Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB0OZ3)

Drug Name
PF-429242 Drug Info
Synonyms
947303-87-9; PF-429242; (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide; UNII-49WB3OA7VN; 49WB3OA7VN; PF 429242; PF429242; CHEMBL233611; J-502224; C25H35N3O2; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide; (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benz amide; (-)-PF-429242; SCHEMBL2742702; CTK8B5018; DTXSID00635376; EX-A1409; ANW-47048; ZINC28823615; BDBM50216181; AKOS015998619; RL05965; Benzamide, 4-((diethylamino)methyl)-N-(2-(
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
23661637
CAS Number
CAS 947303-87-9
TTD Drug ID
DMB0OZ3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [5]
Fructose DM43AN2 Vomiting MD90 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [11]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [12]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [13]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
Fluoxetine DM3PD2C Bipolar depression Approved [17]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [20]
Selenium DM25CGV N. A. N. A. Approved [21]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [23]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [30]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [5]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Fluoxetine DM3PD2C Bipolar depression Approved [5]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [6]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [34]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Paclitaxel DMLB81S Breast carcinoma Approved [36]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [14]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [7]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endopeptidase S1P (MBTPS1) TTNSM2I MBTP1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Gene/Protein Processing [2]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [3]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Gene/Protein Processing [2]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Gene/Protein Processing [2]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Gene/Protein Processing [2]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Protein Interaction/Cellular Processes [3]

References

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21 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
22 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
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26 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
27 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
28 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
29 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
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