Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7EVLC)

Drug Name
Bendroflumethiazide Drug Info
Synonyms
Aprinox; BHFT; Bendrofluazide; Bendroflumethazide; Bendroflumethiazidum; Bendroflumetiazida; Bendroflumetiazide; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bristuric; Bristuron; Centyl; Corzide; Flumersil; Flumesil; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturine; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rauzide; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea; Bendroflumethiazide [USP]; Bendroflumetiazide [DCIT]; Rautrax N; Relan beta; BL H368; FT 8; FT 81; Be 724-A; Bendroflumethiazidum [INN-Latin]; Bendroflumetiazida [INN-Spanish]; Benzy-rodiuran; NATURETIN-10; NATURETIN-5; Naturetin (TN); Neo-naclex; Neo-rontyl; Naturetin-2.5; Bendroflumethiazide (JAN/USP/INN); (+-)-3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
Indication
Disease Entry ICD 11 Status REF
High blood pressure BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
2315
ChEBI ID
CHEBI:3013
CAS Number
CAS 73-48-3
TTD Drug ID
DM7EVLC
VARIDT Drug ID
DR01028

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Solute carrier family 12 member 3 (SLC12A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metolazone DMB39LO Edema MG29 Approved [6]
Polythiazide DMCH80F Edema MG29 Approved [6]
Drug(s) Targeting Solute carrier family 12 member 1 (SLC12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [7]
Potassium Chloride DMMTAJC Hypokalemia 5C77 Approved [8]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [9]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [10]
Ethacrynic acid DM60QMR Edema MG29 Approved [11]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [12]
Trichlormethiazide DMHAQCO Hypertension BA00-BA04 Approved [13]
Hydroflumethiazide DMVPUQI Congestive heart failure BD10 Approved [2]
Methyclothiazide DMN7SDE Edema MG29 Approved [2]
Chlorthalidone DM4DMBT Edema MG29 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [15]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [19]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [20]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [21]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [23]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [24]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [25]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [26]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [27]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [29]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [30]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [31]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [32]
Epinephrine DM3KJBC Acute asthma CA23 Approved [33]
Chlorthalidone DM4DMBT Edema MG29 Approved [34]
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Drug(s) Affected By Apolipoprotein B-100 (APOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [40]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [35]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [41]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Solute carrier family 12 member 1 (SLC12A1) TTS087L S12A1_HUMAN Blocker [2]
Solute carrier family 12 member 3 (SLC12A3) TTP362L S12A3_HUMAN Blocker [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Gene/Protein Processing [3]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [4]
Thiopurine S-methyltransferase (TPMT) OTFOX70W TPMT_HUMAN Gene/Protein Processing [5]

References

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24 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
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