Details of Disease

General Information of Disease (ID: DISJF20Z)

Disease Name Glomerulosclerosis
Synonyms glomerular sclerosis
Definition A hardening of the kidney glomerulus caused by scarring of the blood vessels.
Disease Hierarchy
DISQAMHM: Glomerular disorder
DISJF20Z: Glomerulosclerosis
Disease Identifiers
MONDO ID
MONDO_0000490
UMLS CUI
C0178664
MedGen ID
61248
HPO ID
HP:0000096
SNOMED CT ID
197661001

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 19 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
APOL1 TTDB8PW Limited Genetic Variation [1]
RAC1 TT2M9CG moderate Biomarker [2]
REN TTB2MXP moderate Genetic Variation [3]
SERPINE1 TTTO43N moderate Therapeutic [4]
TRPC6 TTRBT3W moderate Altered Expression [5]
AGTR1 TT8DBY3 Strong Altered Expression [6]
AGTR2 TTQVOEI Strong Biomarker [7]
ANGPTL3 TT59GO7 Strong Biomarker [8]
APOA2 TTGQA9W Strong Biomarker [9]
APOE TTKS9CB Strong Biomarker [10]
CRY1 TT5MLZR Strong Altered Expression [11]
LCAT TTGZ91P Strong Biomarker [12]
LOXL2 TTFSUHX Strong Biomarker [13]
MMP1 TTMX39J Strong Biomarker [14]
NAGLU TTDM6HZ Strong Biomarker [15]
RGS2 TTKB7T3 Strong SusceptibilityMutation [16]
SPP1 TT8ME6I Strong Biomarker [17]
TXNRD3 TTDYFVB Strong Biomarker [18]
SLC5A2 TTF8JAT Definitive Biomarker [19]
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⏷ Show the Full List of 19 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC11 DTWN7FC Strong Biomarker [20]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MAT2B DEKF1OH Strong Biomarker [18]
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This Disease Is Related to 30 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
NPHS1 OT21JD3P Limited Biomarker [21]
RAPGEF2 OTZWX2AA Limited Genetic Variation [22]
DROSHA OTCE68KZ Disputed Genetic Variation [23]
SIX2 OTYOVGSC Disputed Genetic Variation [23]
ACTN4 OTCNZAJ5 moderate Genetic Variation [24]
MMRN1 OT7ZNYHT moderate Altered Expression [25]
ACE OTDF1964 Strong Biomarker [26]
APOC1 OTA58CED Strong Altered Expression [27]
ATL1 OTR2788Y Strong Biomarker [28]
CCNG2 OTII38K2 Strong Biomarker [29]
CLCN5 OT9YXZSO Strong Genetic Variation [30]
COL3A1 OTT1EMLM Strong Biomarker [31]
COL4A5 OTHG60RE Strong Genetic Variation [32]
COPB2 OT82JIGC Strong Biomarker [33]
DLX5 OTEEFBEU Strong Biomarker [34]
LMX1B OTM8145D Strong Biomarker [35]
MCM3 OTOOHQPM Strong Biomarker [33]
MYOC OT6DAHNF Strong Altered Expression [36]
NBAS OTW9IBRI Strong Biomarker [15]
NPHS2 OTLCNUII Strong Biomarker [37]
PLEKHA7 OTNUMAZ0 Strong Biomarker [38]
RAP1B OTHEIIMM Strong Posttranslational Modification [39]
RNLS OTVP2WJM Strong Biomarker [40]
SALL1 OTYYZGLH Strong Altered Expression [41]
SCARB2 OTN929M8 Strong Biomarker [42]
SCN7A OTK05PXY Strong Biomarker [15]
CD2AP OTC76KQM Definitive Biomarker [43]
EDA OTAKS5WS Definitive Biomarker [44]
MPV17 OT579DMU Definitive Biomarker [45]
NOX5 OTHTH59G Definitive Altered Expression [46]
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⏷ Show the Full List of 30 DOT(s)

References

1 The Impact of APOL1 on Chronic Kidney Disease and Hypertension.Adv Chronic Kidney Dis. 2019 Mar;26(2):131-136. doi: 10.1053/j.ackd.2019.01.003.
2 Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation.Kidney Blood Press Res. 2019;44(4):513-532. doi: 10.1159/000500457. Epub 2019 Jul 2.
3 Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.Diabetes. 2018 Oct;67(10):2096-2106. doi: 10.2337/db17-1323. Epub 2018 Jul 31.
4 Effects of combination PPAR agonist and angiotensin receptor blocker on glomerulosclerosis.Lab Invest. 2016 Jun;96(6):602-9. doi: 10.1038/labinvest.2016.42. Epub 2016 Mar 21.
5 ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.Ren Fail. 2018 Nov;40(1):266-272. doi: 10.1080/0886022X.2018.1456459.
6 Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats.J Am Soc Nephrol. 2004 Jun;15(6):1475-87. doi: 10.1097/01.asn.0000127988.42710.a7.
7 Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.Am J Physiol Renal Physiol. 2010 Mar;298(3):F683-91. doi: 10.1152/ajprenal.00503.2009. Epub 2009 Dec 30.
8 Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss.BMC Nephrol. 2019 May 24;20(1):185. doi: 10.1186/s12882-019-1383-1.
9 Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions.Aging Cell. 2019 Apr;18(2):e12850. doi: 10.1111/acel.12850. Epub 2019 Feb 22.
10 All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats.Vascul Pharmacol. 2011 Nov-Dec;55(5-6):169-77. doi: 10.1016/j.vph.2011.08.223. Epub 2011 Sep 2.
11 Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-B pathway by binding to CRY1.Mol Med. 2018 Sep 18;24(1):49. doi: 10.1186/s10020-018-0045-2.
12 Hypocomplementemic type II membranoproliferative glomerulonephritis in a male patient with familial lecithin-cholesterol acyltransferase deficiency due to two different allelic mutations.Nephron. 2001 Jul;88(3):268-72. doi: 10.1159/000046001.
13 Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy.Sci Rep. 2018 Jun 21;8(1):9423. doi: 10.1038/s41598-018-27462-6.
14 NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats.Antioxid Redox Signal. 2010 Oct 1;13(7):975-86. doi: 10.1089/ars.2010.3091.
15 Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats.Biomed Pharmacother. 2019 Jan;109:910-920. doi: 10.1016/j.biopha.2018.10.100. Epub 2018 Nov 5.
16 Impaired response of regulator of Gq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats.Hypertens Res. 2016 Apr;39(4):210-6. doi: 10.1038/hr.2015.132. Epub 2015 Nov 26.
17 Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats.Kidney Int. 2003 May;63(5):1791-800. doi: 10.1046/j.1523-1755.2003.00929.x.
18 Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions.Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14448-53. doi: 10.1073/pnas.0703577104. Epub 2007 Aug 28.
19 SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?.Curr Med Chem. 2019;26(29):5564-5578. doi: 10.2174/0929867325666180524114033.
20 Predictive significance of kidney myeloid-related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases.PLoS One. 2014 Feb 18;9(2):e88942. doi: 10.1371/journal.pone.0088942. eCollection 2014.
21 Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations.Clin J Am Soc Nephrol. 2009 Jun;4(6):1065-72. doi: 10.2215/CJN.03910808. Epub 2009 Apr 30.
22 Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2.Kidney Int. 2019 Sep;96(3):642-655. doi: 10.1016/j.kint.2019.03.016. Epub 2019 Mar 28.
23 Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.Int J Cancer. 2019 Mar 15;144(6):1391-1400. doi: 10.1002/ijc.31952. Epub 2018 Dec 3.
24 Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease.Kidney Int. 2008 Mar;73(6):741-50. doi: 10.1038/sj.ki.5002751. Epub 2008 Jan 9.
25 Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway.J Cell Physiol. 2018 Mar;233(3):2225-2237. doi: 10.1002/jcp.26092. Epub 2017 Sep 13.
26 ASK1 contributes to fibrosis and dysfunction in models of kidney disease.J Clin Invest. 2018 Oct 1;128(10):4485-4500. doi: 10.1172/JCI99768. Epub 2018 Jul 19.
27 Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.J Pathol. 2017 Apr;241(5):589-599. doi: 10.1002/path.4859. Epub 2017 Feb 2.
28 Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis.Nephron Clin Pract. 2012;120(1):c1-7. doi: 10.1159/000334184. Epub 2011 Nov 23.
29 Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling.Biomed Res Int. 2018 Oct 21;2018:6938482. doi: 10.1155/2018/6938482. eCollection 2018.
30 A novel CLCN5 mutation in a boy with asymptomatic proteinuria and focal global glomerulosclerosis.Clin Nephrol. 2013 Nov;80(5):377-84. doi: 10.5414/CN107429.
31 Alterations in chromatin are associated with increases in collagen III expression in aging nephropathy.Am J Physiol Renal Physiol. 2011 Feb;300(2):F531-9. doi: 10.1152/ajprenal.00237.2010. Epub 2010 Jul 7.
32 Alport syndrome: from bedside to genome to bedside.Am J Kidney Dis. 1993 Nov;22(5):627-40. doi: 10.1016/s0272-6386(12)80424-0.
33 SND p102 promotes extracellular matrix accumulation and cell proliferation in rat glomerular mesangial cells via the AT1R/ERK/Smad3 pathway.Acta Pharmacol Sin. 2018 Sep;39(9):1513-1521. doi: 10.1038/aps.2017.184. Epub 2018 May 10.
34 DLX5 gene regulates the Notch signaling pathway to promote glomerulosclerosis and interstitial fibrosis in uremic rats.J Cell Physiol. 2019 Dec;234(12):21825-21837. doi: 10.1002/jcp.28032. Epub 2019 Jul 11.
35 Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy.Transgenic Res. 2007 Dec;16(6):723-9. doi: 10.1007/s11248-007-9118-7. Epub 2007 Jul 27.
36 Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis.Kidney Int. 2005 Jan;67(1):140-51. doi: 10.1111/j.1523-1755.2005.00064.x.
37 Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting -catenin activity.J Cell Mol Med. 2019 Jun;23(6):4443-4453. doi: 10.1111/jcmm.14340. Epub 2019 Apr 16.
38 Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12817-22. doi: 10.1073/pnas.1410745111. Epub 2014 Aug 18.
39 Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.J Clin Invest. 2014 Apr;124(4):1757-69. doi: 10.1172/JCI67846. Epub 2014 Mar 18.
40 Lisinopril protects against the adriamycin nephropathy and reverses the renalase reduction: potential role of renalase in adriamycin nephropathy.Kidney Blood Press Res. 2013;37(4-5):295-304. doi: 10.1159/000350157. Epub 2013 Sep 5.
41 Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis.Lab Invest. 2017 Nov;97(11):1306-1320. doi: 10.1038/labinvest.2017.69. Epub 2017 Jul 31.
42 Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis. Am J Hum Genet. 2008 Mar;82(3):673-84. doi: 10.1016/j.ajhg.2007.12.019. Epub 2008 Feb 28.
43 Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis.Sci Rep. 2017 Sep 6;7(1):10731. doi: 10.1038/s41598-017-10512-w.
44 Alternatively spliced isoforms of fibronectin in immune-mediated glomerulosclerosis: the role of TGFbeta and IL-4.J Pathol. 2004 Nov;204(3):248-57. doi: 10.1002/path.1653.
45 SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mammalian kidney disease gene Mpv17 and is required for ethanol metabolism and tolerance during heat shock.Eukaryot Cell. 2004 Jun;3(3):620-31. doi: 10.1128/EC.3.3.620-631.2004.
46 Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse.Diabetologia. 2019 Sep;62(9):1712-1726. doi: 10.1007/s00125-019-4924-z. Epub 2019 Jun 20.