Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0MUKQ)

• Drug Name: Guanosine-5'-Diphosphate Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 135398619
  ChEBI ID: CHEBI:17552
  CAS Number: CAS 146-91-8
  TTD Drug ID: DM0MUKQ

Molecule-Related Drug Atlas

Drug(s) Targeting Tissue transglutaminase (TG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZED1227	DMDXEN5	Coeliac disease	DA95	Phase 2	[6]
PMID26560530-Compound-13	DMKF26Z	N. A.	N. A.	Patented	[7]
PMID26560530-Compound-54	DM2X4R0	N. A.	N. A.	Patented	[7]
Triazole derivative 1	DM9QB2S	N. A.	N. A.	Patented	[7]
Acyl piperidine derivative 3	DMIDUB4	N. A.	N. A.	Patented	[7]
PMID26560530-Compound-14	DM52MIK	N. A.	N. A.	Patented	[7]
PMID26560530-Compound-1	DMSI7F2	N. A.	N. A.	Patented	[7]
PMID26560530-Compound-3	DM92OT0	N. A.	N. A.	Patented	[7]
PMID26560530-Compound-11	DMZ5UST	N. A.	N. A.	Patented	[7]
Chloroacetyl ester derivative 1	DMW4J0P	N. A.	N. A.	Patented	[7]

Drug(s) Targeting Candida Elongation factor 2 (Candi EFT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine-5-Diphosphoribose	DM96LBV	Discovery agent	N.A.	Investigative	[2]
Diphthamide	DMRWD9M	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Ras-related protein Rab-9A (RAB9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[2]

Drug(s) Targeting Bacterial Celldivision protein FtsZ (Bact ftsZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TXA709	DMZIK8R	MRSA infection	1D01.0Y	Phase 1	[9]
Phosphomethylphosphonic Acid Guanylate Ester	DM4IRU5	Discovery agent	N.A.	Investigative	[2]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ge2270a	DMJK7V0	Bacterial infection	1A00-1C4Z	Phase 1	[2]
Amythiamicin	DM7SHQ1	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Streptococcus Elongation factor G (Stre-coc fusA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fusidic Acid	DMWVCF3	Acne vulgaris	ED80	Approved	[11]

Drug(s) Targeting Bacterial GTP-binding protein YihA (Bact engB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Plasmodium Adenylosuccinate synthetase (Malaria Adss)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[2]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[2]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[2]
6-Cl-IMP	DMNTDFV	Discovery agent	N.A.	Investigative	[12]
(Carboxyhydroxyamino)Ethanoic Acid	DMZB0C3	Discovery agent	N.A.	Investigative	[2]
(C8-R)-Hydantocidin 5'-Phosphate	DM5WH6R	Discovery agent	N.A.	Investigative	[2]
(C8-S)-Hydantocidin 5'-Phosphate	DMMH179	Discovery agent	N.A.	Investigative	[2]
6-O-Phosphoryl Inosine Monophosphate	DM6YHBR	Discovery agent	N.A.	Investigative	[2]
Hydantocidin-5'-Monophosphate	DMOTXP1	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By GDP-mannose 4,6 dehydratase (GMDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[38]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Celldivision protein FtsZ (Bact ftsZ)	TT4W1VJ	FTSZ_WOLSP	Inhibitor	[2]
Bacterial GTP-binding protein YihA (Bact engB)	TTO3MV6	ENGB_ECOLI	Inhibitor	[2]
Candida Elongation factor 2 (Candi EFT2)	TTCNGJ5	EF2_CANAL	Inhibitor	[2]
Plasmodium Adenylosuccinate synthetase (Malaria Adss)	TTYQ4AE	PURA_PLAFA	Inhibitor	[2]
Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1)	TTG45NU	EF1A_PLAFK	Inhibitor	[2]
Ras-related protein Rab-9A (RAB9A)	TT958S6	RAB9A_HUMAN	Inhibitor	[2]
Streptococcus Elongation factor G (Stre-coc fusA)	TT6HP1T	EFG_STRZJ	Inhibitor	[2]
Tissue transglutaminase (TG2)	TT2F4OL	TGM2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-(1,6)-fucosyltransferase (FUT8)	OTJJCVG1	FUT8_HUMAN	Gene/Protein Processing	[3]
GDP-mannose 4,6 dehydratase (GMDS)	OTWV79YD	GMDS_HUMAN	Protein Interaction/Cellular Processes	[4]
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Protein Interaction/Cellular Processes	[5]

References

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