Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD3CUJ)

Drug Name
T-5224 Drug Info
Synonyms AKOS003047196; T5224
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
23626877
TTD Drug ID
DMD3CUJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Transcription factor AP-1 (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TWS-119 DMS29M4 Discovery agent N.A. Investigative [4]
PNRI-299 DMDBZGP Discovery agent N.A. Investigative [5]
TAM-67 DM26SE7 Discovery agent N.A. Investigative [6]
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [9]
Gefitinib DM15F0X Colon adenocarcinoma Approved [10]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [11]
Selenium DM25CGV N. A. N. A. Approved [12]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [13]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [17]
Gefitinib DM15F0X Colon adenocarcinoma Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [20]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [21]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [22]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [21]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [23]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [33]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [34]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [38]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [39]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [43]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [44]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [48]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [49]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 4 (IRF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [56]
Bortezomib DMNO38U Leukemia Approved [3]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [58]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [59]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [60]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transcription factor AP-1 (JUN) TTN3GBV JUN_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Protein Interaction/Cellular Processes [3]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Gene/Protein Processing [3]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [3]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [3]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Gene/Protein Processing [3]

References

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