Expression [9]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [9]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) OTMRW5U5 IRAG1_HUMAN Increases Expression [9]
Adenylate kinase isoenzyme 5 (AK5) OTTGXLOT KAD5_HUMAN Decreases Expression [9]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [17]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) OTFBFPV4 ADAS_HUMAN Increases Expression [18]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [18]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [18]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Phosphorylation [18]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [18]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [18]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [18]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Increases Expression [19]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [20]
Tyrosine-protein kinase ABL1 (ABL1) OT09YVXH ABL1_HUMAN Decreases Activity [21]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [19]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [22]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [23]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [23]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [19]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [23]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Activity [24]
Interleukin-5 (IL5) OTAFPSCO IL5_HUMAN Decreases Expression [23]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Decreases Expression [25]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Decreases Activity [10]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Decreases Phosphorylation [26]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [23]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Increases Expression [27]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Activity [25]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [23]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [28]
Mast/stem cell growth factor receptor Kit (KIT) OTHUY3VZ KIT_HUMAN Decreases Phosphorylation [29]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Increases Expression [19]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Activity [21]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Decreases Expression [23]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Activity [25]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [23]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Decreases Expression [23]
Platelet-derived growth factor receptor alpha (PDGFRA) OTDJXUCN PGFRA_HUMAN Decreases Phosphorylation [30]
C-C motif chemokine 1 (CCL1) OT23NON8 CCL1_HUMAN Decreases Expression [23]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [31]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [10]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [23]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [31]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Phosphorylation [29]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Phosphorylation [32]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [28]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [21]
Tyrosine-protein kinase ABL2 (ABL2) OTS8F4GD ABL2_HUMAN Affects Binding [33]
Crk-like protein (CRKL) OTOYSD1R CRKL_HUMAN Decreases Phosphorylation [34]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [31]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [23]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Phosphorylation [32]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Cleavage [10]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [35]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Decreases Expression [23]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [23]
Mothers against decapentaplegic homolog 3 (SMAD3) OTNA96MR SMAD3_HUMAN Decreases Phosphorylation [22]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Phosphorylation [19]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Phosphorylation [31]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Decreases Expression [23]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [10]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [10]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [35]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1) OTF91GTL FIP1_HUMAN Decreases Phosphorylation [30]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Phosphorylation [36]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) OTYRXD2T PMYT1_HUMAN Decreases Activity [37]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [38]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Affects Localization [20]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Response To Substance [31]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Decreases Response To Substance [39]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Decreases Response To Substance [39]
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⏷ Show the Full List of 453 DOT(s)
Indication(s) of Cyclophosphamide
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [6]
Central nervous system neoplasm N.A. Approved [6]
Glioblastoma 2A00 Approved [6]
Immunodeficiency 4A00-4A85 Approved [6]
Inflammatory breast cancer 2C62 Approved [6]
Lupus nephritis 4A40.0Y Approved [6]
Lymphoma 2A80-2A86 Approved [6]
Multiple sclerosis 8A40 Approved [6]
Mycosis fungoides 2B01 Approved [6]
Plasma cell myeloma 2A83.1 Approved [6]
Solid tumour/cancer 2A00-2F9Z Approved [7]
Classic Hodgkin lymphoma N.A. Investigative [6]
Neuroblastoma 2D11.2 Investigative [6]
Retinoblastoma 2D02.2 Investigative [6]
Scleroderma 4A42 Investigative [6]
Cyclophosphamide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [46]
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Cyclophosphamide Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [47]
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Cyclophosphamide Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [48]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Metabolism [49]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [50]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [49]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [51]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [52]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [53]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [54]
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⏷ Show the Full List of 8 DME(s)
Cyclophosphamide Interacts with 225 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Increases Activity [55]
Cytochrome P450 2C18 (CYP2C18) OTY687L9 CP2CI_HUMAN Increases Activity [55]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [56]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Hydroxylation [57]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Increases ADR [40]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Increases Metabolism [58]
Cholinesterase (BCHE) OTOH3WQ9 CHLE_HUMAN Decreases Activity [59]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [60]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Expression [60]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Decreases Expression [61]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Increases Expression [61]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [61]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11) OTBOY3WH KBTBB_HUMAN Decreases Expression [61]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Increases Expression [61]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Decreases Expression [61]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [61]
Tyrosine-protein kinase Fyn (FYN) OTLSLVZS FYN_HUMAN Increases Expression [61]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Increases Expression [61]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Increases Expression [61]
SPARC (SPARC) OTPN90H0 SPRC_HUMAN Increases Expression [61]
Pro-cathepsin H (CTSH) OTLFL0DG CATH_HUMAN Increases Expression [61]
Non-secretory ribonuclease (RNASE2) OT8Z4FNE RNAS2_HUMAN Decreases Expression [61]
Transcriptional regulator ERG (ERG) OTOTX9VU ERG_HUMAN Increases Expression [61]
Tissue factor (F3) OT3MSU3B TF_HUMAN Decreases Expression [61]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) OTVT146E CX7A2_HUMAN Decreases Expression [61]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [61]
Bactericidal permeability-increasing protein (BPI) OTNN9LJ5 BPI_HUMAN Decreases Expression [61]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Decreases Expression [61]
Interferon-induced GTP-binding protein Mx2 (MX2) OT05NF37 MX2_HUMAN Decreases Expression [61]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Increases Expression [61]
Myeloblastin (PRTN3) OT72MHP7 PRTN3_HUMAN Decreases Expression [61]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [61]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Decreases Expression [61]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Increases Expression [61]
Transmembrane 4 L6 family member 1 (TM4SF1) OTY0ECQN T4S1_HUMAN Increases Expression [61]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Decreases Expression [61]
P2Y purinoceptor 2 (P2RY2) OT47XN46 P2RY2_HUMAN Decreases Expression [61]
Glycine receptor subunit beta (GLRB) OTF37UG4 GLRB_HUMAN Increases Expression [61]
C-C chemokine receptor type 8 (CCR8) OTSCMH06 CCR8_HUMAN Decreases Expression [61]
Ras-related protein R-Ras2 (RRAS2) OT83NCEB RRAS2_HUMAN Increases Expression [61]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Decreases Expression [61]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [61]
Fascin (FSCN1) OTTGIHTM FSCN1_HUMAN Increases Expression [61]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Increases Expression [61]
Testis-expressed protein 30 (TEX30) OT87WEPQ TEX30_HUMAN Decreases Expression [61]
Ras-related GTP-binding protein A (RRAGA) OTKISLG4 RRAGA_HUMAN Decreases Expression [61]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Increases Expression [61]
RNA-binding protein with multiple splicing (RBPMS) OT1RDKR9 RBPMS_HUMAN Increases Expression [61]
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) OT0CEJOO MS4A3_HUMAN Decreases Expression [61]
Rho GTPase-activating protein 7 (DLC1) OTP8LMCR RHG07_HUMAN Increases Expression [61]
MyoD family inhibitor domain-containing protein (MDFIC) OTSRYBWZ MDFIC_HUMAN Decreases Expression [61]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12) OTOGF42G GBG12_HUMAN Increases Expression [61]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Decreases Expression [61]
PALM2-AKAP2 fusion protein (PALM2AKAP2) OTI618VF PLAK2_HUMAN Increases Expression [61]
Dihydropyrimidinase-related protein 4 (DPYSL4) OT3SBS2S DPYL4_HUMAN Increases Expression [41]
Integral membrane protein GPR137B (GPR137B) OT1CINQQ G137B_HUMAN Increases Expression [41]
Glutaminase kidney isoform, mitochondrial (GLS) OTGOZG2M GLSK_HUMAN Increases Expression [41]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [41]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Increases Expression [41]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [41]
Stomatin (STOM) OTC8R6EH STOM_HUMAN Increases Expression [41]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [41]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Expression [41]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [41]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [41]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [41]
Galectin-7 (LGALS7) OTMSVI7R LEG7_HUMAN Increases Expression [41]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [41]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [41]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [41]
Protein ripply3 (RIPPLY3) OT1HK35I DSCR6_HUMAN Increases Expression [41]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [41]
Antigen peptide transporter 1 (TAP1) OTJL27PW TAP1_HUMAN Increases Expression [41]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [41]
Filamin-C (FLNC) OT3F8J6Y FLNC_HUMAN Increases Expression [41]
Immediate early response gene 5 protein (IER5) OTJPTXMD IER5_HUMAN Increases Expression [41]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [41]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Increases Expression [41]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2) OTOF6O2B B3GL2_HUMAN Increases Expression [41]
Phospholipase ABHD3 (ABHD3) OTH8P977 ABHD3_HUMAN Increases Expression [41]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [41]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Increases Expression [41]
Tumor necrosis factor receptor superfamily member 27 (EDA2R) OTJLAIIH TNR27_HUMAN Increases Expression [41]
Stathmin-3 (STMN3) OT20F289 STMN3_HUMAN Increases Expression [41]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6) OTVUZCLG GTR6_HUMAN Increases Expression [41]
Endothelial protein C receptor (PROCR) OTRHED17 EPCR_HUMAN Increases Expression [41]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [42]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Decreases Expression [42]
Kinesin-like protein KIF21B (KIF21B) OTFXFIU3 KI21B_HUMAN Decreases Expression [42]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Decreases Expression [42]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Decreases Expression [42]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Decreases Expression [42]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [42]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [42]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Decreases Expression [42]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [42]
Protein EVI2A (EVI2A) OTR8RUXQ EVI2A_HUMAN Decreases Expression [42]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [42]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [42]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [42]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Decreases Expression [42]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [42]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Decreases Expression [42]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Decreases Expression [42]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [42]
DNA-binding protein inhibitor ID-2 (ID2) OT0U1D53 ID2_HUMAN Decreases Expression [42]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Decreases Expression [42]
Transmembrane protein 267 (TMEM267) OTEAAVK7 TM267_HUMAN Decreases Expression [42]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [42]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [42]
N-arachidonyl glycine receptor (GPR18) OTL2VFIV GPR18_HUMAN Decreases Expression [42]
Nuclear receptor coactivator 7 (NCOA7) OT2CNBOG NCOA7_HUMAN Decreases Expression [42]
Alanine aminotransferase 2 (GPT2) OTS5VF7N ALAT2_HUMAN Decreases Expression [42]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Increases Expression [42]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [42]
Insulin gene enhancer protein ISL-2 (ISL2) OT43PD2V ISL2_HUMAN Decreases Expression [42]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) OTMLBCLC PELI1_HUMAN Decreases Expression [42]
Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1) OT3SW5UC HYLS1_HUMAN Decreases Expression [42]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [42]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Decreases Expression [42]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Decreases Expression [42]
Protein FAM107B (FAM107B) OT5RG4J0 F107B_HUMAN Decreases Expression [42]
Lysine-rich coiled-coil protein 1 (KRCC1) OTMMV6WZ KRCC1_HUMAN Decreases Expression [42]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Increases Expression [42]
SLAM family member 5 (CD84) OTAY5B0F SLAF5_HUMAN Increases Expression [42]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Decreases Expression [42]
Nuclear factor erythroid 2-related factor 3 (NFE2L3) OT1MGXT0 NF2L3_HUMAN Decreases Expression [42]
Dual specificity protein phosphatase 10 (DUSP10) OTNG467B DUS10_HUMAN Decreases Expression [42]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Decreases Expression [43]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [62]
Growth arrest-specific protein 2 (GAS2) OT50JKXQ GAS2_HUMAN Increases Expression [63]
Lysine-specific histone demethylase 1A (KDM1A) OT85JXS5 KDM1A_HUMAN Increases Expression [64]
Slit homolog 1 protein (SLIT1) OT35RBNT SLIT1_HUMAN Decreases Expression [44]
DnaJ homolog subfamily B member 6 (DNAJB6) OTMHIIAN DNJB6_HUMAN Increases Expression [63]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [65]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Increases Expression [66]
Thymidine kinase, cytosolic (TK1) OTY5JFM1 KITH_HUMAN Increases Mutagenesis [67]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Mutagenesis [68]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Increases Expression [69]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [65]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [70]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [71]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [72]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [73]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [74]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [75]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [69]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [69]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [76]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [43]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [44]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [44]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Methylation [64]
Proteasome subunit alpha type-5 (PSMA5) OT38E6Y1 PSA5_HUMAN Increases Expression [63]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [44]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) OTRAFFX2 GPX4_HUMAN Increases Expression [63]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [74]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [44]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Decreases Expression [76]
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) OT29B58J KCNQ4_HUMAN Decreases Expression [44]
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) OTNPRM8U HNRPK_HUMAN Increases Expression [63]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [43]
Runt-related transcription factor 3 (RUNX3) OTITK1XD RUNX3_HUMAN Decreases Expression [44]
Calicin (CCIN) OTRFZOT0 CALI_HUMAN Increases Expression [63]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [76]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [77]
Partitioning defective 3 homolog (PARD3) OTH5BPLO PARD3_HUMAN Decreases Expression [44]
GATOR1 complex protein NPRL2 (NPRL2) OTOB10MO NPRL2_HUMAN Decreases Expression [44]
F-box/WD repeat-containing protein 7 (FBXW7) OTJXE4OT FBXW7_HUMAN Increases Expression [43]
Rho guanine nucleotide exchange factor 26 (ARHGEF26) OTX0U8PX ARHGQ_HUMAN Increases Expression [44]
G-protein coupled receptor 20 (GPR20) OTPCR8F7 GPR20_HUMAN Increases Expression [44]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [62]
Polyadenylate-binding protein-interacting protein 1 (PAIP1) OTL2F5T5 PAIP1_HUMAN Decreases Expression [44]
Large subunit GTPase 1 homolog (LSG1) OTDAXJ9L LSG1_HUMAN Decreases Expression [44]
Glyoxalase domain-containing protein 4 (GLOD4) OTBJKFXA GLOD4_HUMAN Decreases Expression [44]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Increases Expression [44]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3) OT28VBVK ATG3_HUMAN Decreases Expression [44]
Regulator of telomere elongation helicase 1 (RTEL1) OTI3PJCT RTEL1_HUMAN Increases Expression [63]
FK506-binding protein-like (FKBPL) OTR9ND6K FKBPL_HUMAN Increases Expression [74]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Affects Response To Substance [45]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Affects Response To Substance [45]
Galactocerebrosidase (GALC) OT1F6BZK GALC_HUMAN Affects Response To Substance [45]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Affects Activity [78]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases ADR [40]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Decreases Response To Substance [79]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Affects Response To Substance [45]
Melanoma-associated antigen D1 (MAGED1) OT6EOLFC MAGD1_HUMAN Affects Response To Substance [45]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Affects Response To Substance [45]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Affects Response To Substance [45]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) OT8CMPB2 FKB1B_HUMAN Affects Response To Substance [45]
L-lactate dehydrogenase B chain (LDHB) OT9B1CT3 LDHB_HUMAN Affects Response To Substance [45]
Epsilon-sarcoglycan (SGCE) OT9F17JB SGCE_HUMAN Affects Response To Substance [45]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Response To Substance [80]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Affects Response To Substance [81]
Sterol O-acyltransferase 1 (SOAT1) OTB4Y5RJ SOAT1_HUMAN Affects Response To Substance [45]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) OTB97VIK IF2B3_HUMAN Affects Response To Substance [45]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Affects Response To Substance [45]
Fibronectin type III domain-containing protein 3B (FNDC3B) OTBILGDR FND3B_HUMAN Affects Response To Substance [45]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Affects Response To Substance [45]
Very long chain fatty acid elongase 2 (ELOVL2) OTDAF6U3 ELOV2_HUMAN Affects Response To Substance [45]
Glutathione peroxidase 1 (GPX1) OTE2O72Q GPX1_HUMAN Increases ADR [40]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Decreases Response To Substance [82]
Troponin I, fast skeletal muscle (TNNI2) OTGGZFSC TNNI2_HUMAN Increases ADR [40]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Response To Substance [83]
Tomoregulin-1 (TMEFF1) OTH6M3CH TEFF1_HUMAN Affects Response To Substance [45]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Response To Substance [45]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) OTIOYUSU KS6A2_HUMAN Affects Response To Substance [45]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Affects Response To Substance [84]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Affects Response To Substance [45]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Affects Response To Substance [45]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Affects Response To Substance [45]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Affects Response To Substance [45]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases ADR [40]
Homeobox protein Hox-A1 (HOXA1) OTMSOJ7D HXA1_HUMAN Affects Response To Substance [45]
Trypsin-3 (PRSS3) OTN3S5YB TRY3_HUMAN Affects Response To Substance [45]
Melanoma-associated antigen D4 (MAGED4B) OTO37U7W MAGD4_HUMAN Affects Response To Substance [45]
Opsin-3 (OPN3) OTON6BFU OPN3_HUMAN Affects Response To Substance [45]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Affects Response To Substance [85]
Complement factor I (CFI) OTQYYX0P CFAI_HUMAN Affects Response To Substance [45]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Affects Response To Substance [45]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Response To Substance [86]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Affects Response To Substance [45]
Glycogen debranching enzyme (AGL) OTWBM7WY GDE_HUMAN Affects Response To Substance [45]
Myosin-10 (MYH10) OTXN2WXS MYH10_HUMAN Affects Response To Substance [45]
Sal-like protein 1 (SALL1) OTYYZGLH SALL1_HUMAN Affects Response To Substance [45]
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⏷ Show the Full List of 225 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCGPRW4 OVCAR3 Investigative [1]
Adenocarcinoma DCYQILW HCT116 Investigative [1]
Cutaneous melanoma DCKRR63 SK-MEL-5 Investigative [1]
Melanoma DCG6J7C UACC-257 Investigative [1]
Minimally invasive lung adenocarcinoma DCCBYFQ NCI-H322M Investigative [1]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Dasatinib FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5678).
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
6 Cyclophosphamide FDA Label
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7154).
8 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
9 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
10 The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood. 2008 Aug 15;112(4):1443-52. doi: 10.1182/blood-2007-11-123984. Epub 2008 Jun 12.
11 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
12 Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80.
13 Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64.
14 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
15 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
16 Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
17 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
18 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
19 MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One. 2013 Jun 25;8(6):e66915. doi: 10.1371/journal.pone.0066915. Print 2013.
20 Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. doi: 10.3892/ijo_00000712.
21 Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18.
22 Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
23 Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008 Feb 1;111(3):1366-77. doi: 10.1182/blood-2007-04-084814. Epub 2007 Oct 25.
24 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
25 IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2. Toxicol Appl Pharmacol. 2020 Aug 15;401:115092. doi: 10.1016/j.taap.2020.115092. Epub 2020 Jun 5.
26 Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer. Clin Cancer Res. 2011 Feb 1;17(3):514-24. doi: 10.1158/1078-0432.CCR-10-1617. Epub 2010 Nov 24.
27 High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity. Toxicol Lett. 2018 Oct 15;296:39-47. doi: 10.1016/j.toxlet.2018.08.003. Epub 2018 Aug 4.
28 Dasatinib induces autophagic cell death in human ovarian cancer. Cancer. 2010 Nov 1;116(21):4980-90. doi: 10.1002/cncr.25426.
29 Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res. 2010 Feb 15;16(4):1149-58. doi: 10.1158/1078-0432.CCR-09-2416. Epub 2010 Feb 9.
30 Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol. 2008 Oct;36(10):1244-53. doi: 10.1016/j.exphem.2008.04.017. Epub 2008 Jul 10.
31 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
32 Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Mol Cancer Ther. 2010 Aug;9(8):2322-32. doi: 10.1158/1535-7163.MCT-09-1212. Epub 2010 Aug 3.
33 The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13283-8. doi: 10.1073/pnas.0702654104. Epub 2007 Aug 7.
34 Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. doi: 10.1158/1078-0432.CCR-06-0980.
35 Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett. 2009 Oct 8;283(2):143-51. doi: 10.1016/j.canlet.2009.03.035. Epub 2009 Apr 26.
36 Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. J Biol Chem. 2019 May 31;294(22):8732-8744. doi: 10.1074/jbc.RA119.008360. Epub 2019 Apr 17.
37 Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024. doi: 10.1016/j.bmc.2018.06.027. Epub 2018 Jun 20.
38 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
39 Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.
40 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
41 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
42 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
43 Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
44 Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
45 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
46 O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts. Int J Cancer. 1998 Sep 11;77(6):919-22.
47 Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4). AAPS J. 2010 Sep;12(3):300-8.
48 Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models. Exp Anim. 2018 Feb 9;67(1):71-82.
49 Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66.
50 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
51 Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54.
52 CYP2C9 polymorphisms in human tumors. Anticancer Res. 2006 Jan-Feb;26(1A):299-305.
53 The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metab Dispos. 2002 Jul;30(7):814-22.
54 Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91.
55 Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation. Pharmacogenetics. 1997 Jun;7(3):211-21.
56 Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemother Pharmacol. 2009 Jun;64(1):35-43.
57 Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cellsImpact of prodrug schedule on P450 gene-directed enzyme prodrug therapy. Cancer Gene Ther. 2003 Aug;10(8):571-82.
58 Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology. Toxicol In Vitro. 2001 Jun;15(3):245-56.
59 Qualitative defects of pseudocholinesterase activity. Anaesthesia. 1967 Jan;22(1):55-68.
60 Effect of cyclophosphamide on gene expression of cytochromes p450 and beta-actin in the HL-60 cell line. Eur J Pharmacol. 2002 Aug 9;449(3):197-205.
61 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
62 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
63 Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod. 2007 Aug;77(2):303-11. doi: 10.1095/biolreprod.107.060244. Epub 2007 May 2.
64 Cyclophosphamide perturbs cytosine methylation in Jurkat-T cells through LSD1-mediated stabilization of DNMT1 protein. Chem Res Toxicol. 2011 Nov 21;24(11):2040-3. doi: 10.1021/tx2003849. Epub 2011 Nov 1.
65 PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line. Cancer Chemother Pharmacol. 2010 Sep;66(4):765-71. doi: 10.1007/s00280-009-1221-4. Epub 2009 Dec 30.
66 Suppression of spermatogenesis in patients with Beh?et's disease treated with cyclophosphamide and colchicine. Fertil Steril. 1981 Jul;36(1):76-80. doi: 10.1016/s0015-0282(16)45622-0.
67 Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503129. doi: 10.1016/j.mrgentox.2019.503129. Epub 2019 Dec 27.
68 p53 mutations in cyclophosphamide-associated bladder cancer. Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):397-403.
69 Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
70 Protein assay for heme oxygenase-1 (HO-1) induced by chemicals in HepG2 cells. J Toxicol Sci. 2009 Dec;34(6):709-14. doi: 10.2131/jts.34.709.
71 Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leukemia. 2008 Jan;22(1):179-85. doi: 10.1038/sj.leu.2404959. Epub 2007 Sep 27.
72 Induction of hsp 70 in HepG2 cells in response to hepatotoxicants. Toxicol Appl Pharmacol. 1996 Nov;141(1):117-23.
73 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
74 The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21(WAF-1)) and anti-apoptotic protein (bcl-2) in breast cancer cells. Breast Cancer Res Treat. 2003 Aug;80(3):239-44. doi: 10.1023/A:1024995202135.
75 Distinct Orchestration and Dynamic Processes on -H2AX and p-H3 for Two Major Types of Genotoxic Chemicals Revealed by Mass Spectrometry Analysis. Chem Res Toxicol. 2020 Aug 17;33(8):2108-2119. doi: 10.1021/acs.chemrestox.0c00104. Epub 2020 Jun 17.
76 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
77 Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. Mutat Res. 2011 Sep 18;724(1-2):76-85. doi: 10.1016/j.mrgentox.2011.06.003. Epub 2011 Jun 17.
78 Reduction of plasma fibrinolytic activity following high-dose cyclophosphamide is neutralized in vivo by GM-CSF administration. Haematologica. 1993 Mar-Apr;78(2):105-10.
79 Inhibition of glutathione synthesis reverses Krppel-like factor 4-mediated cisplatin resistance. Cancer Chemother Pharmacol. 2012 Feb;69(2):377-85. doi: 10.1007/s00280-011-1708-7. Epub 2011 Jul 22.
80 Important role of caspase-8 for chemosensitivity of ALL cells. Clin Cancer Res. 2011 Dec 15;17(24):7605-13. doi: 10.1158/1078-0432.CCR-11-0513. Epub 2011 Oct 18.
81 Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenet Genomics. 2008 Nov;18(11):1009-15. doi: 10.1097/FPC.0b013e328313aaa4.
82 The evaluation of Cannabidiol's effect on the immunotherapy of Burkitt lymphoma. Biochem Biophys Res Commun. 2019 Nov 26;520(1):225-230. doi: 10.1016/j.bbrc.2019.10.001. Epub 2019 Oct 3.
83 [Establishment of MRP-overexpression subline of bladder carcinoma and its MDR phenotype]. Zhonghua Zhong Liu Za Zhi. 2000 Jul;22(4):273-5.
84 Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Breast Cancer Res Treat. 2010 Nov;124(2):433-9. doi: 10.1007/s10549-010-0840-0. Epub 2010 Mar 23.
85 T-889C IL-1alpha promoter polymorphism influences the response to oral cyclophosphamide in scleroderma patients with alveolitis. Clin Rheumatol. 2007 Jan;26(1):88-91. doi: 10.1007/s10067-006-0308-0. Epub 2006 Apr 25.
86 Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer. J Clin Oncol. 2005 Sep 1;23(25):6117-25. doi: 10.1200/JCO.2005.06.075. Epub 2005 Aug 8.