Details of the Drug-Related molecule(s) Interaction Atlas

Taxifolin Drug Info

TAXIFOLIN; (+)-Taxifolin; dihydroquercetin; Distylin; Taxifoliol; (2R,3R)-Dihydroquercetin; (+)-Dihydroquercetin; TAXIFOLIN-(+); Lavitol; Lariksin; taxifolin (dihydroquercetin); 3,5,7,3',4'-Pentahydroxyflavanone; UNII-9SOB9E3987; trans-Dihydroquercetin; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; (+)-trans-Taxifolin; (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE; (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone

Cross-matching ID

PubChem CID

439533

ChEBI ID

CHEMBL66

CAS Number

CAS 480-18-2

TTD Drug ID

DMQJSF9

VARIDT Drug ID

DR01605

General Information of Drug (ID: DMQJSF9)

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[7]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[8]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[12]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[13]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[14]
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Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[19]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
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Drug(s) Affected By Fibroblast growth factor 3 (FGF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
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Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[36]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[40]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[45]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
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Drug(s) Affected By Netrin receptor DCC (DCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[52]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[47]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[53]
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Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[56]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[59]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[60]
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Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[51]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[66]
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Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[68]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[67]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[71]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[73]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[67]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[77]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[51]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[82]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[83]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[87]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[90]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[77]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[51]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[36]
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Drug(s) Affected By POTE ankyrin domain family member E (POTEE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[81]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[98]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[2]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Post-Translational Modifications	[2]
Cyclin-A1 (CCNA1)	OTX4HD45	CCNA1_HUMAN	Gene/Protein Processing	[3]
DNA repair protein complementing XP-A cells	OTO2MEFR	XPA_HUMAN	Gene/Protein Processing	[3]
DNA repair protein XRCC4	OT4SXOIZ	XRCC4_HUMAN	Gene/Protein Processing	[3]
Fibroblast growth factor 3 (FGF3)	OT9PK2SI	FGF3_HUMAN	Gene/Protein Processing	[3]
Growth arrest-specific protein 6 (GAS6)	OTPOPUUE	GAS6_HUMAN	Gene/Protein Processing	[3]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Gene/Protein Processing	[3]
Microsomal triglyceride transfer protein large subunit (MTTP)	OTNUVSDT	MTP_HUMAN	Gene/Protein Processing	[4]
Netrin receptor DCC (DCC)	OT2C1SHW	DCC_HUMAN	Gene/Protein Processing	[3]

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