Details of Disease

General Information of Disease (ID: DISFZHKN)

• Disease Name: Bacillary dysentery
• Synonyms: flexner's dysentery; Shigella dysentery; japanese dysentery; Shigella flexneri infectious disease; Shigella boydii infectious disease; Shigella sonnei infectious disease; shigellosis; bacillary dysentery; Shigella gastroenteritis
• Disease Class: 1A02: Shigella intestinal infection
• Definition: Shigellosis is a bacterial infection leading to dysentery and is caused by Shigella, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: S. dysenteriae, S. flexneri, S. boydii and S. sonnei, all of which cause bacillary dysentery and are strictly limited to human hosts.
• Disease Hierarchy:
  DISKICS2: Dysentery
  DIS8ZVFW: Primary bacterial infectious disease
  DISKU8JE: Large intestine disorder
  DISEM33Q: Infectious disease
  DISFZHKN: Bacillary dysentery
• ICD Code:
  ICD-11: ICD-11: 1A02
  Expand ICD-11: '1A02
  Expand ICD-10: 'A03; 'A03.0; 'A03.1; 'A03.2; 'A03.3; 'A03.9
  Expand ICD-9: 1.00E+183
• Disease Identifiers:
  MONDO ID: MONDO_0019345
  MESH ID: D004405
  UMLS CUI: C0013371
  MedGen ID: 8513
  Orphanet ID: 810
  SNOMED CT ID: 111817006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 10 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ampicillin	DMHWE7P	Approved	Small molecular drug	[1]
Andrographolide	DMW73W6	Approved	Small molecular drug	[2]
Ciprofloxacin XR	DM2NLS9	Approved	Small molecular drug	[3]
Hemsleyadin	DMJ3C2C	Approved	NA	[2]
Neoandrographolide	DMT1GFP	Approved	Small molecular drug	[2]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[4]
Ofloxacin	DM0VQN3	Approved	Small molecular drug	[5]
Sulfamethizole	DMGCHDS	Approved	Small molecular drug	[6]
Sulfamethoxazole	DMB08GE	Approved	Small molecular drug	[7]
Trimethoprim	DMM7CHK	Approved	Small molecular drug	[8]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
GSK3902986A	DM4F3MN	Phase 2	Vaccine	[9]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 11 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BPI	TTXCSDR	Strong	Altered Expression	[10]
CAMP	TTULOB6	Strong	Altered Expression	[11]
CASP4	TT6KIOT	Strong	Biomarker	[12]
CD248	TTYJWT7	Strong	Biomarker	[13]
CTSA	TT5NILS	Strong	Genetic Variation	[14]
DHFR	TTYZVDJ	Strong	Genetic Variation	[15]
GLMN	TT2UV5C	Strong	Biomarker	[16]
GPR182	TTT23CG	Strong	Biomarker	[17]
LYZ	TTAOZBW	Strong	Biomarker	[18]
NOD1	TTYSRXM	Strong	Biomarker	[19]
USP14	TTVSYP9	Strong	Genetic Variation	[20]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC9A6	DTN0JXW	Strong	Biomarker	[21]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SULT1A3	DEP7E8X	Strong	Genetic Variation	[10]

This Disease Is Related to 27 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTR2	OT3C8U5T	Strong	Biomarker	[22]
ASZ1	OTLM93UO	Strong	Genetic Variation	[23]
BCKDHA	OT0LHOZB	Strong	Genetic Variation	[16]
CALCOCO2	OTRGX0OV	Strong	Biomarker	[24]
CD48	OT83ZNPP	Strong	Biomarker	[25]
DEFA5	OT95CBQ9	Strong	Biomarker	[26]
EMP1	OTSZHUHQ	Strong	Biomarker	[27]
FLOT2	OTZ0QR5L	Strong	Biomarker	[28]
FNBP1L	OTH1S2P2	Strong	Biomarker	[29]
GBP1	OTUM7RPJ	Strong	Biomarker	[30]
HSD17B6	OTSB55D2	Strong	Biomarker	[31]
MAD2L2	OT24ZO59	Strong	Biomarker	[32]
MRO	OT5U38CP	Strong	Biomarker	[33]
MS4A2	OTMCAS2D	Strong	Biomarker	[34]
MYO9B	OTQ94R5K	Strong	Altered Expression	[35]
NLRC4	OTAIA3NA	Strong	Biomarker	[36]
PHF11	OT5F6LUP	Strong	Biomarker	[34]
QTRT1	OTC33MCV	Strong	Biomarker	[20]
SETD1A	OTVVWRIC	Strong	Biomarker	[37]
SFTPA1	OT87XL1U	Strong	Genetic Variation	[38]
ST8SIA2	OTRBBBD8	Strong	Biomarker	[39]
STX1A	OTSBUZB4	Strong	Biomarker	[40]
STX2	OTO2IDDR	Strong	Biomarker	[40]
SULT1A4	OTHJ8WWV	Strong	Genetic Variation	[10]
SUMF2	OT37I8JL	Strong	Biomarker	[27]
SUMO2	OT1Y5IKN	Strong	Biomarker	[41]
SUMO3	OTTUJQJ1	Strong	Biomarker	[41]

References

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• [8] Trimethoprim FDA Label
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• [34] Alteration in apyrase enzyme attenuated virulence of Shigella flexneri.Microb Pathog. 2016 Feb;91:123-8. doi: 10.1016/j.micpath.2015.12.004. Epub 2015 Dec 17.
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• [38] Precise, direct, and rapid detection of Shigella Spa gene by a novel unmodified AuNPs-based optical genosensing system.J Microbiol Methods. 2019 Jul;162:42-49. doi: 10.1016/j.mimet.2019.05.007. Epub 2019 May 15.
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