Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2WE5K)

Drug Name

Ceruletide Drug Info

Synonyms

Caerulein; Cerulein; Ceruletida; Ceruletidum; Ceruletida [INN-Spanish]; Ceruletidum [INN-Latin]; Ceruletide (USAN/INN); Ceruletide [USAN:INN:BAN]; 5-Oxo-L-prolyl-L-glutaminyl-L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide; 5-Oxo-L-prolyl-L-glutaminyl-L-aspartyl-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide 4-(hydrogen sulfate) (ester); 5-oxo-L-prolyl-L-glutaminyl-L-a-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-a-aspartyl-L-phenylalaninamide

Indication

Disease Entry	ICD 11	Status	REF
Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]

Therapeutic Class

Diagnostic Agents

Cross-matching ID

PubChem CID: 16129675
ChEBI ID: CHEBI:59219
CAS Number: CAS 17650-98-5
TTD Drug ID: DM2WE5K

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Gastrin/cholecystokinin type B receptor (CCKBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentagastrin	DMRCLZB	Diagnostic imaging	N.A.	Approved	[5]
GASTRAZOLE	DMO3ITF	Duodenal ulcer	DA63	Phase 3	[6]
Dexloxiglumide	DM52HUD	Pancreatic malfunction	DC30-DC3Z	Phase 2	[7]
Spiroglumide	DM7NJWY	Stomach disease	DA43-DA4Y	Phase 2	[8]
TT-223	DMCDMFP	Type-1 diabetes	5A10	Phase 2	[9]
Z 360	DM2M80G	Discovery agent	N.A.	Phase 2	[10]
S-0509	DM4KWEF	Ulcerative colitis	DD71	Phase 2	[11]
YF-476	DM54MAJ	Stomach ulcer	DA60.Z	Phase 2	[12]
Itriglumide	DM5UFRO	Anxiety disorder	6B00-6B0Z	Phase 2	[13]
Demogastrin	DMTULGS	Thyroid cancer	2D10	Phase 1	[14]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[17]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[24]
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Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[25]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[26]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[28]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[32]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
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Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[34]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[34]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[36]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[39]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[40]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[41]
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Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[51]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastrin/cholecystokinin type B receptor (CCKBR)	TTVFO0U	GASR_HUMAN	Agonist	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[4]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Gene/Protein Processing	[4]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Gene/Protein Processing	[4]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Gene/Protein Processing	[4]

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References

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