Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM87ZIH)

Drug Name
Tyrphostin ag-1478 Drug Info
Synonyms
AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; Tyrphostin AG-1478; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2051
ChEBI ID
CHEMBL7917
CAS Number
CAS 153436-53-4
TTD Drug ID
DM87ZIH
VARIDT Drug ID
DR01471

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [11]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [12]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [14]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [15]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [16]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [17]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [18]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [16]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [19]
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Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ozagrel DMIGKA1 Xerophthalmia 5B55.Y Phase 4 [19]
Losmapimod DMIL37Z Acute coronary syndrome BA41 Phase 3 [19]
VX-702 DMKJDR6 Coronary artery disease BA80 Phase 2a [20]
VX-745 DMJAEG6 Alzheimer disease 8A20 Phase 2 [21]
Dilmapimod DMBYJ92 Acute lung injury NB32.3 Phase 2 [19]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [22]
PMID25991433-Compound-F2 DM37VIQ N. A. N. A. Patented [22]
PMID25991433-Compound-L2 DM58UO9 N. A. N. A. Patented [22]
PMID25991433-Compound-L3 DM3LWUR N. A. N. A. Patented [22]
PMID25991433-Compound-L1 DM2135Y N. A. N. A. Patented [22]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Gefitinib DM15F0X Colon adenocarcinoma Approved [39]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [41]
Etretinate DM2CZFA Keratosis ED56 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
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Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [52]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [53]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [50]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [56]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [56]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [61]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [62]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [63]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [57]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [64]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [70]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [80]
Panobinostat DM58WKG Chronic graft versus host disease Approved [81]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [88]
Gefitinib DM15F0X Colon adenocarcinoma Approved [89]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [92]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [83]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [93]
Paclitaxel DMLB81S Breast carcinoma Approved [94]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [97]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [104]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [105]
Testosterone DM7HUNW Hot flushes GA30 Approved [106]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [107]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Propranolol DM79NTF Angina pectoris BA40 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [112]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [114]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [115]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [116]
Mebendazole DMO14SG Ascariasis 1F62 Approved [117]
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Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Leflunomide DMR8ONJ Arthritis FA20 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [125]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [10]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [2]
Stress-activated protein kinase 2a (p38 alpha) TTQBR95 MK14_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Gene/Protein Processing [8]
Keratin, type II cytoskeletal 1 (KRT1) OTIOJWA4 K2C1_HUMAN Gene/Protein Processing [8]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [9]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [9]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Gene/Protein Processing [8]
Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) OT37FKH0 CYLD_HUMAN Gene/Protein Processing [10]

References

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39 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
40 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
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49 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
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52 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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