Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5CK3)

Drug Name

eucalyptol Drug Info

Synonyms

Eucalyptol; cineole; 1,8-Cineole; 1,8-Cineol; Cajeputol; 470-82-6; 1,8-Epoxy-p-menthane; Eucalyptole; Zineol; Eucapur; Terpan; p-Cineole; 1,8-Oxido-p-menthane; 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane; Eukalyptol; CINEOL; Cucalyptol; Soledum; Eukalyptol [Czech]; Zedoary oil; Eucalyptol (natural); EUCALYPTUS OIL; p-Menthane, 1,8-epoxy-; Cineole (VAN); 2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-; NCI-C56575; Eucalyptol [USAN]; UNII-RV6J6604TK; FEMA No. 2465; 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-; NSC 6171

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2758
ChEBI ID: CHEBI:27961
CAS Number: CAS 470-82-6
TTD Drug ID: DME5CK3

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Preclinical Drug(s)

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Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[7]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[9]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[10]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[11]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[12]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[13]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[12]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[11]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[12]
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Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[14]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[15]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[16]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[21]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
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Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[28]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[25]
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Drug(s) Affected By Ankyrin repeat domain-containing protein 17 (ANKRD17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[31]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[38]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[38]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[40]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[45]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[46]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
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Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
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Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[64]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[65]
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Drug(s) Affected By E3 ubiquitin-protein ligase TRIM21 (TRIM21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[75]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[72]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
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Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[85]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[86]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[87]
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Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[90]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[91]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[94]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[95]
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Drug(s) Affected By Protein-tyrosine kinase 6 (PTK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[93]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[99]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[100]
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Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[105]
Mestranol	DMG3F94	Contraception	QA21	Approved	[102]
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Drug(s) Affected By Mucin-19 (MUC19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[106]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[109]
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Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[110]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[112]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[110]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[113]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[114]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[115]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[121]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[122]
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Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
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Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[128]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[129]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[130]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[131]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[135]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[136]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[137]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[138]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[139]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[140]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[138]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[138]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[141]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[142]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[144]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[3]
Achaete-scute homolog 1 (ASCL1)	OTI4X44G	ASCL1_HUMAN	Gene/Protein Processing	[4]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat domain-containing protein 17 (ANKRD17)	OTQ3DYEP	ANR17_HUMAN	Gene/Protein Processing	[4]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Gene/Protein Processing	[5]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Biotransformations	[6]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Biotransformations	[6]
E3 ubiquitin-protein ligase TRIM21 (TRIM21)	OTA4UJCF	RO52_HUMAN	Gene/Protein Processing	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2464).
2	Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002 Mar 7;416(6876):52-8.
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