Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM87ZIH)

Drug Name
Tyrphostin ag-1478 Drug Info
Synonyms
AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; Tyrphostin AG-1478; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2051
ChEBI ID
CHEBI:75404
CAS Number
CAS 153436-53-4
TTD Drug ID
DM87ZIH
VARIDT Drug ID
DR01471

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [11]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [12]
Gefitinib DM15F0X Colon adenocarcinoma Approved [13]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [14]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [15]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [16]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [17]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [18]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [16]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [19]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [58]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [60]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [61]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [66]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [67]
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Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ozagrel DMIGKA1 Xerophthalmia 5B55.Y Phase 4 [19]
Losmapimod DMIL37Z Acute coronary syndrome BA41 Phase 3 [19]
VX-702 DMKJDR6 Coronary artery disease BA80 Phase 2a [20]
VX-745 DMJAEG6 Alzheimer disease 8A20 Phase 2 [21]
Dilmapimod DMBYJ92 Acute lung injury NB32.3 Phase 2 [19]
PMID25991433-Compound-A1 DM89LF0 N. A. N. A. Patented [22]
PMID25991433-Compound-F2 DM37VIQ N. A. N. A. Patented [22]
PMID25991433-Compound-L2 DM58UO9 N. A. N. A. Patented [22]
PMID25991433-Compound-L3 DM3LWUR N. A. N. A. Patented [22]
PMID25991433-Compound-L1 DM2135Y N. A. N. A. Patented [22]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [23]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [34]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [35]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [36]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [37]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [38]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [43]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [51]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [53]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [57]
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Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [73]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [70]
Arsenic DMTL2Y1 N. A. N. A. Approved [74]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [76]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [77]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [79]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [82]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [84]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [89]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [90]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [91]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [85]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [92]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [79]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [98]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [96]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Selenium DM25CGV N. A. N. A. Approved [100]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [101]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [102]
Meloxicam DM2AR7L Arthritis FA20 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [105]
Epinephrine DM3KJBC Acute asthma CA23 Approved [106]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [113]
Panobinostat DM58WKG Chronic graft versus host disease Approved [114]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [115]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [118]
Gefitinib DM15F0X Colon adenocarcinoma Approved [59]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Selenium DM25CGV N. A. N. A. Approved [121]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [122]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [123]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [102]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [125]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fluoxetine DM3PD2C Bipolar depression Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [133]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [134]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [135]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [136]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [137]
Gefitinib DM15F0X Colon adenocarcinoma Approved [138]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [140]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [141]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [132]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [142]
Paclitaxel DMLB81S Breast carcinoma Approved [143]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [144]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [134]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [148]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [149]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [150]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [151]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [152]
Testosterone DM7HUNW Hot flushes GA30 Approved [153]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [154]
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Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [157]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [159]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [160]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [161]
Quercetin DM3NC4M Obesity 5B81 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [165]
Propranolol DM79NTF Angina pectoris BA40 Approved [166]
Testosterone DM7HUNW Hot flushes GA30 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [168]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [169]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [170]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [171]
Mebendazole DMO14SG Ascariasis 1F62 Approved [172]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Verapamil DMA7PEW Angina pectoris BA40 Approved [174]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [121]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [175]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [176]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [177]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [178]
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Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [182]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [183]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [184]
Testosterone DM7HUNW Hot flushes GA30 Approved [185]
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Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [188]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [189]
Leflunomide DMR8ONJ Arthritis FA20 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [192]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [193]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [194]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [188]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [2]
Stress-activated protein kinase 2a (p38 alpha) TTQBR95 MK14_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [5]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [7]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Gene/Protein Processing [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [9]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [9]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Gene/Protein Processing [10]
Keratin, type II cytoskeletal 1 (KRT1) OTIOJWA4 K2C1_HUMAN Gene/Protein Processing [10]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4862).
2 Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones. J Med Chem. 1999 Mar 25;42(6):1018-26.
3 Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5389-94.
4 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
5 GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via -catenin suppression in lung cancer cells. Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.
6 (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases. Chem Res Toxicol. 2015 May 18;28(5):897-906. doi: 10.1021/tx500518j. Epub 2015 Apr 21.
7 Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells. Toxicol Sci. 2016 Jul;152(1):62-71. doi: 10.1093/toxsci/kfw064. Epub 2016 Apr 12.
8 DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol. 2005 Jun;25(12):5040-51. doi: 10.1128/MCB.25.12.5040-5051.2005.
9 Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling. Toxicol In Vitro. 2016 Apr;32:212-9. doi: 10.1016/j.tiv.2015.12.013. Epub 2015 Dec 21.
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