General Information of Drug (ID: DM79NTF)

Drug Name
Propranolol Drug Info
Synonyms
Anaprilin; Anapriline; Avlocardyl; Bedranol; Berkolol; Betachron; Betadren; Betalong; Caridolol; Corpendol; Dociton; Efektolol; Etalong; Euprovasin; Herzbase; Ikopal; Inderal; Inderalici; Inderex; Inderol; Intermigran; Kemi; Migrastat; Naprilin; Obsidan; Obzidan; Pranolol; Pronovan; Propanalol; Propanix; Propanolol; Propranalol; Propranololo; Propranololum; Proprasylyt; Reducor; Sawatal; Servanolol; Sumial; Beta Neg; Inderal hydrochloride; Kemi S; Propranolol Hcl Intensol; Propranololo [DCIT]; Racemic propranolol; Reducorline; AY 64043; AY-20694; Anaprilinum (TN); Avlocardyl (TN); Beta-Propranolol; Beta-Tablinen; Beta-Timelets; DL-Propranolol hydrochloride; Deralin (TN); Dociton (TN); Inderal (TN); Inderal LA (TN); Inderalici (TN); InnoPran XL (TN); Propanolol [INN-Spanish]; Propranolol (INN); Propranolol (TN); Propranolol [INN:BAN]; Propranololum [INN-Latin]; Sumial (TN); D,L-Propranolol; INDERIDE-40/25; R,S-Propranolol Hydrochloride; (+-)-Propranolol; (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol; (R)-(+)-propranolol; (S)-(-)-PROPRANOLOL; 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol; 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane; 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol; 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol; 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol; 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol; 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol; 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol; 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-(9CI); 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)-(9CI); 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
Atrial fibrillation BC81.3 Approved [1]
Cocaine addiction 6C45.2 Approved [1]
Hemangioma 2E81-2F2Y Approved [1]
Migraine 8A80 Approved [2]
Respiratory papillomatosis 2F00.1 Investigative [1]
Therapeutic Class
Antianxiety Agents
Cross-matching ID
PubChem CID
4946
ChEBI ID
CHEBI:8499
CAS Number
CAS 525-66-6
TTD Drug ID
DM79NTF
VARIDT Drug ID
DR00528
INTEDE Drug ID
DR1367
ACDINA Drug ID
D00565

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [20]
Norepinephrine DMOUC09 Alopecia ED70 Approved [21]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [22]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [22]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [22]
Timolol DM3NXRU High blood pressure BA00 Approved [23]
Isoproterenol DMK7MEY Atrioventricular block Approved [24]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [25]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [26]
Nadolol DMW6GVL Angina pectoris BA40 Approved [27]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [28]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Folic Acid DMEMBJC Colorectal carcinoma Approved [31]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [32]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [38]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [39]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [40]
Metformin DM89QE1 Colorectal carcinoma Approved [41]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [4]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [42]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [43]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [39]
Metformin DM89QE1 Colorectal carcinoma Approved [44]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [4]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [45]
Epinephrine DM3KJBC Acute asthma CA23 Approved [39]
Norepinephrine DMOUC09 Alopecia ED70 Approved [39]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [46]
Acetylcholine DMDF79Z Cataract 9B10 Approved [47]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [48]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [49]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [53]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [54]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [55]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [56]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [57]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [58]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [59]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [64]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [109]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [110]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [111]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [112]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [113]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [113]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [114]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [115]
Capsaicin DMGMF6V Back pain ME84.Z Approved [116]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [117]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [66]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [67]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [68]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [69]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [71]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [72]
Verapamil DMA7PEW Angina pectoris BA40 Approved [73]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [74]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [78]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [79]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [80]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [81]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [82]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [83]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [84]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [87]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [88]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [89]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [90]
Verapamil DMA7PEW Angina pectoris BA40 Approved [91]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [86]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [92]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [86]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [86]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [93]
Verapamil DMA7PEW Angina pectoris BA40 Approved [94]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [86]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [86]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [86]
Metronidazole DMTIVEN Abscess Approved [95]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [96]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [97]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [98]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [93]
Verapamil DMA7PEW Angina pectoris BA40 Approved [100]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [103]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [104]
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Drug(s) Metabolized By Dimethylaniline oxidase 2 (FMO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trifluoperazine DMKBYWI Anxiety Approved [11]
Ethionamide DM8K3EI Pulmonary tuberculosis 1B10.Z Approved [105]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [105]
Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [106]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [107]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [106]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [108]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [108]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [106]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [106]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [107]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [107]
GEA-6414 DM8J0MK N. A. N. A. Phase 1/2 [107]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [110]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [118]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [112]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [119]
Capsaicin DMGMF6V Back pain ME84.Z Approved [120]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [113]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [121]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [113]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [118]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [122]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Trifluoperazine DMKBYWI Anxiety Approved [11]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Testosterone enanthate DMB6871 N. A. N. A. Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [128]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [129]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [130]
PMID28454500-Compound-96 DM2A75P N. A. N. A. Patented [11]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [131]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [132]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [133]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [134]
Cepharanthine DM9Y5JB N. A. N. A. Approved [135]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [136]
Clozapine DMFC71L Schizophrenia 6A20 Approved [137]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [138]
Trifluoperazine DMKBYWI Anxiety Approved [139]
Olanzapine DMPFN6Y Bipolar depression Approved [137]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [140]
Quinidine DMLPICK N. A. N. A. Approved [141]
Verapamil DMA7PEW Angina pectoris BA40 Approved [142]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [143]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [143]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [144]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [145]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [146]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [143]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [147]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Atenolol DMNKG1Z Angina pectoris BA40 Approved [148]
Quinidine DMLPICK N. A. N. A. Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [150]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Mepivacaine DMH2NMY Analgesia MB40.8 Approved [150]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [152]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [152]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [150]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [156]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [158]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [159]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [161]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [162]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [164]
Gefitinib DM15F0X Colon adenocarcinoma Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Selenium DM25CGV N. A. N. A. Approved [154]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [167]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [168]
Methotrexate DM2TEOL Anterior urethra cancer Approved [169]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [170]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [171]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [172]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [173]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [174]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [178]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [164]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
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Drug(s) Affected By Angiopoietin-2 (ANGPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Panobinostat DM58WKG Chronic graft versus host disease Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [184]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [185]
Testosterone DM7HUNW Hot flushes GA30 Approved [186]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [186]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [188]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [188]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [189]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [190]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [191]
Etidronic acid DM1XHYJ Bone Paget disease Approved [188]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [188]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [188]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [192]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [193]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [194]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [195]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [196]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [197]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [198]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [199]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [200]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [201]
Epinephrine DM3KJBC Acute asthma CA23 Approved [202]
Chlorthalidone DM4DMBT Edema MG29 Approved [203]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [204]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [197]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [207]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [209]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [210]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [211]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [212]
Methotrexate DM2TEOL Anterior urethra cancer Approved [213]
Epinephrine DM3KJBC Acute asthma CA23 Approved [214]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [215]
Fructose DM43AN2 Vomiting MD90 Approved [216]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [218]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [219]
Testosterone DM7HUNW Hot flushes GA30 Approved [220]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [221]
Bambuterol DMKLSHF Asthma CA23 Approved [222]
Terbutaline DMD4381 Asthma CA23 Approved [223]
Salbutamol DMN9CWF Acute asthma CA23 Approved [224]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Epinephrine DM3KJBC Acute asthma CA23 Approved [227]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [228]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [230]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [231]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [232]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [233]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [122]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Verapamil DMA7PEW Angina pectoris BA40 Approved [235]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [236]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [237]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [242]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [242]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [243]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [244]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [245]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [247]
Isoproterenol DMK7MEY Atrioventricular block Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [248]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [249]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [250]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [251]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [252]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [253]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [238]
Gefitinib DM15F0X Colon adenocarcinoma Approved [254]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [255]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [256]
Selenium DM25CGV N. A. N. A. Approved [257]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [258]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [260]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [261]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [262]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [263]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [264]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [265]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [266]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [267]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [268]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [249]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [272]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [273]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [274]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [275]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [276]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [277]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [279]
Testosterone DM7HUNW Hot flushes GA30 Approved [280]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [281]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [282]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [283]
Mebendazole DMO14SG Ascariasis 1F62 Approved [284]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [122]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [122]
Haloperidol DM96SE0 Delirium Approved [122]
Pimozide DMW83TP Schizophrenia 6A20 Approved [122]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [286]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [287]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [288]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [163]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [291]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [292]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [293]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [294]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [294]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [296]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [297]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [299]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [300]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [236]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [303]
Meloxicam DM2AR7L Arthritis FA20 Approved [304]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [305]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [307]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [308]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [310]
Bortezomib DMNO38U Leukemia Approved [311]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [312]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-1 receptor (TEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [314]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Capsaicin DMGMF6V Back pain ME84.Z Approved [316]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [317]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [318]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [127]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [319]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [320]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [321]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [230]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [269]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Verapamil DMA7PEW Angina pectoris BA40 Approved [235]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [322]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [301]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Meloxicam DM2AR7L Arthritis FA20 Approved [325]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Delta-like protein 4 (DLL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [327]
Leflunomide DMR8ONJ Arthritis FA20 Approved [328]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [329]
Urethane DM7NSI0 N. A. N. A. Phase 4 [330]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [331]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [248]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [332]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [333]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [334]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [283]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [152]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [335]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [152]
Arsenic DMTL2Y1 N. A. N. A. Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [337]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [338]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [339]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [340]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [341]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [342]
Ethacrynic acid DM60QMR Edema MG29 Approved [343]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [344]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [345]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [347]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [113]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [112]
Capsaicin DMGMF6V Back pain ME84.Z Approved [120]
Zafirlukast DMHNQOG Asthma CA23 Approved [348]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [113]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [349]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [112]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [122]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [350]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [351]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [352]
Meloxicam DM2AR7L Arthritis FA20 Approved [353]
Quercetin DM3NC4M Obesity 5B81 Approved [354]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [355]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [356]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [357]
Retigabine DMGNYIH Behcet disease 4A62 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [247]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Pentobarbital DMFNH7L Brain ischaemia 8B1Z Approved [359]
Verapamil DMA7PEW Angina pectoris BA40 Approved [122]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [122]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [122]
Quinidine DMLPICK N. A. N. A. Approved [122]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [122]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [122]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [122]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [4]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [7]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [8]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [9]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [10]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [10]
Dimethylaniline oxidase 2 (FMO2) DEIASEZ FMO2_HUMAN Substrate [11]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [13]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Protein Interaction/Cellular Processes [14]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Gene/Protein Processing [15]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Gene/Protein Processing [15]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [16]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [15]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [15]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [17]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [18]
Beta-adrenergic receptor kinase 1 (GRK2) OT34KKWK ARBK1_HUMAN Gene/Protein Processing [19]

References

1 Propranolol FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7596).
3 Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
4 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
5 Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
6 Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15.
7 Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
8 Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol. 2001 Oct;52(4):349-55.
9 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
10 The influence of diltiazem versus cimetidine on propranolol metabolism. J Clin Pharmacol. 1992 Dec;32(12):1099-104.
11 Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82.
12 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
13 beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFB and AP-1. Cancer Biol Ther. 2010 Jul 1;10(1):19-29.
14 An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling. Mol Biol Cell. 2006 Jan;17(1):327-35. doi: 10.1091/mbc.e05-06-0523. Epub 2005 Nov 9.
15 Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chem Biol Interact. 2020 Jan 25;316:108925. doi: 10.1016/j.cbi.2019.108925. Epub 2019 Dec 12.
16 Labetalol (AH5158), a competitive alpha- and beta-receptor blocking drug, in the management of hypertension. Aust N Z J Med. 1976 Aug;6(3 Suppl):83-8. doi: 10.1111/j.1445-5994.1976.tb03341.x.
17 Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?. Biochem Pharmacol. 2004 Aug 15;68(4):783-90. doi: 10.1016/j.bcp.2004.05.006.
18 Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines. BMC Cancer. 2004 Dec 16;4:93. doi: 10.1186/1471-2407-4-93.
19 Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 1998 Oct 27;98(17):1783-9. doi: 10.1161/01.cir.98.17.1783.
20 Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77.
21 Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31.
22 Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6.
23 Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95.
24 Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
25 beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):519-29.
26 beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.
27 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
28 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
29 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
30 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
31 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
32 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
33 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
34 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
35 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
36 Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84.
37 Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells. Metallomics. 2018 Mar 1;10(3):414-425.
38 Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81.
39 Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52.
40 The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. Mol Reprod Dev. 2007 Oct;74(10):1303-11.
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