Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0GOUD)

Drug Name

Urokinase Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Myocardial infarction	BA41-BA43	Approved	[1]
Pulmonary embolism	BB00	Approved	[2]

Therapeutic Class

Thrombolytic Agents

Cross-matching ID

PubChem CID: 33309
TTD Drug ID: DM0GOUD

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pro-urokinase	DMGKT2L	Thrombin deficiency	3B14.Z	Approved	[5]
PAI-1	DMY2AEF	N. A.	N. A.	Phase 4	[6]
Amediplase	DM4FPM3	Myocardial infarction	BA41-BA43	Phase 3	[1]
Upamostat	DMFZULI	Breast cancer	2C60-2C65	Phase 2	[7]
Saruplase	DM1M0PR	Thrombosis	DB61-GB90	Phase 2	[8]
HTU-PA	DMNHE43	Cerebrovascular ischaemia	8B1Z	Phase 1/2	[9]
PMID18163548C4	DMHPME3	Myocardial ischemia	BA6Z	Clinical trial	[10]
UK-356202	DMSRK2A	Myocardial hypertrophy	BC45	Clinical trial	[11]
PAI-2	DMRSMW8	N. A.	N. A.	Discontinued in Phase 2	[12]
WX-UK1	DM8Q2ZR	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1/2	[13]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[16]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[21]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
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Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
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Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[29]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
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Drug(s) Affected By Tyrosine-protein kinase CSK (CSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Urokinase-type plasminogen activator (PLAU)	TTGY7WI	UROK_HUMAN	Modulator	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Drug Response	[4]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Drug Response	[4]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Drug Response	[4]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Drug Response	[4]

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