General Information of Drug (ID: DM5PCS7)

Drug Name
Bupropion Drug Info
Synonyms
bupropion; Amfebutamone; 34911-55-2; Amfebutamon; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; amfebutamonum; Amfebutamona; (+-)-Bupropion; Wellbatrin; Bupropion [INN:BAN]; 34841-39-9; Elontril; Amfebutamonum [INN-Latin]; Zyban; Amfebutamona [INN-Spanish]; Bupropion SR; AMFEBUTAMONE HCl; alpha-(tert-butylamino)-m-chloropropiophenone; CHEMBL894; BRN 2101062; (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone; CHEBI:3219; SNPPWIUOZRMYNY-UHFFFAOYSA-N; 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one; Amfebutamon; Amfebutamonum; Elont; Bupropion Hcl; Bupropion hydrocloride; Bupropion (INN); Bupropion (Old RN); Bupropion (USAN); Alpha-(tert-Butylamino)-m-chloropropiophenone; Alpha-(tert-butylamino)-m-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chloropropiophenone; (-)-2-(tert-Butylamino)-3'-chlorpropiophenon; 1-Propanone; 2-(Tert-Butylamino)-3'-chloropropiophenone
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Lung cancer 2C25.0 Approved [1]
Major depressive disorder 6A70.3 Approved [1]
Obesity 5B81 Approved [1]
Seasonal affective disorder Approved [1]
Smoking dependence 6C4A.2 Approved [2]
Cross-matching ID
PubChem CID
444
ChEBI ID
CHEBI:3219
CAS Number
CAS 34911-55-2
TTD Drug ID
DM5PCS7
VARIDT Drug ID
DR00836
INTEDE Drug ID
DR0247
ACDINA Drug ID
D00083

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [17]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [15]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [18]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [19]
Venlafaxine DMR6QH0 Anxiety disorder 6B00-6B0Z Approved [3]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [20]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [21]
Levomilnacipran DMV26S8 Fibromyalgia MG30.01 Approved [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [16]
Fluoxetine DM3PD2C Bipolar depression Approved [23]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [18]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [23]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [23]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [23]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [23]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [26]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [30]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [35]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [47]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [48]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [49]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [50]
Propranolol DM79NTF Angina pectoris BA40 Approved [51]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [57]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Estrone DM5T6US Acne vulgaris ED80 Approved [59]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [60]
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [66]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [67]
Estrone DM5T6US Acne vulgaris ED80 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [69]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [71]
Estrone DM5T6US Acne vulgaris ED80 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [73]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [74]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [75]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [76]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [79]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [80]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [81]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [82]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [83]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [84]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [85]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [86]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [87]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [94]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [97]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [98]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [14]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [100]
Fluoxetine DM3PD2C Bipolar depression Approved [14]
Fructose DM43AN2 Vomiting MD90 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [105]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [109]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [110]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [122]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [123]
Allopurinol DMLPAOB Gout FA25 Approved [124]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [125]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [126]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [127]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [13]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [128]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [131]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [132]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [133]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [134]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [136]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [137]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [138]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [139]
Etretinate DM2CZFA Keratosis ED56 Approved [140]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [141]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [146]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [147]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [149]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [152]
Meloxicam DM2AR7L Arthritis FA20 Approved [153]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [154]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [14]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Fluoxetine DM3PD2C Bipolar depression Approved [14]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [160]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [162]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [163]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [164]
Testosterone DM7HUNW Hot flushes GA30 Approved [165]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [167]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [168]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [169]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [170]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [171]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [172]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [173]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [174]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [152]
Selenium DM25CGV N. A. N. A. Approved [112]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [154]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [176]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [13]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [178]
Fluoxetine DM3PD2C Bipolar depression Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [180]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [181]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Aripiprazole DM3NUMH Bipolar I disorder Approved [183]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
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Drug(s) Affected By D(2) dopamine receptor (DRD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Droperidol DM0DXA8 Nausea MD90 Approved [184]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [184]
Zuclopenthixol DMKYD5N Schizophrenia 6A20 Approved [184]
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [185]
Sulpiride DMF54ZG Schizophrenia 6A20 Approved [186]
Risperidone DMN6DXL Bipolar I disorder Approved [187]
Olanzapine DMPFN6Y Bipolar depression Approved [188]
Methamphetamine DMPM4SK Anxiety Approved [189]
Bromocriptine DMVE3TK Acromegaly 5A60.0 Approved [190]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [194]
Artemether DM48QOT Malaria 1F40-1F45 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [196]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [197]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [198]
Estrone DM5T6US Acne vulgaris ED80 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [201]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [119]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [203]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [204]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [3]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [7]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [8]
Cytochrome P450 2B6 (CYP2B6) Main DME DEPKLMQ CP2B6_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [10]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [10]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Biotransformations [11]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Drug Response [12]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [10]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Post-Translational Modifications [10]
HLA class I histocompatibility antigen, A alpha chain (HLA-A) OTAH14LU HLAA_HUMAN Gene/Protein Processing [13]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Gene/Protein Processing [13]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Gene/Protein Processing [14]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [13]

References

1 Bupropion FDA Label
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