Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXO6YH)

Drug Name
PJ34 Drug Info
Synonyms
PJ34; 344458-19-1; pj-34; N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE; CHEMBL372303; P34; 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide; Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-; UYJZZVDLGDDTCL-UHFFFAOYSA-N; PJ34(free base); 1xk9; SCHEMBL422317; ZINC8960; AC1L1J45; BDBM27497; CTK1B7701; MolPort-035-395-737; Ibrutinib (PCI32765 pound(c); HMS3651B06; BCP07990; HY-13688A; 2662AH; AKOS030229047; SB19292; DB08348; CS-1463; NCGC00370866-10; DA-42692; BC600341
Indication
Disease Entry ICD 11 Status REF
Coronavirus infection 1D92 Preclinical [1]
Cross-matching ID
PubChem CID
4858
ChEBI ID
CHEMBL372303
TTD Drug ID
DMXO6YH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [11]
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [12]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [13]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [14]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [15]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [16]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [17]
AG140699 DMA9FKY Melanoma 2C30 Phase 2 [18]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [19]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [20]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Etretinate DM2CZFA Keratosis ED56 Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
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Drug(s) Affected By Transient receptor potential cation channel subfamily M member 2 (TRPM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [33]
Arsenic DMTL2Y1 N. A. N. A. Approved [34]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
Drug(s) Affected By Poly polymerase tankyrase-1 (TNKS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Urethane DM7NSI0 N. A. N. A. Phase 4 [42]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [43]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [51]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [61]
Panobinostat DM58WKG Chronic graft versus host disease Approved [62]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [65]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [66]
Etretinate DM2CZFA Keratosis ED56 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
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Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [95]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [97]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [98]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [99]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Etretinate DM2CZFA Keratosis ED56 Approved [25]
Prednisone DM2HG4X Acute asthma CA23 Approved [104]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [105]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [106]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
Gefitinib DM15F0X Colon adenocarcinoma Approved [108]
Prednisone DM2HG4X Acute asthma CA23 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [110]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Fluoxetine DM3PD2C Bipolar depression Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [123]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [24]
Selenium DM25CGV N. A. N. A. Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [127]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
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Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [133]
Menthol DMG2KW7 Back pain ME84.Z Approved [134]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [137]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [138]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [139]
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Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP15 (PARP15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [140]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [141]
Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP14 (PARP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [144]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [146]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [147]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [148]
Urethane DM7NSI0 N. A. N. A. Phase 4 [42]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [149]
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Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP16 (PARP16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [145]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [151]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [139]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [152]
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Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [157]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [133]
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Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [158]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
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Drug(s) Affected By Poly polymerase tankyrase-2 (TNKS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [160]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [161]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [162]
Milchsaure DM462BT Pruritus EC90 Investigative [163]
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Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [166]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [167]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [145]
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Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [133]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [136]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [169]
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Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [170]
Arsenic DMTL2Y1 N. A. N. A. Approved [171]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [174]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [176]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [177]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [32]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [178]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [177]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [3]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [4]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [5]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Drug Response [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [7]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Gene/Protein Processing [8]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Gene/Protein Processing [9]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [10]

References

1 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
2 Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13.
3 PARP inhibitor activates the intrinsic pathway of apoptosis in primary lung cancer cells. Cancer Invest. 2014 Aug;32(7):339-48. doi: 10.3109/07357907.2014.919303. Epub 2014 Jun 4.
4 Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells. Pharmacol Rep. 2016 Dec;68(6):1225-1229. doi: 10.1016/j.pharep.2016.08.001. Epub 2016 Aug 2.
5 PARP-1 inhibitor modulate -catenin signaling to enhance cisplatin sensitivity in cancer cervix. Oncotarget. 2019 Jul 2;10(42):4262-4275. doi: 10.18632/oncotarget.27008. eCollection 2019 Jul 2.
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