General Information of Drug (ID: DM17ONX)

Drug Name
Fexofenadine Drug Info
Synonyms
Carboxyterfenadine; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; F 9427; MDL 16455; Allegra (TN); Fastofen (TN); Fexofenadine (INN); Fexofenadine [INN:BAN]; Telfast (TN); Terfenadine-COOH; Terfenidine carboxylate, MDL 16455; Tilfur (TN); 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
Indication
Disease Entry ICD 11 Status REF
Allergic rhinitis CA08.0 Approved [1]
Seasonal allergic rhinitis CA08.01 Approved [2]
Therapeutic Class
Antiallergic Agents
Cross-matching ID
PubChem CID
3348
ChEBI ID
CHEBI:5050
CAS Number
CAS 83799-24-0
TTD Drug ID
DM17ONX
VARIDT Drug ID
DR00026
ACDINA Drug ID
D00273

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [14]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [15]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [16]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [17]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [16]
Doxepin DMPI98T Anxiety Approved [18]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [16]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [19]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [20]
Tranilast DME5Y64 Allergic rhinitis CA08.0 Approved [21]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Folic Acid DMEMBJC Colorectal carcinoma Approved [25]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [24]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [34]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [35]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [36]
Propranolol DM79NTF Angina pectoris BA40 Approved [37]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Folic Acid DMEMBJC Colorectal carcinoma Approved [39]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [42]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [43]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [44]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [45]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [46]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [47]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [49]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [50]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [7]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [51]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [52]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [53]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [54]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [55]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [56]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [58]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [60]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [58]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [61]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [62]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [63]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [64]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [63]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [65]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [66]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [67]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [68]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [69]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [70]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [71]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [72]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [73]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [74]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [77]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [78]
Cepharanthine DM9Y5JB N. A. N. A. Approved [79]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [80]
Clozapine DMFC71L Schizophrenia 6A20 Approved [81]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [82]
Trifluoperazine DMKBYWI Anxiety Approved [83]
Olanzapine DMPFN6Y Bipolar depression Approved [81]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [84]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [85]
Trospium chloride DM32XZT Discovery agent N.A. Approved [86]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [88]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [89]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
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Drug(s) Affected By C-C motif chemokine 22 (CCL22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [96]
Arsenic DMTL2Y1 N. A. N. A. Approved [97]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [98]
MLN4924 DMP36KD Myelodysplastic syndrome 2A37 Phase 3 [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [101]
Milchsaure DM462BT Pruritus EC90 Investigative [102]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [10]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [10]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [10]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [10]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [10]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [119]
Selenium DM25CGV N. A. N. A. Approved [120]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [121]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [122]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [123]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [10]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [10]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [10]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [10]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [10]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [124]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [124]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [126]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [129]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [123]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [130]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [132]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [133]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [134]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [10]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [136]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [137]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [138]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [139]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [140]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [141]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [142]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [143]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [144]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [147]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [149]
Gefitinib DM15F0X Colon adenocarcinoma Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [152]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [153]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [144]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [154]
Paclitaxel DMLB81S Breast carcinoma Approved [155]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [156]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [143]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [147]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [157]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [158]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [159]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [161]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [162]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [166]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [167]
Quinidine DMLPICK N. A. N. A. Approved [168]
Verapamil DMA7PEW Angina pectoris BA40 Approved [169]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [170]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [170]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [171]
Propranolol DM79NTF Angina pectoris BA40 Approved [172]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [173]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [174]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [170]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [10]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [10]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [10]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [10]
Amikacin DM5PDRB Bacteremia 1A73 Approved [10]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [10]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [10]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [175]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [10]
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Drug(s) Affected By C-C motif chemokine 17 (CCL17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [176]
Isoproterenol DMK7MEY Atrioventricular block Approved [177]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [96]
MLN4924 DMP36KD Myelodysplastic syndrome 2A37 Phase 3 [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [101]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [179]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [10]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [10]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [180]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Fluoxetine DM3PD2C Bipolar depression Approved [181]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [183]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [184]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [185]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [186]
Methotrexate DM2TEOL Anterior urethra cancer Approved [187]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [188]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [189]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [189]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [85]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [190]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [4]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [5]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [6]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [10]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [11]
C-C motif chemokine 17 (CCL17) OTIKW21L CCL17_HUMAN Gene/Protein Processing [12]
C-C motif chemokine 22 (CCL22) OTT3QJC2 CCL22_HUMAN Gene/Protein Processing [12]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [10]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [10]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [13]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Gene/Protein Processing [10]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [10]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [10]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4819).
2 Fexofenadine FDA Label
3 Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8.
4 Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
5 Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther. 2007 Mar;81(3):362-70.
6 The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. Pharmacogenet Genomics. 2011 Feb;21(2):84-93.
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