Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1F42Z)

Drug Name

Oxatomide Drug Info

Synonyms

Celtect; Oxatimide; Oxatomida; Oxatomidum; Oxetal; Tinset; CBMicro_024634; KW 4354; O 9387; R 35443; R35443; Celtect (TN); KW-4354; McN-JR 35443; Oxatomida [INN-Spanish]; Oxatomide (tinset); Oxatomidum [INN-Latin]; R 35,443; R-35443; Oxatomide (JAN/USAN/INN); Oxatomide [USAN:BAN:INN:JAN]; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone; 1-[3-(4-Benzhydryl-piperazin-1-yl)-propyl]-1,3-dihydro-benzoimidazol-2-one; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-2-benzimidazolinone; 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one

Indication

Disease Entry	ICD 11	Status	REF
Hay fever	CA08.00	Approved	[1]

Therapeutic Class

Antiallergic Agents

Cross-matching ID

PubChem CID: 4615
ChEBI ID: CHEBI:31943
CAS Number: CAS 60607-34-3
TTD Drug ID: DM1F42Z
INTEDE Drug ID: DR1213

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Histamine H1 receptor (H1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[3]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[4]
Azelastine	DMXTMBJ	Allergic conjunctivitis	9A60.02	Approved	[1]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[5]
Cinnarizine	DM7U5QJ	Meniere disease	AB31.0	Approved	[6]
Diphenhydramine	DMKQTBA	Hyperemesis gravidarum		Approved	[1]
Doxepin	DMPI98T	Anxiety		Approved	[7]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[1]
Epinastine	DMX0K3Q	Allergic conjunctivitis	9A60.02	Approved	[8]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[9]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[18]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[22]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[23]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[24]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[25]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[28]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[31]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[33]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[34]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[35]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[36]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[2]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Gene/Protein Processing	[2]

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