Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2L6OZ)

• Drug Name: 27-hydroxycholesterol Drug Info
• Synonyms: 27-OHC; 26-hydroxycholesterol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 123976
  ChEBI ID: CHEMBL353882
  CAS Number: CAS 20380-11-4
  TTD Drug ID: DM2L6OZ

Molecule-Related Drug Atlas

Drug(s) Targeting Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTB-38543	DMNY3J0	Atopic dermatitis	EA80	Phase 2	[11]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[12]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[13]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[14]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[15]
22R-hydroxycholesterol	DME8273	Discovery agent	N.A.	Investigative	[16]
GSK-9772	DM4WS3R	Discovery agent	N.A.	Investigative	[17]
Riccardin C	DM6MYGX	Discovery agent	N.A.	Investigative	[18]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione	DMH76SO	Discovery agent	N.A.	Investigative	[19]
AZ12260493	DMQ5H2V	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[21]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[22]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[23]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[21]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[23]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[22]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[23]
67S	DMJL1MB	N. A.	N. A.	Patented	[22]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[21]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting EBV-induced G-protein coupled receptor 2 (GPR183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
25-hydroxycholesterol	DMCHAQ7	Discovery agent	N.A.	Investigative	[2]
7alpha,25-dihydroxycholesterol	DM2N8TW	Discovery agent	N.A.	Investigative	[24]
7alpha,27-dihydroxycholesterol	DM52UOM	Discovery agent	N.A.	Investigative	[2]
7beta-hydroxycholesterol	DMPHJZU	Discovery agent	N.A.	Investigative	[2]
7beta, 27-dihydroxycholesterol	DMSDINR	Discovery agent	N.A.	Investigative	[2]
7alpha-hydroxycholesterol	DMH6LD0	Discovery agent	N.A.	Investigative	[2]
7beta, 25-dihydroxycholesterol	DMYKXWE	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[25]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[33]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[31]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[38]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[39]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[45]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[48]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[49]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[50]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[54]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[67]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[77]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[78]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[79]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[80]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[81]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[82]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[84]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[85]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[86]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[84]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[92]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[92]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[34]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[92]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[97]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[99]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[105]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[99]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[109]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[110]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[101]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[119]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[121]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[123]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[132]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[137]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[139]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[146]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[147]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[150]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[156]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[157]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[158]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[165]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[165]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[175]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[182]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[185]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[149]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[190]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[192]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[195]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[196]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
EBV-induced G-protein coupled receptor 2 (GPR183)	TTME5YJ	GP183_HUMAN	Agonist	[2]
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Agonist	[3]
Oxysterols receptor LXR-beta (NR1H2)	TTXA6PH	NR1H2_HUMAN	Agonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[4]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[5]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[6]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[7]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[9]
Cadherin-5 (CDH5)	OTVX0E1Q	CADH5_HUMAN	Gene/Protein Processing	[4]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[4]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Gene/Protein Processing	[10]

References

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