Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUNK59)

Drug Name
Bafilomycin A1 Drug Info
Synonyms
bafilomycin A1; 88899-55-2; MFCD06795130; CHEMBL290814; CHEBI:22689; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one; Bafilomycin; NSC381866; Bafilomycin A1/; Hygrolidin, 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-; Bafilomycin A1 from Streptomyces griseus; BSPBio_001470; MEGxm0_000385; SCHEMBL13775181; ACon0_000813; HMS3402J12; Bafilomycin A1 Ready Made Solution; ABP000610; BDBM50064186; AKOS030213158; ZINC169647947; DB06733; MCULE-2359469972; NCGC00163426-02; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one; Q4841341; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyl-tetrahydropyran-2-yl]-2-hydroxy-1-methyl-butyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Indication
Disease Entry ICD 11 Status REF
B-cell acute lymphoblastic leukaemia 2B33.3 Investigative [1]
Cross-matching ID
PubChem CID
6436223
ChEBI ID
CHEMBL290814
CAS Number
CAS 88899-55-2
TTD Drug ID
DMUNK59

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Vacuolar-type proton ATPase (v-ATPase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
WY-47766 DM7VCDZ Osteoporosis FB83.0 Discontinued in Phase 2 [11]
SB 242784 DMFXJDL Arterial calcification BD52.Y Preclinical [12]
Salicylihalamide A DMGXVRZ Solid tumour/cancer 2A00-2F9Z Preclinical [13]
FR167356 DMF53Z7 Osteoporosis FB83.0 Preclinical [14]
Lobatamide A DM2GBEW Discovery agent N.A. Investigative [13]
Lobatamide C DMFIDJS Discovery agent N.A. Investigative [13]
Oximidine II DMW6K80 Discovery agent N.A. Investigative [13]
Lobatamide D DMG706J Discovery agent N.A. Investigative [13]
Lobatamide B DMD91RI Discovery agent N.A. Investigative [13]
Oximidine I DMG6O0L Discovery agent N.A. Investigative [13]
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Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [21]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [36]
Paclitaxel DMLB81S Breast carcinoma Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [39]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [29]
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Drug(s) Affected By Steroidogenic factor 1 (NR5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [42]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [45]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
27-hydroxycholesterol DM2L6OZ Discovery agent N.A. Investigative [48]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [49]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [56]
Leflunomide DMR8ONJ Arthritis FA20 Approved [57]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [58]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [59]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [60]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [39]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [61]
Diazepam DM08E9O Alcohol withdrawal Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [64]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [78]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [78]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [79]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [83]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
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Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [92]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [93]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [95]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [97]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [98]
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Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Selenium DM25CGV N. A. N. A. Approved [99]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [101]
Testosterone DM7HUNW Hot flushes GA30 Approved [97]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Ethanol DMDRQZU Chronic pain MG30 Approved [104]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [105]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [108]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [109]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [112]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [113]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [115]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [112]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [24]
Capsaicin DMGMF6V Back pain ME84.Z Approved [117]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [118]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [119]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
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Drug(s) Affected By Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Clozapine DMFC71L Schizophrenia 6A20 Approved [122]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [124]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [125]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [126]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [127]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vacuolar-type proton ATPase (v-ATPase) TTTK3BH NOUNIPROTAC Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [3]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Gene/Protein Processing [4]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Gene/Protein Processing [5]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Protein Interaction/Cellular Processes [6]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) OTLS7C99 LRRK2_HUMAN Drug Response [7]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Gene/Protein Processing [8]
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) OTPMGIU4 MLP3A_HUMAN Gene/Protein Processing [9]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Protein Interaction/Cellular Processes [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Gene/Protein Processing [4]

References

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