Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH2CKX)

• Drug Name: METHOCTRAMINE Drug Info
• Synonyms: Methoctramine; CHEBI:73339; UNII-NVJ76B897D; CHEMBL27673; NVJ76B897D; n,n'-bis{6-[(2-methoxybenzyl)amino]hexyl}octane-1,8-diamine; N1,N8-bis(6-(2-methoxybenzylamino)hexyl)octane-1,8-diamine; N,N'-bis[6-[(2-Methoxyphenyl)methylamino]hexyl]octane-1,8-diamine; N,N'-Bis(6-((2-methoxyphenyl)methylamino)hexyl)octane-1,8-diamine; N,N'-Bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine; N,N'-Bis(6-(((2-methoxyphenyl)methyl)amino)hexyl)-1,8-octanediamine; Methoctramine free base; NCGC00015626-01; Lopac-M-105

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 107759
  ChEBI ID: CHEBI:73452
  CAS Number: CAS 104807-46-7
  TTD Drug ID: DMH2CKX

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[5]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[6]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[7]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[8]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[9]
AST-004	DM5WMG7	Stroke	8B20	Phase 1	[10]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[2]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[11]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[8]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[8]

Drug(s) Targeting Muscarinic acetylcholine receptor M2 (CHRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[12]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[13]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[14]
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[15]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[16]
FP-1097	DMC1F2T	Urinary incontinence	MF50.2	Phase 2	[17]
PSD-506	DMT0KB1	Overactive bladder	GC50.0	Discontinued in Phase 2	[18]
Otenzepad	DMRXHAC	Heart failure	BD10-BD13	Discontinued in Phase 2	[19]
SCH-211803	DM92E0W	Parkinson disease	8A00.0	Discontinued in Phase 1	[20]
Alvameline	DMLN0Y5	Alzheimer disease	8A20	Terminated	[21]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[2]
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Gene/Protein Processing	[4]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Gene/Protein Processing	[4]

References

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