Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD2CG9)

• Drug Name: PD-0166326 Drug Info
• Synonyms: PD-166326

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 447700
  CAS Number: CAS 185039-91-2
  TTD Drug ID: DMD2CG9

Molecule-Related Drug Atlas

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[6]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[6]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[7]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[6]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[8]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[10]
Intedanib	DMSTA36	Colorectal cancer	2B91.Z	Approved	[11]
Pemigatinib	DM819JF	Cholangiocarcinoma	2C12.10	Approved	[12]
Infigratinib	DMNKBEC	Cholangiocarcinoma	2C12.10	Approved	[13]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
Sulfatinib	DMPOTM4	Neuroendocrine cancer	2B72.1	Phase 3	[15]
ARQ-087	DM02BVQ	Intrahepatic cholangiocarcinoma	2C12.10	Phase 3	[16]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[17]
Debio 1347	DMZW50O	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
AM-001	DMGVQI8	Actinic keratosis	EK90.0	Phase 2	[19]

Drug(s) Targeting Platelet-derived growth factor receptor alpha (PDGFRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[20]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[21]
Olaratumab	DMNYOIX	Soft tissue sarcoma	2B57	Approved	[22]
Avapritinib	DMK2GZX	Gastrointestinal stromal tumour	2B5B	Approved	[23]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[24]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[25]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[26]
MP470	DMELUAK	Solid tumour/cancer	2A00-2F9Z	Phase 2	[27]
MEDI-575	DMI9WVM	Glioblastoma multiforme	2A00.0	Phase 2	[28]

Drug(s) Targeting Tyrosine-protein kinase Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[29]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[30]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[31]
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[32]
Pexidartinib	DMS2J0Z	Tenosynovial giant cell tumour	2F7B	Approved	[33]
Ripretinib	DM958QB	Gastrointestinal stromal tumour	2B5B	Approved	[21]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[25]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[26]

Drug(s) Targeting Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[29]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[20]
Becaplermin	DM1R5X4	Diabetic complication	5A2Y	Approved	[34]
E-3810	DM42PFT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
Famitinib	DMSFWT7	Solid tumour/cancer	2A00-2F9Z	Phase 2	[25]
XL-820	DMMHX9K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[26]
MK-2461	DM21WBH	Alzheimer disease	8A20	Phase 1/2	[35]
SNN-0031	DM2X3BR	Brain injury	NA07.Z	Phase 1/2	[36]
TAK-593	DMNFZOT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[37]
Pyridine derivative 18	DMBZMYT	N. A.	N. A.	Patented	[38]

Drug(s) Targeting Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[39]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[40]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[41]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[42]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Dacomitinib	DMOH8VY	Non-small-cell lung cancer	2C25.Y	Approved	[43]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[44]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[45]
Epidermal growth factor	DMVONE6	Vulnerary	ND56.Z	Approved	[43]
Merimepodib	DM0HS92	Breast cancer	2C60-2C65	Approved	[46]

Drug(s) Targeting Tyrosine-protein kinase ABL1 (ABL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ponatinib	DMYGJQO	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[45]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[47]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[48]
Flumatinib	DM0G5O6	Chronic myelogenous leukaemia	2A20.0	Phase 2	[49]
DCC-2036	DMJKFNU	Chronic myeloid leukaemia	2A20	Phase 1/2	[50]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[51]
KW-2449	DMFO7RP	Acute myeloid leukaemia	2A60	Phase 1	[52]
IkT-148009	DMMJ9HY	Parkinson disease	8A00.0	Phase 1	[53]

Drug(s) Targeting Stress-activated protein kinase 2a (p38 alpha)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ozagrel	DMIGKA1	Xerophthalmia	5B55.Y	Phase 4	[46]
Losmapimod	DMIL37Z	Acute coronary syndrome	BA41	Phase 3	[46]
VX-702	DMKJDR6	Coronary artery disease	BA80	Phase 2a	[54]
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[55]
Dilmapimod	DMBYJ92	Acute lung injury	NB32.3	Phase 2	[46]
PMID25991433-Compound-A1	DM89LF0	N. A.	N. A.	Patented	[56]
PMID25991433-Compound-F2	DM37VIQ	N. A.	N. A.	Patented	[56]
PMID25991433-Compound-L2	DM58UO9	N. A.	N. A.	Patented	[56]
PMID25991433-Compound-L3	DM3LWUR	N. A.	N. A.	Patented	[56]
PMID25991433-Compound-L1	DM2135Y	N. A.	N. A.	Patented	[56]

Drug(s) Targeting Proto-oncogene c-Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[3]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[45]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[57]
AL3818	DM3WP0N	Alveolar soft part sarcoma	2A60-2C35	Phase 3	[18]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[18]
Masitinib	DMRSNEU	Amyotrophic lateral sclerosis	8B60.0	Phase 3	[58]
KX-01	DMF0NA9	Actinic keratosis	EK90.0	Phase 3	[59]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[48]
TPX-0046	DMIVE67	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[60]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Inhibitor	[2]
Fibroblast growth factor receptor 1 (FGFR1)	TTRLW2X	FGFR1_HUMAN	Inhibitor	[2]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[2]
Platelet-derived growth factor receptor alpha (PDGFRA)	TT8FYO9	PGFRA_HUMAN	Inhibitor	[2]
Platelet-derived growth factor receptor beta (PDGFRB)	TTI7421	PGFRB_HUMAN	Inhibitor	[2]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[1]
Stress-activated protein kinase 2a (p38 alpha)	TTQBR95	MK14_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase ABL1 (ABL)	TT3PJMV	ABL1_HUMAN	Inhibitor	[1]
Tyrosine-protein kinase Kit (KIT)	TTX41N9	KIT_HUMAN	Inhibitor	[1]

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