General Information of Drug (ID: DM4XAU7)

Drug Name
PGF2alpha Drug Info
Synonyms Amoglandin; Cerviprost; Cyclosin; Enzaprost; Panacelan; prostaglandin F2alpha
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Clinical trial [1]
Cross-matching ID
PubChem CID
5280363
ChEBI ID
CHEBI:15553
CAS Number
CAS 551-11-1
TTD Drug ID
DM4XAU7
VARIDT Drug ID
DR00007
INTEDE Drug ID
DR1917

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AS-013 DMD7XWS Thrombosis DB61-GB90 Phase 3 [22]
BUTAPROST DMVYNJZ Discovery agent N.A. Patented [23]
ZD6416 DM46JIR Pain MG30-MG3Z Discontinued in Phase 2 [24]
ONO-8130 DMBDCL4 Pollakiuria MF50.1 Terminated [25]
ONO-8711 DM2VRK7 Pain MG30-MG3Z Terminated [26]
U46619 DM13FX4 Discovery agent N.A. Investigative [4]
carbacyclin DMMBQYE Discovery agent N.A. Investigative [2]
PGD2 DMYDW6J Discovery agent N.A. Investigative [27]
M&B 28767 DMJQG82 Discovery agent N.A. Investigative [6]
cicaprost DM7ZJ4H Discovery agent N.A. Investigative [2]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
16,16-dimethyl-PGE2 DMNF38S Stem cell engraftment QB63.8 Phase 2 [6]
RQ-00000007 (oral) DMMYTRU Pain MG30-MG3Z Phase 2 [28]
ONO-AE1-437 DMCUGI8 Asthma CA23 Phase 2 [29]
BGC-20-1531 DMS2MQ5 Migraine 8A80 Phase 2 [30]
IK-007 DMBLFPN Non-small-cell lung cancer 2C25 Phase 1/2 [31]
TPST-1495 DM3GSB2 Solid tumour/cancer 2A00-2F9Z Phase 1 [32]
E7046 DMFVT43 Rectal adenocarcinoma 2B92 Phase 1 [33]
ONO-4232 DMO4SD2 Acute heart failure BD10-BD13 Phase 1 [34]
ONO-4578 DME63VK Solid tumour/cancer 2A00-2F9Z Phase 1 [33]
AN0025 DMGSYPY Aggressive cancer 2A00-2F9Z Phase 1 [35]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [23]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [36]
Alprostadil DMWH7NQ Aorta coarctation Approved [37]
Iloprost DMVPZBE Pulmonary arterial hypertension BB01.0 Approved [38]
Omidenepag isopropyl DMUX7Z8 Glaucoma/ocular hypertension 9C61 Approved [39]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [40]
16,16-dimethyl-PGE2 DMNF38S Stem cell engraftment QB63.8 Phase 2 [6]
CP-533536 DMZEJLB Osteoporosis FB83.0 Phase 2 [41]
Taprenepag DM1TSHL Glaucoma/ocular hypertension 9C61 Phase 2 [42]
TPST-1495 DM3GSB2 Solid tumour/cancer 2A00-2F9Z Phase 1 [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [40]
Setipiprant DMZ61IA Asthma CA23 Phase 3 [43]
Fevipiprant DM4NX0C Asthma CA23 Phase 3 [44]
Ramatroban DMB8UQ3 Perennial allergic rhinitis CA08.03 Phase 2/3 [45]
AMG 853 DM973N4 Asthma CA23 Phase 2 [46]
ADC-3680 DM8GHIX Allergic rhinitis CA08.0 Phase 2 [47]
ARRY-502 DM17469 Allergic asthma CA23.0 Phase 2 [48]
QAV-680 DMIZYV1 Allergic rhinitis CA08.0 Phase 2 [49]
AP-761 DMISQOZ Asthma CA23 Phase 2 [50]
AZD1981 DMMCL9F Chronic obstructive pulmonary disease CA22 Phase 2 [51]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [40]
Setipiprant DMZ61IA Asthma CA23 Phase 3 [52]
QAW-039 DMPCFXN Asthma CA23 Phase 3 [53]
AMG 853 DM973N4 Asthma CA23 Phase 2 [46]
ONO-4053 DMX4MVP Allergic rhinitis CA08.0 Phase 2 [54]
TS-022 DMMNXIW Atopic dermatitis EA80 Phase 2 [55]
S-555739 DMXDVNZ Allergy 4A80-4A85 Phase 2 [56]
MK-1029 DM8ZTW7 Asthma CA23 Phase 2 [47]
SAR-389644 DMA6O9R Allergic rhinitis CA08.0 Phase 1 [57]
192C86 DMQ8NTZ Thrombosis DB61-GB90 Phase 1 [58]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [23]
Latanoprost DMI5OXG Ocular hypertension 9C61.01 Approved [59]
BOL-303259-X DM2EXC5 Open-angle glaucoma 9C61 Approved [60]
Tafluprost DMFC41K Glaucoma/ocular hypertension 9C61 Approved [61]
Carboprost Tromethamine DMS3508 Abortion JA00 Approved [62]
Travoprost DM20K91 Ocular hypertension 9C61.01 Approved [63]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [40]
PGF2ALPHA-IE DM5DAP3 Glaucoma/ocular hypertension 9C61 Phase 3 [64]
ONO-9054 DM5O6GC Glaucoma/ocular hypertension 9C61 Phase 2 [65]
PDC-41 DM74YO8 Dysmenorrhea GA34.3 Phase 1 [66]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Alprostadil DMWH7NQ Aorta coarctation Approved [67]
Ridogrel DMWH9CN Acute myocardial infarction BA41 Approved [68]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [40]
Ramatroban DMB8UQ3 Perennial allergic rhinitis CA08.03 Phase 2/3 [69]
KP-496 DMCO8UZ Asthma CA23 Phase 2 [70]
FK-070 DMJSD5W Angina pectoris BA40 Phase 2 [71]
TAK-128 DMHPEFS Diabetic neuropathy 8C0Z Phase 2 [72]
Ifetroban sodium DMZP84Y Thrombosis DB61-GB90 Phase 2 [73]
Ifetroban DMEV39E Aspirin-induced asthma CA23.20 Phase 2 [74]
YM-57158 DMS31YW Allergic rhinitis CA08.0 Phase 1 [75]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
16,16-dimethyl-PGE2 DMNF38S Stem cell engraftment QB63.8 Phase 2 [6]
ONO-9054 DM5O6GC Glaucoma/ocular hypertension 9C61 Phase 2 [65]
BUTAPROST DMVYNJZ Discovery agent N.A. Patented [23]
DG041 DMVO9WM Peripheral vascular disease BD4Z Discontinued in Phase 2 [76]
GR-63799X DM13GK8 Asthma CA23 Discontinued in Phase 1 [77]
U46619 DM13FX4 Discovery agent N.A. Investigative [2]
carbacyclin DMMBQYE Discovery agent N.A. Investigative [6]
PGD2 DMYDW6J Discovery agent N.A. Investigative [4]
butaprost (free acid form) DM5MZHP Discovery agent N.A. Investigative [2]
M&B 28767 DMJQG82 Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [79]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [82]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [83]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [84]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [85]
Theophylline DMRJFN9 Bronchitis CA20 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [87]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [88]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [89]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [90]
Propranolol DM79NTF Angina pectoris BA40 Approved [91]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [92]
Metformin DM89QE1 Colorectal carcinoma Approved [93]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [91]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [86]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [95]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [96]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [97]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [98]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [99]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [100]
Propranolol DM79NTF Angina pectoris BA40 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Folic Acid DMEMBJC Colorectal carcinoma Approved [102]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [103]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [104]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [12]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [105]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [106]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [107]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [108]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [12]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [80]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [80]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [111]
Olmesartan medoxomil DMWBHRY High blood pressure BA00 Approved [112]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [113]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [114]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [116]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [117]
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [118]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [119]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [120]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [121]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [11]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [124]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [80]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [125]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [126]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [127]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [128]
Levocetirizine DMQYLGP Allergic rhinitis CA08.0 Approved [129]
uric acid DMA1MKT Discovery agent N.A. Investigative [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [131]
Alprostadil DMWH7NQ Aorta coarctation Approved [8]
Iloprost DMVPZBE Pulmonary arterial hypertension BB01.0 Approved [8]
Latanoprost DMI5OXG Ocular hypertension 9C61.01 Approved [132]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [9]
Alprostadil DMWH7NQ Aorta coarctation Approved [9]
Iloprost DMVPZBE Pulmonary arterial hypertension BB01.0 Approved [9]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [131]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [131]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [133]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [134]
FENOFIBRIC ACID DMGO2MC Cardiovascular disease BA00-BE2Z Approved [135]
VUFB-11502 DM7WFR0 N. A. N. A. Preclinical [136]
Phenanthrene-9,10-dione DMG8KS9 Discovery agent N.A. Investigative [137]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [138]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [139]
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [141]
Paclitaxel DMLB81S Breast carcinoma Approved [79]
Allopurinol DMLPAOB Gout FA25 Approved [79]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [79]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [79]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [79]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [79]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [143]
Testosterone DM7HUNW Hot flushes GA30 Approved [144]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [146]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [147]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [148]
Ethanol DMDRQZU Chronic pain MG30 Approved [149]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [150]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [151]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Verapamil DMA7PEW Angina pectoris BA40 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [154]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [161]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [162]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Arsenic DMTL2Y1 N. A. N. A. Approved [164]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [166]
PGD2 DMYDW6J Discovery agent N.A. Investigative [15]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [167]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [168]
Gefitinib DM15F0X Colon adenocarcinoma Approved [169]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [171]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [170]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [172]
Selenium DM25CGV N. A. N. A. Approved [173]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [174]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [175]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [176]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [177]
Fructose DM43AN2 Vomiting MD90 Approved [151]
Ketoprofen DMRKXPT Bursitis Approved [151]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [179]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [180]
Gefitinib DM15F0X Colon adenocarcinoma Approved [181]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [184]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [185]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [186]
Selenium DM25CGV N. A. N. A. Approved [160]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [189]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [190]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
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Drug(s) Affected By Cocaine esterase (CES2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [190]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [193]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [186]
Methotrexate DM2TEOL Anterior urethra cancer Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [194]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [195]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [196]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [197]
Testosterone enanthate DMB6871 N. A. N. A. Approved [198]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [200]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [202]
Methotrexate DM2TEOL Anterior urethra cancer Approved [203]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [204]
Quercetin DM3NC4M Obesity 5B81 Approved [205]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [207]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [208]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [160]
Methotrexate DM2TEOL Anterior urethra cancer Approved [210]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [211]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [212]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [213]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [214]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [214]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [216]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [217]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [218]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [202]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [219]
Prednisone DM2HG4X Acute asthma CA23 Approved [220]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [221]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [223]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [225]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [170]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [170]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [170]
Methotrexate DM2TEOL Anterior urethra cancer Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [226]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [170]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [228]
Diazepam DM08E9O Alcohol withdrawal Approved [229]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [230]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [231]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [194]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [228]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [233]
Testosterone DM7HUNW Hot flushes GA30 Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [235]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [212]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [237]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [238]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [239]
Testosterone DM7HUNW Hot flushes GA30 Approved [240]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin D2 receptor (PTGDR) TTNVEIR PD2R_HUMAN Agonist [2]
Prostaglandin D2 receptor 2 (PTGDR2) TTQDMX5 PD2R2_HUMAN Agonist [3]
Prostaglandin E2 receptor EP1 (PTGER1) TTG1QMU PE2R1_HUMAN Agonist [4]
Prostaglandin E2 receptor EP2 (PTGER2) TT1ZAVI PE2R2_HUMAN Agonist [5]
Prostaglandin E2 receptor EP3 (PTGER3) TTPNGDE PE2R3_HUMAN Agonist [6]
Prostaglandin E2 receptor EP4 (PTGER4) TT79WV3 PE2R4_HUMAN Agonist [4]
Prostaglandin F2-alpha receptor (PTGFR) TTT2ZAR PF2R_HUMAN Agonist [7]
Thromboxane A2 receptor (TBXA2R) TT2O84V TA2R_HUMAN Agonist [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 2A1 (SLCO2A1) DT021JD SO2A1_HUMAN Substrate [8]
Organic anion transporting polypeptide 3A1 (SLCO3A1) DTVNRXW SO3A1_HUMAN Substrate [9]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [10]
Organic anion transporter 4 (SLC22A11) DT06JWZ S22AB_HUMAN Substrate [11]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [12]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [11]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [11]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [11]
Organic anion transporter 3 (SLC22A8) DTVP67E S22A8_HUMAN Substrate [11]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
NADPH-dependent carbonyl reductase 1 (CBR1) Main DME DE9JFMC CBR1_HUMAN Substrate [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [14]
Acyl-protein thioesterase 2 (LYPLA2) OT03UIYC LYPA2_HUMAN Biotransformations [15]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Regulation of Drug Effects [16]
Choriogonadotropin subunit beta 3 (CGB3) OTVM2SU3 CGB3_HUMAN Biotransformations [17]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Biotransformations [18]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Regulation of Drug Effects [19]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Regulation of Drug Effects [20]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Regulation of Drug Effects [20]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Regulation of Drug Effects [21]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Biotransformations [18]

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126 Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
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136 The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab Rev. 2016 May;48(2):159-82.
137 Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103.
138 Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48.
139 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
140 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
141 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
142 SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
143 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
144 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
145 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
146 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
147 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
148 Inhibition of 11-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochem Pharmacol. 2017 Apr 15;130:93-103. doi: 10.1016/j.bcp.2017.01.010. Epub 2017 Jan 25.
149 cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
150 The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61.
151 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
152 Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
153 Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
154 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
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