Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU1GX0)

Drug Name
Mitotane Drug Info
Synonyms
Chloditan; Chlodithan; Chlodithane; Khloditan; Khlodithan; Lysodren; Mitotan; Mitotano; Mitotanum; Mytotan; Bristol Myers Squibb Brand of Mitotane; C 3010; CB 313; CB313; PS694_SUPELCO; Bristol-Myers Squibb Brand of Mitotane; CB-313; Lysodren (TN); Mitotano [INN-Spanish]; Mitotanum [INN-Latin]; Ortho,para DDD; Mitotane [USAN:INN:JAN]; O,p-DDD; O,p-Tde; Ortho,para-DDD; Mitotane (JAN/USP/INN); O,p'-DDD; O,p'-Dichlorodiphenyldichloroethane; O,p'-TDE; Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-(8CI); (+-)-1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; (2,4'-Dichlorodiphenyl)dichloroethane; (o,p)-DDD; 1,1-Dichloro-2,2-bis(2,4'-dichlorophenyl)ethane; 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,1-Dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl)ethane; 1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane; 1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; 2,4'-Ddd; 2,4'-Dichlorodiphenyldichloroethane; 2,4'-Dichlorophenyldichlorethane; 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloroethane
Indication
Disease Entry ICD 11 Status REF
Adrenocortical carcinoma 2D11.Z Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
4211
ChEBI ID
CHEMBL1670
CAS Number
CAS 53-19-0
TTD Drug ID
DMU1GX0
ACDINA Drug ID
D00441

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen receptor (ESR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [9]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [10]
Estrone DM5T6US Acne vulgaris ED80 Approved [10]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [11]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [11]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [11]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [12]
Raloxifene DMDKF3M Osteoporosis FB83.0 Approved [13]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [14]
Toremifene DMQYUWG Breast cancer 2C60-2C65 Approved [15]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [16]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [17]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [17]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [20]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [16]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [21]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [22]
Levetiracetam DMTGDN8 Epilepsy 8A60-8A68 Approved [19]
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Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Ethanol DMDRQZU Chronic pain MG30 Approved [28]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [29]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [30]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [31]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [36]
Prednisone DM2HG4X Acute asthma CA23 Approved [37]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
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Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [45]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [49]
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Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [52]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [53]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [53]
Menthol DMG2KW7 Back pain ME84.Z Approved [57]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [58]
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Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [59]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [32]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [65]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [66]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [66]
Fructose DM43AN2 Vomiting MD90 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [66]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [71]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [72]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [74]
Etidronic acid DM1XHYJ Bone Paget disease Approved [71]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [71]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [76]
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Drug(s) Affected By Sex hormone-binding globulin (SHBG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Fructose DM43AN2 Vomiting MD90 Approved [78]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [79]
Estrone DM5T6US Acne vulgaris ED80 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [80]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [80]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [80]
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Drug(s) Affected By Glia-derived nexin (SERPINE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [56]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [89]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [90]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [91]
Cepharanthine DM9Y5JB N. A. N. A. Approved [92]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [93]
Clozapine DMFC71L Schizophrenia 6A20 Approved [94]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [95]
Trifluoperazine DMKBYWI Anxiety Approved [96]
Olanzapine DMPFN6Y Bipolar depression Approved [94]
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Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [101]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [21]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [103]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [104]
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Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [107]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Testosterone enanthate DMB6871 N. A. N. A. Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [112]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [113]
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Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [114]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [117]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [119]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Fluoxetine DM3PD2C Bipolar depression Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [120]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [102]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Propranolol DM79NTF Angina pectoris BA40 Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [131]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [132]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [113]
Mebendazole DMO14SG Ascariasis 1F62 Approved [133]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
Artemether DM48QOT Malaria 1F40-1F45 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [138]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [139]
Estrone DM5T6US Acne vulgaris ED80 Approved [140]
Leflunomide DMR8ONJ Arthritis FA20 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
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Drug(s) Affected By Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Panobinostat DM58WKG Chronic graft versus host disease Approved [142]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [144]
Indomethacin DMSC4A7 Bursitis Approved [145]
Arsenic DMTL2Y1 N. A. N. A. Approved [146]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [147]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [148]
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Drug(s) Affected By Thyroid hormone-inducible hepatic protein (THRSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [125]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [5]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [45]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [150]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [87]
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Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [153]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [154]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [155]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [85]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [156]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [157]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Binder [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Gene/Protein Processing [3]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [5]
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) OT589JA2 KAP0_HUMAN Gene/Protein Processing [6]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Gene/Protein Processing [7]
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Gene/Protein Processing [7]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Gene/Protein Processing [8]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Gene/Protein Processing [3]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Gene/Protein Processing [5]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Gene/Protein Processing [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6957).
2 Mitotane for adrenocortical carcinoma treatment. Curr Opin Investig Drugs. 2005 Apr;6(4):386-94.
3 Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: a microarray study. Pharmacogenomics. 2012 Sep;13(12):1351-61. doi: 10.2217/pgs.12.116.
4 Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):281-9.
5 Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
6 The effect of mitotane on viability, steroidogenesis and gene expression in NCI295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.
7 Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells. Endocr Relat Cancer. 2013 May 21;20(3):371-81.
8 Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis. 2009 Jan;30(1):106-13. doi: 10.1093/carcin/bgn213. Epub 2008 Sep 12.
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