Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME9VTX)

Drug Name
ROCAGLAMIDE Drug Info
Synonyms
Rocaglamide; 84573-16-0; MLS002701812; CHEMBL438139; CHEBI:66309; NSC326408; NSC 326408; 1H-Cyclopenta(b)benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-; (1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-1,8b-bis(oxidanyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
331783
ChEBI ID
CHEBI:66309
CAS Number
CAS 84573-16-0
TTD Drug ID
DME9VTX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [3]
Triptolide DMCMDVR Autoimmune diabetes 5A10 Phase 3 [4]
Laquinimod DM3IWS8 Lupus 4A40 Phase 3 [5]
Edasalonexent DMYVBF6 Duchenne dystrophy 8C70 Phase 3 [6]
MD1003 DMVZ57G Multiple sclerosis 8A40 Phase 3 [6]
Vadimezan DMK7CYX Solid tumour/cancer 2A00-2F9Z Phase 2 [7]
CAT 1004 DMQBP7R Duchenne dystrophy 8C70 Phase 2 [8]
Parthenolide DMCQBFT N. A. N. A. Phase 2 [9]
Recoflavone DMCSR8I Inflammatory bowel disease DD72 Phase 2 [10]
CZEN-002 DMUDMHA Fungal infection 1F29-1F2F Phase 2 [11]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [12]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [13]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [12]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [16]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [19]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [20]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [21]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [24]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [26]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [35]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [36]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [40]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [43]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [66]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [72]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [40]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [45]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [74]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [61]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Meloxicam DM2AR7L Arthritis FA20 Approved [76]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [36]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nuclear factor NF-kappa-B (NFKB) TTSXVID NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [2]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Gene/Protein Processing [2]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Gene/Protein Processing [2]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Gene/Protein Processing [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Gene/Protein Processing [2]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Gene/Protein Processing [2]

References

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39 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
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41 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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71 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
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74 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
75 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
76 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.