Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD3CUJ)

• Drug Name: T-5224 Drug Info
• Synonyms: AKOS003047196; T5224

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 23626877
  ChEBI ID: CHEMBL3222137
  TTD Drug ID: DMD3CUJ

Molecule-Related Drug Atlas

Drug(s) Targeting Transcription factor AP-1 (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TWS-119	DMS29M4	Discovery agent	N.A.	Investigative	[4]
PNRI-299	DMDBZGP	Discovery agent	N.A.	Investigative	[5]
TAM-67	DM26SE7	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[7]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[8]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[9]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[13]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[14]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[19]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[20]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[21]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[22]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[21]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[26]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[33]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Bortezomib	DMNO38U	Leukemia		Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[40]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[41]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transcription factor AP-1 (JUN)	TTN3GBV	JUN_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Interferon regulatory factor 4 (IRF4)	OT1DHQ1P	IRF4_HUMAN	Gene/Protein Processing	[3]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[3]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[3]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Gene/Protein Processing	[3]

References

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