Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GQD7)

Drug Name
Metoprine Drug Info
Synonyms
METOPRINE; Methodichlorophen; DDMP; 7761-45-7; Metoprine [USAN]; BW-197U; TCMDC-123931; NSC-19494; SK 5265; 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE; U 197; NSC7364; U-197; UNII-2L9RKX796Q; Metoprine (USAN); BW 50-197; METOPRINE, METHODICHLOROPHEN; 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; NSC 7364; 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-; NSC 19494; BW50197; BRN 0223622; 5-(3,4-Dichlorphenyl)-6-methyl-2,4-pyrimidindiamin; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; MLS002701892; DDMP; BW 197 U; BW 1970; BW 197U; BW 50197; BW 50,197; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methyl pyrimidine; Chloroaniline 1
Indication
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Phase 2 [1]
Cross-matching ID
PubChem CID
24466
CAS Number
CAS 7761-45-7
TTD Drug ID
DM5GQD7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine N-methyltransferase (HNMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [2]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [6]
(L-)-S-adenosyl-L-homocysteine DMDUN83 Discovery agent N.A. Investigative [7]
4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE DM68S9F Discovery agent N.A. Investigative [2]
Drug(s) Targeting Polypeptide deformylase (PDF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Proguanil DMBL79I Malaria 1F40-1F45 Approved [8]
Meprobamate DMHM93Y Anxiety Approved [9]
Pralatrexate DMAO80I Breast cancer 2C60-2C65 Approved [10]
Ustekinumab DMHTYK3 Plaque psoriasis EA90.0 Approved [11]
Trimetrexate DMDEA85 Toxoplasmosis 1F57 Approved [12]
MCB-3837 DM0R4Z5 Malaria 1F40-1F45 Approved [9]
Chlorproguanil DM1IFGT Malaria 1F40-1F45 Approved [9]
LY333531 DMGMC8H Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
Aminopterin DMQ9RBV leukaemia 2A60-2B33 Withdrawn from market [14]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [7]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [17]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [18]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [19]
Paclitaxel DMLB81S Breast carcinoma Approved [20]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
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Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [31]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [32]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
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Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Panobinostat DM58WKG Chronic graft versus host disease Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [38]
Bortezomib DMNO38U Leukemia Approved [5]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [5]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [40]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine N-methyltransferase (HNMT) TT2B6EV HNMT_HUMAN Inhibitor [2]
Polypeptide deformylase (PDF) TT9SL3Q DEFM_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) OTU0FC24 COX41_HUMAN Gene/Protein Processing [5]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Gene/Protein Processing [5]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Gene/Protein Processing [5]

References

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