Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM62UG5)

Drug Name
Vemurafenib Drug Info
Synonyms PLX4032; RG7204; RO5185426; Zelboraf (TN); Vemurafenib (BRAF inhibitor)
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Cross-matching ID
PubChem CID
42611257
ChEBI ID
CHEMBL63637
CAS Number
CAS 918504-65-1
TTD Drug ID
DM62UG5
VARIDT Drug ID
DR00711
INTEDE Drug ID
DR1677
ACDINA Drug ID
D00723

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serine/threonine-protein kinase B-raf (BRAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [11]
LGX818 DMNQXV8 Melanoma 2C30 Approved [12]
PLX8394 DMRTD7I Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
CEP-32496 DMAO04B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [14]
BGB-283 DMVYTG7 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [15]
ARQ 736 DMP9ZT1 Solid tumour/cancer 2A00-2F9Z Phase 1 [16]
RO-5212054 DML4C3Q Solid tumour/cancer 2A00-2F9Z Phase 1 [17]
ASN003 DMJCX6D Solid tumour/cancer 2A00-2F9Z Phase 1 [18]
BMS-908662 DM3K8VM Solid tumour/cancer 2A00-2F9Z Phase 1 [19]
ABM-1310 DMS1HR3 Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [21]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [3]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [30]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [3]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [31]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [32]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [33]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [34]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [31]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [3]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [3]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [38]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [32]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [39]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [47]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [64]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [65]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [73]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [74]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [82]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [83]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [87]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [88]
Paclitaxel DMLB81S Breast carcinoma Approved [89]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [78]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD70 antigen (CD70)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Menthol DMG2KW7 Back pain ME84.Z Approved [97]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [98]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [99]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanocyte protein PMEL (PMEL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [106]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [107]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [108]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [109]
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Drug(s) Affected By Melanoma antigen recognized by T-cells 1 (MLANA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [110]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [108]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [111]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [93]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [3]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [3]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5,6-dihydroxyindole-2-carboxylic acid oxidase OTRK49R4 TYRP1_HUMAN Gene/Protein Processing [6]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [7]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Gene/Protein Processing [8]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Gene/Protein Processing [6]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Gene/Protein Processing [6]
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Gene/Protein Processing [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [9]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [9]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [10]
Transcriptional coactivator YAP1 OTS78EC3 YAP1_HUMAN Drug Response [9]

References

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50 The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
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63 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
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65 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
66 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
67 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
68 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
69 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
70 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
71 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
72 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
73 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
74 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
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