Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNPZL4)

Drug Name
Dacarbazine Drug Info
Synonyms
Biocarbazin; Biocarbazine; DTIC; DTICDome; DTIE; Dacarbazino; Dacarbazinum; Dacatic; Decarbazine; Deticene; Dimethyltriazenoimidazolecarboxamide; ICDMT; ICDT; Biocarbazine R; DTIC Dome; Dimethyl Imidazole Carboxamide; Dimethyl Triazeno Imidazole Carboxamide; Imidazole carboxamide; HE1150000; Carboxamide (TN); Carboxamide, Dimethyl Imidazole; DIC (TN); DTIC (TN); DTIC-Dome; Dacarbazino [INN-Spanish]; Dacarbazinum [INN-Latin]; Imidazole (TN); Imidazole Carboxamide, Dimethyl; NPFAPI-05; DTIC-Dome (TN); Di-me-triazenoimidazolecarboxamide; Di-methyl-triazenoimidazolecarboxamide; Dtic-Dome (TN); DTIC, DTIC-Dome, Dacarbazine; Dacarbazine (JAN/USP/INN); Dacarbazine [USAN:INN:BAN:JAN]; (5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; (5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; (Dimethyltriazeno)imidazolecarboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide; 4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide; 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4-(Dimethyltriazeno)imidazole-5-c arboxamide; 4-(Dimethyltriazeno)imidazole-5-carboxamide; 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide; 4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; 4-[3,3-dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; 5(or 4)-(dimethyltriazeno)imidazol e-4(or 5)-carboxamide; 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; 5-(3,3-Dimethyltri azeno)imidazole-4-carboxamide; 5-(3,3-Dimethyltriazeno)-imidazole-4-carbamide; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; 5-(Dimethyltriazeno)-4-imidazolecarboxamide; 5-(Dimethyltriazeno)imidazole-4-carboxamide; 5-(Dimethyltriazeno)imidazole-4-carboximide; 5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; 5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [1]
Astrocytoma 2A00.0Y Approved [1]
Brain disease 8C70-8E61 Approved [1]
Central nervous system disease 8A04-8D87 Approved [1]
Glioblastoma 2A00 Approved [1]
Gliosarcoma Approved [1]
Melanoma 2C30 Approved [2]
Classic Hodgkin lymphoma Investigative [1]
Neuroblastoma 2D11.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
135398738
ChEBI ID
CHEMBL476
CAS Number
CAS 4342-03-4
TTD Drug ID
DMNPZL4
INTEDE Drug ID
DR0404
ACDINA Drug ID
D00979

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [14]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [15]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [16]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [17]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [18]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [19]
Procarbazine DMIK367 Hodgkin lymphoma 2B30 Approved [20]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [21]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [22]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Estrone DM5T6US Acne vulgaris ED80 Approved [38]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [39]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [40]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [43]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [48]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [49]
Ethanol DMDRQZU Chronic pain MG30 Approved [50]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Etretinate DM2CZFA Keratosis ED56 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [61]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [64]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [65]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [67]
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Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [71]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [74]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [76]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [77]
Topotecan DMP6G8T Central nervous system neoplasm Approved [78]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [78]
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Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [81]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [82]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [85]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [87]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [88]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [103]
Gefitinib DM15F0X Colon adenocarcinoma Approved [104]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [107]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [108]
Paclitaxel DMLB81S Breast carcinoma Approved [109]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [110]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [97]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [111]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [112]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [101]
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Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Menthol DMG2KW7 Back pain ME84.Z Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Paclitaxel DMLB81S Breast carcinoma Approved [119]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [83]
Arsenic DMTL2Y1 N. A. N. A. Approved [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [4]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [7]
DNA repair nuclease/redox regulator APEX1 (APEX1) OT53OI14 APEX1_HUMAN Drug Response [8]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [9]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Gene/Protein Processing [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Drug Response [11]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Drug Response [11]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Drug Response [11]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Drug Response [12]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [9]

References

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32 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
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34 Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74.
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38 A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6.
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41 Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62.
42 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
43 Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96.
44 Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9.
45 Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55.
46 A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300.
47 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
48 Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. Drug Metab Dispos. 2000 Feb;28(2):110-2.
49 Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6.
50 CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
51 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
52 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
53 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
54 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
55 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
56 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
57 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
58 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
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