Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBI4JG)

Drug Name
Isosorbide Dinitrate Drug Info
Synonyms
Angidil; Astridine; BiDil; Cardis; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Coronex; Corosorbide; Corovliss; Difutrat; Dignionitrat; Dilatrate; Diniket; Dinitroisosorbide; Dinitrosorbide; Disorlon; Emoper; EureCor; Flindix; Frandol; Harrical; ISD; ISDN; IsoBid; Isochron; Isodinit; Isoket; Isorbid; Isordil; Isostat; Isotrate; Korodil; Langoran; Laserdil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rigedal; Sorbangil; Sorbide; Sorbidilat; Sorbidinitrate; Sorbidnitrate; Sorbislo; Sorbitrate; Sorbonit; Sorquad; Sorquat; Tinidil; Titradose; Vascardin; Vasodilat; Vasorbate; Xanyl; Cedocard Retard; Dilatrate SR; Dinitrato de isosorbida; Iso Bid; Isomak R; Isordil Tembids; Isosorbide dinitrato; Isosorbide dinitrato [DCIT]; Isosorbidi dinitras; Isosorbidi nitras; Rifloc Retard; Sorbide nitrate; Sorbidi nitras; Cardio 10; Cardonit 40; IBD 20; Isoket Retard 120; Isoket Retard120; Isoket retard 40; TYB 3215; Cedocard (TN); D-Isosorbide dinitrate; Dilatrate-SR; Dinitrate d'isosorbide; Dinitrate, Isosorbide; Dinitrato de isosorbida [INN-Spanish]; Iso-Bid; Iso-Mack; Iso-Puren; Isoket Retard-120; Isordil (TN); Isosorbidi dinitras [INN-Latin]; SDM No. 40; SDM No. 50; SST-101; Sorate-10; Sorate-5; Sorbide, dinitrate; Sorbitrate (TN); D-Isosorbide dinitrate-Lactose mixture; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-sr (TN); Dinitrate d'isosorbide [INN-French]; Isosorbide 2,5-dinitrate; Sorbide T.D.; Glucitol, 1,4:3; Isosorbide dinitrate (JP15/USP/INN); Isosorbide dinitrate [USAN:INN:BAN:JAN]; Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate [UN2907] [Flammable solid]; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate; [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate; 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
Indication
Disease Entry ICD 11 Status REF
Anal fissure DB50.0 Approved [1]
Angina pectoris BA40 Approved [1]
Chronic heart failure BD1Z Approved [2]
Therapeutic Class
Vasodilator Agents
Cross-matching ID
PubChem CID
6883
ChEBI ID
CHEBI:6061
CAS Number
CAS 87-33-2
TTD Drug ID
DMBI4JG
INTEDE Drug ID
DR0888
ACDINA Drug ID
D00333

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Guanylate cyclase (GC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [3]
Methylene blue DMJAPE7 Acquired methemoglobinemia 3A93 Approved [8]
Isosorbide Mononitrate DMYLMU0 Angina pectoris BA40 Approved [3]
Erythrityl Tetranitrate DMFGQ2S Angina pectoris BA40 Approved [3]
Pirsidomine DMHI6GE Angina pectoris BA40 Phase 2 [9]
IW-1701 DM457XO Sickle-cell disorder 3A51 Phase 2 [10]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [11]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [13]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [14]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Glutathione S-transferase alpha-1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [23]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [24]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [25]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [26]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [27]
Ethacrynic acid DM60QMR Edema MG29 Approved [28]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [29]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [30]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [6]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [31]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Ethacrynic acid DM60QMR Edema MG29 Approved [35]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [36]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [37]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [38]
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Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [47]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [48]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylate cyclase (GC) TT6HPVC NOUNIPROTAC Stimulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Glutathione S-transferase alpha-1 (GSTA1) DE4ZHS1 GSTA1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [6]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Drug Response [7]

References

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2 Isosorbide dinitrate FDA Label
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