Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD1B8Z)

Drug Name

Dobutamine Drug Info

Synonyms

Dobutamina; Dobutaminum; Dobutamine Hcl; Dobutamine [USAN]; Dobutamine hydrobromide; LY 81929; Lilly 81929; DL-dobutamine; Dobutamina [INN-Spanish]; Dobutamine Hcl in Dextrose 5%; Dobutamine(usp); Dobutaminum [INN-Latin]; Rac-dobutamine; Racemic-Dobutamine; Dobutamine (USP/INN); Dobutamine [USAN:BAN:INN]; Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer; (+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol; 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine; 4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol; 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol; 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Approved	[1]

Therapeutic Class

Cardiotonic Agents

Cross-matching ID

PubChem CID: 36811
ChEBI ID: CHEMBL926
CAS Number: CAS 34368-04-2
TTD Drug ID: DMD1B8Z
INTEDE Drug ID: DR1758

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[13]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[14]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[15]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[16]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[16]
Metoprolol	DMOJ0V6	Acute coronary syndrome	BA41	Approved	[16]
Timolol	DM3NXRU	High blood pressure	BA00	Approved	[17]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[18]
Betaxolol	DM6EUL5	Hypertension	BA00-BA04	Approved	[19]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[20]
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Drug(s) Metabolized By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[21]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[22]
METHYLENEDIOXYMETHAMPHETAMINE	DMYVU47	Discovery agent	N.A.	Investigative	[23]
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Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[28]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
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Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[34]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[35]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[35]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[36]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[34]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[35]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[37]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[34]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[38]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[39]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[40]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[41]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[43]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[44]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[45]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[46]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[47]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[48]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[51]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[52]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[55]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[57]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[8]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
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Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[62]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[66]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[62]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[63]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
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Drug(s) Affected By Kallikrein-1 (KLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[68]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[72]
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Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[79]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[80]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[81]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[82]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[83]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[84]
Terbutaline	DMD4381	Asthma	CA23	Approved	[85]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[86]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[89]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Agonist	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Catechol O-methyltransferase (COMT)^{Main DME}	DEV3T4A	COMT_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Drug Response	[4]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Drug Response	[5]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[8]
Kallikrein-1 (KLK1)	OTFGP3UR	KLK1_HUMAN	Drug Response	[9]
Neuroendocrine secretory protein 55 (GNAS)	OTMH8BKJ	GNAS3_HUMAN	Drug Response	[10]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[11]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Gene/Protein Processing	[8]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Drug Response	[12]

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