Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRJKIV)

Drug Name
Caffeic acid phenethyl ester Drug Info
Synonyms
Caffeic acid phenethyl ester; Phenethyl caffeate; 104594-70-9; CAPE; phenethyl 3-(3,4-dihydroxyphenyl)acrylate; Capeee; Phenylethyl caffeate; 115610-29-2; caffeic acid phenylethyl ester; UNII-G960R9S5SK; 2-phenylethyl caffeate; PHENETHYL CAFFEATE (CAPE); Caffeic acid-phenethyl ester; CHEBI:8062; G960R9S5SK; CHEMBL319244; 100981-80-4; Caffeic acid 2-phenylethyl ester; SWUARLUWKZWEBQ-VQHVLOKHSA-N; 2-phenylethyl 3-(3,4-dihydroxyphenyl)-2-propenoate; Caffeic Acid Phenethyl Ester, Synthetic; 2-Phenylethyl (2e)-3-(3,4-Dihydroxyphenyl
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281787
ChEBI ID
CHEMBL319244
CAS Number
CAS 115610-29-2
TTD Drug ID
DMRJKIV
INTEDE Drug ID
DR2154

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [9]
Triptolide DMCMDVR Autoimmune diabetes 5A10 Phase 3 [10]
Laquinimod DM3IWS8 Lupus 4A40 Phase 3 [11]
Edasalonexent DMYVBF6 Duchenne dystrophy 8C70 Phase 3 [12]
MD1003 DMVZ57G Multiple sclerosis 8A40 Phase 3 [12]
Vadimezan DMK7CYX Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
CAT 1004 DMQBP7R Duchenne dystrophy 8C70 Phase 2 [14]
Parthenolide DMCQBFT N. A. N. A. Phase 2 [15]
Recoflavone DMCSR8I Inflammatory bowel disease DD72 Phase 2 [16]
CZEN-002 DMUDMHA Fungal infection 1F29-1F2F Phase 2 [17]
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Drug(s) Metabolized By Amylosucrase (AMS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
7,8,4'-trihydroxyisoflavone DM80GFL Discovery agent N.A. Investigative [18]
Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [23]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [24]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [25]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [28]
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Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [34]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [35]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [28]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [5]
Diazepam DM08E9O Alcohol withdrawal Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [37]
Benzbromarone DMC3YUA Gout FA25 Approved [38]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [36]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [36]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [39]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [40]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [42]
Diazepam DM08E9O Alcohol withdrawal Approved [36]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [43]
Desogestrel DM27U4Y Contraception QA21 Approved [43]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [42]
Diazepam DM08E9O Alcohol withdrawal Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [51]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [42]
Diazepam DM08E9O Alcohol withdrawal Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [55]
Ethacrynic acid DM60QMR Edema MG29 Approved [53]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [66]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [67]
Paclitaxel DMLB81S Breast carcinoma Approved [68]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [70]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Etretinate DM2CZFA Keratosis ED56 Approved [77]
Prednisone DM2HG4X Acute asthma CA23 Approved [78]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [79]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [80]
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Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Benzatropine DMF7EXL Parkinsonian disorder Approved [83]
Clozapine DMFC71L Schizophrenia 6A20 Approved [83]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [84]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Arsenic DMTL2Y1 N. A. N. A. Approved [86]
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Drug(s) Affected By Claudin-2 (CLDN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [91]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [35]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [92]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [94]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [95]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [102]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [95]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [96]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [105]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [102]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
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Drug(s) Affected By CCAAT/enhancer-binding protein epsilon (CEBPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [85]
Pomalidomide DMTGBAX Plasma cell myeloma 2A83.1 Approved [113]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [114]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [115]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [116]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [117]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nuclear factor NF-kappa-B (NFKB) TTSXVID NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Dextransucrase 4 (dsrF4) DE1KTC4 GTF4_LEUME Substrate [2]
Dextransucrase 3 (dsrF3) DED68N5 GTF3_LEUME Substrate [2]
Dextransucrase 2 (dsrF2) DE174E0 GTF2_LEUME Substrate [2]
Dextransucrase 1 (dsrF1) DEEPQJ8 GTF1_LEUME Substrate [2]
Amylosucrase (AMS) DEEZYQV Q1J0W0_DEIGD Substrate [3] , [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [5]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Gene/Protein Processing [5]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [6]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [6]
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Post-Translational Modifications [7]
CCAAT/enhancer-binding protein epsilon (CEBPE) OTKZA25M CEBPE_HUMAN Gene/Protein Processing [8]

References

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2 Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512.
3 The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet. 2009 Mar;5(3):e1000416.
4 Glycosylation enhances the physicochemical properties of caffeic acid phenethyl ester. J Microbiol Biotechnol. 2017 Nov 28;27(11):1916-1924.
5 Initro CAPE inhibitory activity towards human AKR1C3 and the molecular basis. Chem Biol Interact. 2016 Jun 25;253:60-5.
6 Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins. BJU Int. 2004 Aug;94(3):402-6. doi: 10.1111/j.1464-410X.2004.04936.x.
7 Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. Clin Cancer Res. 2000 Mar;6(3):949-56.
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11 Reduced astrocytic NF- B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep;124(3):411-24.
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19 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
20 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
21 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
22 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
23 Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
24 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
25 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
26 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
27 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
28 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
29 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
30 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
31 Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation. Chem Biol Interact. 2009 Mar 16;178(1-3):250-8. doi: 10.1016/j.cbi.2008.11.007. Epub 2008 Nov 18.
32 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
33 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
34 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
35 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
36 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
37 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
38 Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone. Chem Biol Interact. 2003 Feb 1;143-144:503-13.
39 Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
40 Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
41 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
42 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
43 Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
44 In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
45 AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
46 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
47 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
48 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
49 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
50 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
51 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
52 Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
53 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
54 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
55 Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
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