Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGS4QH)

Drug Name
Methacholine Chloride Drug Info
Synonyms
Methacholine; methacholine; Acetylmethylcholine; Methacholin; Mecholine; Mecholin; Provocholine; Methacholinum; beta-Methylacetylcholine; 55-92-5; Choline, acetyl-beta-methyl-; Acetyl-beta-methylcholine; BRN 1769932; CHEBI:6804; 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; AMMONIUM, (2-HYDROXYPROPYL)TRIMETHYL-, ACETATE (ESTER); 2-acetyloxypropyl(trimethyl)azanium; C8H18NO2; AC1Q5XYD; AC1L1COQ; Prestwick2_000759; Prestwick0_000759; Prestwick3_000759; Prestwick1_000759; CHEMBL978; 2-(acetyloxy)-n,n,n-trimethylpropan-1-aminium; METHACHOLINE
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Approved [1]
bronchial hyperreactivity CB40 Approved [2]
Cross-matching ID
PubChem CID
6114
ChEBI ID
CHEBI:50142
CAS Number
CAS 62-51-1
TTD Drug ID
DMGS4QH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor M4 (CHRM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [7]
Tropicamide DM1D90W Mydriasis LA11.62 Approved [8]
Diphenidol DMHPWOM Nausea MD90 Approved [9]
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G Discovery agent N.A. Investigative [10]
A-987306 DMU34BK Discovery agent N.A. Investigative [11]
ISOCLOZAPINE DM52CPU Discovery agent N.A. Investigative [12]
FLUMEZAPINE DMW0HOG Discovery agent N.A. Investigative [13]
ISOLOXAPINE DMH1BN4 Discovery agent N.A. Investigative [14]
Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 Discovery agent N.A. Investigative [3]
GNF-PF-5618 DMT8VUS Discovery agent N.A. Investigative [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Muscarinic acetylcholine receptor M2 (CHRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [7]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [16]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [17]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [18]
FP-1097 DMC1F2T Urinary incontinence MF50.2 Phase 2 [19]
PSD-506 DMT0KB1 Overactive bladder GC50.0 Discontinued in Phase 2 [20]
Otenzepad DMRXHAC Heart failure BD10-BD13 Discontinued in Phase 2 [21]
SCH-211803 DM92E0W Parkinson disease 8A00.0 Discontinued in Phase 1 [22]
Alvameline DMLN0Y5 Alzheimer disease 8A20 Terminated [23]
HIMBACINE DMGAKD8 N. A. N. A. Terminated [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [25]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [7]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [26]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [27]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [28]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [16]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [29]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [30]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [31]
Methscopolamine Bromide DMHP8FI Nausea and vomiting MD90 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low affinity immunoglobulin epsilon Fc receptor (FCER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [33]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [38]
Nitrite DMR5XT3 N. A. N. A. Investigative [39]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [45]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [46]
Leflunomide DMR8ONJ Arthritis FA20 Approved [47]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short transient receptor potential channel 3 (TRPC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Paclitaxel DMLB81S Breast carcinoma Approved [51]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [52]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [53]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [54]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [55]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M2 (CHRM2) TTYEG6Q ACM2_HUMAN Inhibitor [3]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Modulator [4]
Muscarinic acetylcholine receptor M4 (CHRM4) TTQ3JTF ACM4_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Gene/Protein Processing [5]
Low affinity immunoglobulin epsilon Fc receptor (FCER2) OTU40XWZ FCER2_HUMAN Gene/Protein Processing [5]
Short transient receptor potential channel 3 (TRPC3) OTNR61OD TRPC3_HUMAN Gene/Protein Processing [6]

References

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