General Information of Drug (ID: DM3BH1Y)

Drug Name
Lapatinib Drug Info
Synonyms
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Gastroesophageal junction adenocarcinoma 2B71 Approved [2]
Melanoma 2C30 Approved [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
208908
ChEBI ID
CHEMBL554
CAS Number
CAS 231277-92-2
TTD Drug ID
DM3BH1Y
VARIDT Drug ID
DR00120
INTEDE Drug ID
DR0917
ACDINA Drug ID
D00351

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [16]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [17]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [18]
NERATINIB MALEATE DMEDU7B HER2/NEU overexpressing breast cancer 2C60-2C65 Approved [19]
Margetuximab DMKEY6S HER2-positive breast cancer 2C60-2C65 Approved [20]
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [21]
Tucatinib DMBESUA HER2-positive breast cancer 2C60-2C65 Approved [22]
Pertuzumab DMHJV0X Adrenal gland neoplasm Approved [23]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [24]
HKI-272 DM6QOVN Breast cancer 2C60-2C65 Phase 3 [25]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [26]
Gefitinib DM15F0X Colon adenocarcinoma Approved [27]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [28]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [25]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [29]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [17]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [30]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [29]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [18]
Nitroglycerin DMQ2491 Angina pectoris BA40 Approved [31]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [35]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [37]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Folic Acid DMEMBJC Colorectal carcinoma Approved [41]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [46]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [47]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [56]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [57]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [58]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [62]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [60]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [67]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [68]
Verapamil DMA7PEW Angina pectoris BA40 Approved [69]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [70]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [71]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [67]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [72]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [73]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [74]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [75]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [76]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [68]
Verapamil DMA7PEW Angina pectoris BA40 Approved [78]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [81]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [73]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [10]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [82]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [82]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [83]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [10]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [82]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [15]
Gefitinib DM15F0X Colon adenocarcinoma Approved [10]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [84]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [10]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Selenium DM25CGV N. A. N. A. Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Epinephrine DM3KJBC Acute asthma CA23 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [90]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [87]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [94]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Etretinate DM2CZFA Keratosis ED56 Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [107]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [113]
Selenium DM25CGV N. A. N. A. Approved [114]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [115]
Etretinate DM2CZFA Keratosis ED56 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [122]
Verapamil DMA7PEW Angina pectoris BA40 Approved [123]
Methysergide DM1EF73 Migraine 8A80 Approved [15]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [127]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Panobinostat DM58WKG Chronic graft versus host disease Approved [131]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [135]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [136]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [137]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [138]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [140]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [142]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [143]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [144]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [145]
Gefitinib DM15F0X Colon adenocarcinoma Approved [146]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [147]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [148]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [149]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [140]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [150]
Paclitaxel DMLB81S Breast carcinoma Approved [151]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [152]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [153]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [154]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [142]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [143]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Gefitinib DM15F0X Colon adenocarcinoma Approved [156]
Prednisone DM2HG4X Acute asthma CA23 Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [160]
Fluoxetine DM3PD2C Bipolar depression Approved [161]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [162]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [164]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [165]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [166]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [132]
Testosterone enanthate DMB6871 N. A. N. A. Approved [167]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [168]
Arsenic DMTL2Y1 N. A. N. A. Approved [169]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [165]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [172]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [173]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [174]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [178]
Leflunomide DMR8ONJ Arthritis FA20 Approved [179]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [180]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [181]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [182]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [153]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [184]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [185]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [186]
Prednisone DM2HG4X Acute asthma CA23 Approved [187]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [188]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
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Drug(s) Affected By Tenascin-X (TNXB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [191]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [193]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [138]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [194]
Arsenic DMTL2Y1 N. A. N. A. Approved [195]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [196]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [197]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [198]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [199]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [200]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [200]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Allopurinol DMLPAOB Gout FA25 Approved [201]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [202]
Selenium DM25CGV N. A. N. A. Approved [114]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [3]
Erbb2 tyrosine kinase receptor (HER2) TT6EO5L ERBB2_HUMAN Inhibitor [3]
Eukaryotic elongation factor 2 kinase (eEF-2K) TT1QFLA EF2K_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [7]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [8]
Cytochrome P450 3A5 (CYP3A5) Main DME DEIBDNY CP3A5_HUMAN Substrate [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [9]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [10]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [11]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [12]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Drug Response [13]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Drug Response [13]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [14]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [14]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Gene/Protein Processing [15]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [14]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5692).
2 Lapatinib FDA Label
3 Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
4 Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways.BMC Cancer. 2016 Oct 19;16(1):813.
5 The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metab Dispos. 2008 Apr;36(4):695-701.
6 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
7 Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Mol Pharmacol. 2010 Oct;78(4):693-703.
8 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
9 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
10 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
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